Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 11, 2023

Abstract The frequent outbreak of global infectious diseases has prompted the development rapid and effective diagnostic tools for early screening potential patients in point-of-care testing scenarios. With advances mobile computing power microfluidic technology, smartphone-based health platform drawn significant attention from researchers developing devices that integrate optical detection with artificial intelligence analysis. In this article, we summarize recent progress these platforms, including aspects chips, imaging modalities, supporting components, software algorithms. We document application platforms terms objects, molecules, viruses, cells, parasites. Finally, discuss prospects future platforms.

Language: Английский

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Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 18, 2022

As the indispensable second cellular messenger, calcium signaling is involved in regulation of almost all physiological processes by activating specific target proteins. The importance ions (Ca

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Language: Английский

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Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 10979 - 10993

Published: June 19, 2022

Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 agonist, is commonly used in clinical settings immune adjuvant. We prepared activatable sonodynamic sensitizer platform (MR) based on glutathione-sensitive disulfide bonds linking Leu-MB, the reduced form of methylene blue (MB), and R837 to achieve efficient combinatory SDT immunotherapy tumors without harming normal tissues. also amphiphilic polymer C18PMH-PEG create self-assembled MB-R837-PEG (MRP) nanoparticles immunosonodynamic (iSDT). iSDT cancer that combines immunotherapy. Our demonstrated excellent effect only at tumor site, demonstrating high specificity killing cells when compared reported literature. The improves its tumor-killing by inducing response, which accomplished secreted adjuvants site. MRP was selectively activated glutathione microenvironment release MB R837, exhibiting antitumor responses. In addition, combined with α-PD-L1 antibody checkpoint blockade, this effectively inhibited metastasis. mice treated did not develop even after reinoculation, indicating long-term memory achieved. concept preparation next-generation synergistic therapeutic modality applicable near future presented study.

Language: Английский

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Electrochemiluminescence metal-organic frameworks biosensing materials for detecting cancer biomarkers

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 157, P. 116735 - 116735

Published: July 12, 2022

Language: Английский

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ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 21, 2024

Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels cause oxidative damage to cells. A core-shell nanozyme, CeO

Language: Английский

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Designing a Mitochondria-Targeted Theranostic Cyclometalated Iridium(III) Complex: Overcoming Cisplatin Resistance and Inhibiting Tumor Metastasis through Necroptosis and Immune Response

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 3843 - 3859

Published: March 5, 2024

To develop a potential theranostic metal agent to reverse the resistance of cancer cells cisplatin and effectively inhibit tumor growth metastasis, we proposed design cyclometalated iridium (Ir) complex based on properties environment (TME). end, designed synthesized series Ir(III) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes by modifying hydrogen atom(s) N-3 position compounds structure dimers then investigated their structure–activity structure–fluorescence relationships obtain an (Ir5) with remarkable fluorescence cytotoxicity cells. Ir5 not only possesses mitochondria-targeted but also overcomes inhibits metastasis in vivo. Besides, confirmed anticancer mechanisms acting different components TME: directly killing liver inducing necroptosis activating necroptosis-related immune response.

Language: Английский

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Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7547 - 7566

Published: July 1, 2024

Abstract: Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, narrow therapeutic window, unfavorable pharmacokinetic properties. To solve above problems, target drug delivery tumor cells, reduce side effects drugs, an anti-tumor system based on microenvironment has become focus research in recent years. The construction reduction-sensitive nanomedicine disulfide bonds attracted much attention. Disulfide good reductive responsiveness can effectively high glutathione (GSH) levels environment, enabling precise delivery. further enhance targeting accelerate release, are often combined with pH-responsive nanocarriers highly expressed ligands cells construct systems. connect molecules polymer system, as well between different carrier molecules. This article summarized systems (DDS) that researchers constructed years bond microenvironment, cleavage-triggering conditions, various loading strategies, design. In this review, we also discuss controlled release mechanisms these DDS clinical applicability challenges faced translation. Keywords: bond, systems, GSH/ROS

Language: Английский

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Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(5), P. 2202 - 2218

Published: June 10, 2022

Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord are essential causes of death long-term disability difficult to cure, mainly due the limited neuron regeneration glial scar formation. Herein, we apply extracellular vesicles (EVs) secreted by M2 microglia improve differentiation neural stem cells (NSCs) at injured site, simultaneously modify them with vascular targeting peptide (DA7R) cell recruiting factor (SDF-1) on their surface via copper-free click chemistry recruit NSCs, inducing neuronal differentiation, serving as nanocarriers site (Dual-EV). Results prove that Dual-EV could target human umbilical endothelial (HUVECs), promote NSCs in vitro. Furthermore, 10 miRNAs found be upregulated Dual-M2-EVs compared Dual-M0-EVs bioinformatic analysis, further NSC experiment flow cytometry reveals among these miRNAs, miR30b-3p, miR-222-3p, miR-129-5p, miR-155-5p may exert effect differentiate into neurons. In vivo experiments show achieve improved accumulation ischemic area stroke model mice, potentiate recruitment, increase neurogenesis. This work provides new insights for treatment after CNS injuries well endogenous cells, EV/peptide/chemokine related improving health.

Language: Английский

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