An ER‐targeted, Viscosity‐sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(9)

Published: Jan. 10, 2024

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend modern medical advancement. Herein, we rationally designed smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis treatment in cell animal models by combining hemicyanine dyes ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability target ER a highly specific response viscosity, demonstrated substantial fluorescence turn-on only after binding ER, independent other physiological environments. In addition, ER-ZS, being small molecule, allows nonalcoholic fatty liver disease (NAFLD) via imaging based on high stress. Importantly, is type I photosensitizer, producing O

Language: Английский

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Bienzyme-Locked Activatable Fluorescent Probes for Specific Imaging of Tumor-Associated Mast Cells

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(18), P. 12656 - 12663

Published: April 29, 2024

Tumor-associated mast cells (TAMCs) have been recently revealed to play a multifaceted role in the tumor microenvironment. Noninvasive optical imaging of TAMCs is thus highly desired gain insights into their functions cancer immunotherapy. However, due lack single enzyme that specific cells, common probe design approach based on single-enzyme activation not applicable. Herein, we reported bienzyme-locked molecular (THCMC) photoinduced electron transfer-intramolecular charge-transfer hybrid strategy for vivo TAMCs. The mechanism ensures THCMC exclusively turns near-infrared (NIR) fluorescence only presence both tryptase and chymase specifically coexpressed by cells. Thus, effectively distinguishes from other leukocytes, including T neutrophils, macrophages, capability lacking single-locked probes. Such high specificity allows noninvasive tracking fluctuation living mice during results reveal decreased intratumoral signal after combination immunotherapy correlates well with reduced population TAMCs, accurately predicting inhibition growth. this study presents first NIR fluorescent but also proposes generic cell imaging.

Language: Английский

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Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215786 - 215786

Published: March 20, 2024

Language: Английский

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Chelation strategies in spiropyran-based chemosensors for colorimetric and fluorescent sensing of metal ions and anions

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215779 - 215779

Published: March 14, 2024

Language: Английский

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Recent advances in the design of organic photothermal agents for cancer treatment: A review

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215719 - 215719

Published: Feb. 24, 2024

Language: Английский

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A Dual Fluorescence Turn‐On Sensor Array Formed by Poly(para‐aryleneethynylene) and Aggregation‐Induced Emission Fluorophores for Sensitive Multiplexed Bacterial Recognition

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(16)

Published: Feb. 26, 2024

Bacterial infections have emerged as the leading causes of mortality and morbidity worldwide. Herein, we developed a dual-channel fluorescence "turn-on" sensor array, comprising six electrostatic complexes formed from one negatively charged poly(para-aryleneethynylene) (PPE) positively aggregation-induced emission (AIE) fluorophores. The 6-element array enabled simultaneous identification 20 bacteria (OD

Language: Английский

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Dissecting lysosomal viscosity fluctuations in live cells and liver tissues with an ingenious NIR fluorescent probe

Talanta, Journal Year: 2024, Volume and Issue: 272, P. 125825 - 125825

Published: Feb. 23, 2024

Language: Английский

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Less is More: Asymmetric D‐A Type Agent to Achieve Dynamic Self‐Assembled Nanoaggregates for Long‐Acting Photodynamic Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 30, 2024

Abstract To enhance the phototheranostic performance, agents with high reactive oxygen species (ROS) generation, good tumor‐targeting ability, and prolonged retention are urgently needed. However, symmetric donor–acceptor (D–A) type usually produce spherical nanoaggregates, leading to tumor targeting but inferior retention. Rod‐like nanoaggregates desired extend their in tumors; however, this remains a challenge. In particular, dynamically changeable shapes that integrate merits of different morphologies seldomly reported. Therefore, self‐assembled organic smart shape tunability designed here using an asymmetric D–A TIBT. The photoluminescence quantum yield solids is up 52.24% for TIBT also exhibits ROS generation corresponding (TIBT‐NCs). Moreover, dynamic self‐assembly changing from nanospheres nanorods occurrs TIBT‐NCs, contributing enhancement 0.55 0.72. addition, can be observed both vitro vivo, conferring TIBT‐NCs strong Finally, efficient photodynamic therapy inhibit growth achieved inhibition rate 90%. This work demonstrates play significant roles forming thus showing great potential long‐acting cancer therapy.

Language: Английский

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General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Language: Английский

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Mitochondria-targetable small molecule fluorescent probes for the detection of cancer-associated biomarkers: A review

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1289, P. 342060 - 342060

Published: Nov. 25, 2023

Language: Английский

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