Mitochondria-Targeting AIEgens as Pyroptosis Inducers for Boosting Type-I Photodynamic Therapy of Tongue Squamous Cell Carcinoma DOI
Ying Peng,

Rufan Mo,

Mingwang Yang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

The development of a photosensitizer (PS) that induces pyroptosis could be star for photodynamic therapy (PDT), particularly with type-I PSs produce reactive oxygen species (ROS) in hypoxic tumor microenvironment. Since is recently characterized cell death pathway, it holds promise advancing PDT oncology, playing critical role. Herein, we develop PS named Th-M aggregation-induced emission (AIE) characteristics against tongue squamous carcinoma (TSCC). stands out its exceptional mitochondrial-targeting ability, which triggers mitochondrial dysfunction and leads to Caspase-3 Gasdermin E (GSDME) cleavage under white light irradiation, inducing TSCC cells. Our studies verify the effectiveness destroying cancer cells vitro suppressing growth vivo while also demonstrating favorable biosafety profile. This work pioneers application as mitochondria-targeted, leverages mechanism pyroptosis, offering potent approach treatment TSSC promising implications future cancers.

Language: Английский

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects DOI

Shuang Zeng,

Xiaosheng Liu, Yves S. Kafuti

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5607 - 5651

Published: Jan. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Language: Английский

Citations

165
Polydopamine, harness of the antibacterial potentials-A review DOI Creative Commons
Xiaojun He, Enoch Obeng, Xiaoshuai Sun

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 15, P. 100329 - 100329

Published: June 1, 2022

Antibiotic resistance is one of the major causes morbidity and mortality, triggered by adhesion microbes to some extent formation biofilms. This condition has been quite challenging in health industrial sector. Conditions processes required foil these infectious are much concern. The synthesis PDA material, inspired Mytilus edulis foot protein (MEFP)5 possesses unique characteristics that allow for, adhesion, photothermal therapy, synergistic effects with other materials, biocompatibility process, etc. Therefore, their usage holds great potential for dealing both nature antibiotic processes. Hence, this review provides an overview mechanism involved accomplishing eradicating bacteria, recently harnessed antibacterial effect through properties they possess, a way forward tapping benefit embedded PDA, future perspective.

Language: Английский

Citations

80
A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers DOI
Xiaoliang Qi,

Yizuo Shi,

Chaofan Zhang

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547

Published: May 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Language: Английский

Citations

79
Photodynamic and photothermal therapies for bacterial infection treatment DOI Creative Commons
Heejeong Kim, You Rim Lee, Hyunsun Jeong

et al.

Smart Molecules, Journal Year: 2023, Volume and Issue: 1(1)

Published: May 16, 2023

Abstract Bacteria can cause numerous infectious diseases and has been a major threat to human humans. Although antibiotics have partially succeeded in treating bacteria, owing antibiotic abuse, the emergence of multidrug‐resistant (MDR) bacteria drastically diminished their potency. Since invention laser, combination light photosensitizers, photodynamic therapy (PDT), become an effective noninvasive treatment along with photothermal (PTT), which heat is generated by nonradiative relaxation. Antimicrobial PDT PTT are emerging as treatments for bacterial infection, particularly against MDR bacteria. This mini review covers recent progresses treatment.

Language: Английский

Citations

78
Initiative ROS generation of Cu-doped ZIF-8 for excellent antibacterial performance DOI
Xiaoze Wang, Hui Wang,

Jiafan Cheng

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 143201 - 143201

Published: April 26, 2023

Language: Английский

Citations

76
Catalyzing innovation: Exploring iron oxide nanoparticles - Origins, advancements, and future application horizons DOI
Pankaj Kumar, Nikesh Thakur, Kuldeep Kumar

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 507, P. 215750 - 215750

Published: Feb. 29, 2024

Language: Английский

Citations

48
Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications DOI
Xiaofeng Wu, Jingjing Hu, Juyoung Yoon

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(18)

Published: Feb. 19, 2024

The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction information exchange. Therefore, disrupting its structure or impairing functions can potentially cause irreversible damage. Presently, the tumor recognized as promising therapeutic target for various treatment methods. Given extensive research focused on membranes, it both necessary timely to discuss these developments, from materials design specific biomedical applications. This review covers treatments based functional targeting membrane, ranging well-known membrane-anchoring photodynamic therapy recent lysosome-targeting chimaeras protein degradation. diverse mechanisms are introduced in following sections: phototherapy, self-assembly situ biosynthesis degradation proteins by chimeras. In each section, we outline conceptual general derived numerous studies, emphasizing representative examples understand advancements draw inspiration. Finally, some challenges future directions membrane-targeted our perspective. aims engage multidisciplinary readers encourage researchers related fields advance fundamental theories practical applications membrane-targeting agents.

Language: Английский

Citations

26
Spin‐state Conversion by Asymmetrical Orbital Hybridization in Ni‐doped Co3O4 to Boost Singlet Oxygen Generation for Microbial Disinfection DOI

Meilin Duan,

Chao Huang,

Gong Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Jan. 25, 2024

Singlet oxygen (1 O2 ) plays a significant role in environmental and biomedical disinfection fields. Electrocatalytic processes hold great potential for 1 generation, but remain challenging. Herein, facile Ni doping converted spin-state transition approach is reported boosting production. Magnetic analysis theoretical calculations reveal that occupied at the octahedral site of Co3 O4 can effectively induce low-to-high transition. The high-spin Ni-Co3 generate appropriate binding strength enhance electron transfer between Co centers with intermediates, thereby improving catalytic activity effective generating . In neutral conditions, 1×106 CFU mL-1 Gram-negative ESBL-producing Escherichia coli (E. coli) could be inactivated by system within 5 min. Further antibacterial mechanisms indicate lead to cell membrane damage DNA degradation so as irreversible death. Additionally, developed inactivate bacteria from wastewater bioaerosols. This work provides an strategy designing electrocatalysis boost generation process.

Language: Английский

Citations

24
Charge Regulation-Enhanced Type I Photosensitizer-Loaded Hydrogel Dressing for Hypoxic Bacterial Inhibition and Biofilm Elimination DOI
Tao Xiong,

Fangrui Ning,

Yingchao Chen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm-induced chronic bacterial infections represent a significant challenge in modern medicine due to their resistance conventional antibiotic treatments. Although photodynamic therapy (PDT) has emerged as promising antibiotic-free antibacterial strategy, the hypoxic condition within biofilms and lack of an effective local drug delivery system have limited clinical effectiveness photosensitizer (PS) agents. Herein, we propose type charge regulation-enhanced I PS-loaded hydrogel dressing for treating biofilm infection. The regulation enables multiple alkylation Nile blue (EB series) exhibit substantially improved absorbance (∼2-fold), alkaline tolerance, superoxide anion yield (2.2-4.2-fold) compared representative PS, sulfur-substituted blue. Specifically, enhanced electronic push-pull capabilities promote more efficient electron recycling process, significantly boosting efficiency PDT. superior PDT effect uptake via render EB series pronounced inhibition under red light or sunlight irradiation. Moreover, hydrogel, constructed from oxidized dextran quaternized chitosan, facilitates localization sustained retention PSs, accelerating healing biofilm-infected wounds. This PS-based could provide user-friendly wound treatment prevention infections.

Language: Английский

Citations

5
Construction of Rhodamine‐Based AIE Photosensitizer Hydrogel with Clinical Potential for Selective Ablation of Drug‐Resistant Gram‐Positive Bacteria In Vivo DOI

Shuang Zeng,

Zuokai Wang, Chen Chen

et al.

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(17)

Published: June 25, 2022

Abstract The emergence of powerful antibiotic‐resistant bacteria caused by the abuse antibiotics has become a public health problem. Photodynamic antibacterial therapy is regarded as an innovative and promising approach due to its minor side effects lack drug resistance. Nevertheless, few photosensitizers (PSs) are reported have near‐infrared (NIR) emission, ability rapidly discriminate bacteria, high photodynamic efficiency. In this study, it for first time that water‐soluble NIR fluorescence emission rhodamine‐based photosensitizer with aggregation‐inducing (AIE) effects, referred CS‐2I, can efficiently identify kill Gram‐positive bacteria. imaging experiment blended CS‐2I selectively target specifically label efficiency after only 5 min incubation. Furthermore, achieves complete inhibition methicillin‐resistant Staphylococcus aureus (MRSA) at extremely low concentration (0.5 µ m ) light dosage (6 J cm −2 ). Remarkably, mixed Carbomer 940 prepare hydrogel dressing (CS‐2I@gel), in vitro vivo results demonstrate CS‐2I@gel provides extraordinary performance therapy. Hence, study new strategy blueprint future design materials.

Language: Английский

Citations

46