The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

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Near-Infrared-Absorbing B–N Lewis Pair-Functionalized Anthracenes: Electronic Structure Tuning, Conformational Isomerism, and Applications in Photothermal Cancer Therapy

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(41), P. 18908 - 18917

Published: Oct. 4, 2022

B–N-fused dianthracenylpyrazine derivatives are synthesized to generate new low gap chromophores. Photophysical and electrochemical, crystal packing, theoretical studies have been performed. Two energetically similar conformers identified by density functional theory calculations, showing that the core unit adopts a curved saddle-like shape (x-isomer) or zig-zag conformation (z-isomer). In solid state, z-isomer is prevalent according an X-ray structure of C6F5-substituted derivative (4-Pf), but variable-temperature nuclear magnetic resonance suggest dynamic behavior in solution. B–N fusion results large decrease HOMO–LUMO dramatically lowers LUMO energy compared all-carbon analogues. 4-Pf particular shows significant absorbance at greater than 700 nm while being almost transparent throughout visible region. After encapsulation biodegradable polymer DSPE-mPEG2000, nanoparticles (4-Pf-NPs) exhibit good water solubility, high photostability, excellent photothermal conversion efficiency ∼41.8%. 4-Pf-NPs evaluated both vitro vivo as therapeutic agents. These uncover Lewis pair functionalization PAHs promising strategy toward NIR-absorbing materials for applications.

Language: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: March 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Language: Английский

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Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(30)

Published: May 11, 2022

Nonradiative decay invariably competes with radiative during the deexcitation process of matter. In community luminescence research, nonradiative has been deemed less attractive than decay. However, all things in their being are good for something and so is As molecular motion-facilitated (MMFND) effect inevitable photophysical processes, it provides a new avenue to convert harvested light energy into exploitable forms by harnessing motion. many cases, active motion enables thermal deactivation from excited states. this Minireview, recent advances photothermal photoacoustic systems MMFND character summarized. We believe that presentation rational engineering efficient generation will deepen understanding relationship between navigate people rethink positive aspects establishment light-controllable techniques.

Language: Английский

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Self‐Sacrificially Degradable Pseudo‐Semiconducting Polymer Nanoparticles that Integrate NIR‐II Fluorescence Bioimaging, Photodynamic Immunotherapy, and Photo‐Activated Chemotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(34)

Published: July 12, 2022

Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, clinical application is still hampered by poor biodegradability. Herein, a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT) reported. The PSP can further co-assemble with an amphiphilic polyester pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PEDOX ), which are denoted as NP@PEDOX /PSP. /PSP accumulate at tumor sites generate ROS immunotherapy well near-infrared-II (NIR-II) bioimaging upon irradition 808 nm. could break up PEDOX , resulting rapid release PACT. Finally, both degraded sacrificially intracellular glutathione (GSH), the dissociation of This work highlights degradable PACT therapy.

Language: Английский

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Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(6), P. 3736 - 3747

Published: Feb. 2, 2023

Ferroptosis, a newly discovered form of regulated cell death, is emerging as promising approach to tumor therapy. However, the spatiotemporal control cell-intrinsic Fenton chemistry modulate ferroptosis remains challenging. Here, we report an oxazine-based activatable molecular assembly (PTO-Biotin Nps), which capable triggering lysosomal dysfunction-mediated pathway with excellent resolution via near-infrared (NIR) light evoke ferroptosis. In this system, pH-responsive NIR photothermal oxazine molecule was designed and functionalized tumor-targeting hydrophilic biotin-poly(ethylene glycol) (PEG) chain engineer well-defined nanostructured assemblies within single-molecular framework. PTO-Biotin Nps possesses selective tropism lysosome accumulation inside cells, accommodated by its enhanced activity in acidic microenvironment. Upon activation, promoted dysfunction induced cytosolic acidification impaired autophagy. More importantly, photoactivation-mediated found markedly enhance cellular reactions ferroptosis, thereby improving antitumor efficacy mitigating systemic side effects. Overall, our study demonstrates that engineering enables modulation intrinsic mechanism, offering novel strategy for development metal-free inducers

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Nanosized Janus AuNR-Pt Motor for Enhancing NIR-II Photoacoustic Imaging of Deep Tumor and Pt²⁺ Ion-Based Chemotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7947 - 7960

Published: May 10, 2022

Synthetic micro/nanomotors have great potential in deep tissue imaging and vivo drug delivery because of their active motion ability. However, applying nanomotors with a size less than 100 nm to therapy is one the core changes this field. Herein, nanosized hydrogen peroxide (H2O2)-driven Janus gold nanorod-platinum (JAuNR-Pt) nanomotor developed for enhancing second near-infrared region (NIR-II) photoacoustic (PA) tissues tumors effective tumor treatment. The JAuNR-Pt prepared by depositing platinum (Pt) on end nanorod varying proportions Pt shell coverage, including 10%, 25%, 50%, 75%, 100%. coverage 50% exhibits highest diffusion coefficient (De), it can rapidly move presence H2O2. self-propulsion enhances cellular uptake, accelerates lysosomal escape, facilitates continuous release cytotoxic Pt2+ ions nucleus, causing DNA damage cell apoptosis. presents penetration enhanced accumulation as well high treatment effect. Therefore, work displays an excellent antitumor effect, providing tool accurate diagnosis diseases.

Language: Английский

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Discovery of BODIPY J-aggregates with absorption maxima beyond 1200 nm for biophotonics

Science Advances, Journal Year: 2022, Volume and Issue: 8(48)

Published: Dec. 2, 2022

Organic dyes with absorption maxima in the second near-infrared window (NIR-II; 1000 to 1700 nm) are of great interest biophotonics. However, because lack appropriate molecular scaffolds, current research this field is limited cyanine dyes, and developing NIR-II-absorbing organic for biophotonics remains an immense challenge. Here, we rationally designed ethenylene-bridged BODIPY scaffold featuring excellent J-aggregation capabilities revealed that bridging ethylene unit crucial intermolecular J-coupling regulation. By integrating electron-donating groups into scaffold, obtained a dye, BisBDP2, J-aggregate maximum around 1300 nm. BisBDP2 J-aggregates show photothermal performance, including intense photoacoustic response, high conversion efficiency value 63%. In vivo results demonstrate potential imaging ablation deep-seated tumors. This study will speed up exploration future biophotonic applications.

Language: Английский

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Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 17, 2023

Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual-acceptor engineering strategy exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π-conjugation degrees, making full use active intramolecular motion-induced effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, extremely satisfactory behavior. Consequently, unprecedented performance NPs 1064 nm laser-excited photoacoustic imaging (PAI)-guided therapy (PTT) demonstrated tumor diagnosis complete elimination.

Language: Английский

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