Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

Citations

126
Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity DOI Creative Commons
Yongjiang Li, Wei Chen, Yong Kang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 1, 2023

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, display mild photothermal properties in situ denature collagen facilitate deep into mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by boosts immunity. In mouse models malignant TNBC hepatocellular carcinoma (HCC), combination robust SDT enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. study presents an innovative enhance immunity using strategy, offering potential combined sono-immunotherapy nanomedicine field.

Language: Английский

Citations

96
Activatable fluorescent probes for real-time imaging-guided tumor therapy DOI
Qi-Jia Duan,

Zhongyi Zhao,

Yaojun Zhang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114793 - 114793

Published: March 22, 2023

Language: Английский

Citations

95
Organic Sonodynamic Materials for Combination Cancer Immunotherapy DOI
Chi Zhang, Kanyi Pu

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: June 1, 2023

Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality to treat deep-seated tumors owing the good tissue penetration ability and spatiotemporal controllability of ultrasound (US); however, low sonodynamic activity potential side effects greatly limit its clinical translation. Cancer immunotherapy that leverages immune system fight against cancer has great synergize with SDT for treatment high efficiency safety. In this review, convergence exert their merits break through limitations combination sono-immunotherapy are discussed. The focus on development construction organic materials immunotherapeutic efficiency. These not only induce immunogenic cell death improve tumor immunogenicity via but also activate antitumor immunity immuno-oncology drug-mediated pathway modulation. various drugs sonosensitizers categorized discussed along prospects challenges

Language: Английский

Citations

72
Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy DOI
Bijiang Geng, Jinyan Hu,

Xialing He

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 16, 2024

The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy new treatment modality that can reverse TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia TME. Herein, this work reports sono-immunotherapy strategy using Pd

Language: Английский

Citations

49
Zinc–Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy Therapy DOI
Yujie Lu, Youdong Chen,

Guanghui Hou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10542 - 10556

Published: April 1, 2024

Immunotherapy has emerged as a potential approach for breast cancer treatment. However, the rigid stromal microenvironment and low immunogenicity of tumors strongly reduce sensitivity to immunotherapy. To sensitize patients immunotherapy, hyaluronic acid-modified zinc peroxide–iron nanocomposites (Fe-ZnO2@HA, abbreviated FZOH) were synthesized remodel increase tumor immunogenicity. The constructed FZOH spontaneously generated highly oxidative hydroxyl radicals (·OH) that degrade acid (HA) in extracellular matrix (ECM), thereby reshaping enhancing blood perfusion, drug penetration, immune cell infiltration. Furthermore, not only triggers pyroptosis through activation caspase-1/GSDMD-dependent pathway but also induces ferroptosis various mechanisms, including increasing levels Fe2+ intracellular iron pool, downregulating expression FPN1 inhibit efflux, activating p53 signaling cause failure SLC7A11-GSH-GPX4 axis. Upon treatment with FZOH, 4T1 cells undergo both pyroptosis, exhibiting strong immunogenic response. remodeling response induced by collectively compensate limitations immunotherapy significantly enhance antitumor checkpoint inhibitor αPD-1. This study proposes perspective therapy cancer.

Language: Английский

Citations

28
Exosome‐Inhibiting Polymeric Sonosensitizer for Tumor‐Specific Sonodynamic Immunotherapy DOI
Jiayan Wu, Jingsheng Huang, Jie Yu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 6, 2024

Combination cancer immunotherapy based on electromagnetic energy and shows potent anti-cancer efficacy. However, as a factor that mediates tumor metastasis immune suppression, the impact of exosomes therapy under stimulation remains unclear. Herein, findings indicate sonodynamic (SDT) increases serum exosome levels by inducing apoptotic loosening extracellular matrix, promoting lung metastasis. To address this problem, an exosome-inhibiting polymeric sonosensitizer (EIPS) selectively inhibiting generation in response to biomarker is synthesized. EIPS consists semiconducting polymer backbone capable SDT poly(ethylene glycol) layer conjugated with tumor-specific enzyme-responsive inhibitor prodrug. After being cleaved Cathepsin B, releases active inhibitors, preventing exosome-mediated suppression As result, elicits robust antitumor effects through synergistic effect inhibition, completely establishing long-term memory effect. This first example showing combining inhibition can elicit without help typical agonists.

Language: Английский

Citations

22
Immunological nanomaterials to combat cancer metastasis DOI

Yuanbo Pan,

Junjie Cheng, Yang Zhu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444

Published: Jan. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Language: Английский

Citations

21
Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy DOI Creative Commons
Zhiguang Chen, Liang Sang, Yanjun Liu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Language: Английский

Citations

3
THQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores DOI Creative Commons
Zhiqiang Mao, Hyeonji Rha, Jungryun Kim

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 28, 2023

Near-infrared fluorescence imaging is vital for exploring the biological world. The short emissions (<650 nm) and small Stokes shifts (<30 of current xanthene dyes obstruct their applications since a long time. Recently, potent universal THQ structural modification technique that emission to NIR-I/II range enables substantial shift (>100 THQ-modified established. Thus, timely discussion THQ-xanthene its extensive. Hence, advent, working principles, development trajectory, dyes, especially in fields probe-based sensing imaging, cancer theranostics, super-resolution are introduced. It envisioned tactic simple yet exceptional approach upgrade performance conventional dyes. will advance strides xanthene-based potentials early fluorescent diagnosis diseases, imaging-guided surgery.

Language: Английский

Citations

39