npj Flexible Electronics,
Journal Year:
2023,
Volume and Issue:
7(1)
Published: Aug. 28, 2023
Abstract
Photodynamic
therapy
(PDT)
is
attracting
attention
as
a
next-generation
cancer
treatment
that
can
selectively
destroy
malignant
tissues,
exhibit
fewer
side
effects,
and
lack
pain
during
treatments.
Implantable
PDT
systems
have
recently
been
developed
to
resolve
the
issues
of
bulky
expensive
conventional
implement
continuous
repetitive
treatment.
Existing
implantable
systems,
however,
are
not
able
perform
multiple
functions
simultaneously,
such
modulating
light
intensity,
measuring,
transmitting
tumor-related
data,
resulting
in
complexity
Here,
we
introduce
flexible
fully
wireless
optoelectronic
system
capable
effective
by
fusing
hyperthermia
enabling
tumor
size
monitoring
real-time.
This
exploits
micro
inorganic
light-emitting
diodes
(μ-LED)
emit
with
wavelength
624
nm,
designed
affect
surrounding
normal
tissues
utilizing
programmable
intensity
μ-LED
precisely
Si
phototransistor
long-term
implantation
(2–3
weeks).
The
superiority
simultaneous
capabilities
our
operated
power
data
transmissions
cell
phone
was
confirmed
through
vitro
experiments,
ray-tracing
simulation
results,
xenograft
mouse
model
vivo.
all-in-one
single
for
offers
opportunities
only
enable
tumors
located
deep
tissue
but
also
precise
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 4081 - 4087
Published: Feb. 13, 2023
The
highly
oxygen-dependent
nature
of
photodynamic
therapy
(PDT)
limits
its
therapeutic
efficacy
against
hypoxic
solid
tumors
in
clinics,
which
is
an
urgent
problem
to
be
solved.
Herein,
we
develop
oxygen-independent
supramolecular
agent
that
produces
hydroxyl
radical
(•OH)
by
oxidizing
water
the
presence
intracellularly
abundant
pyruvic
acid
under
oxygen-free
conditions.
A
fluorene-substituted
BODIPY
was
designed
as
electron
donor
and
coassembled
with
perylene
diimide
acceptor
form
quadruple
hydrogen-bonded
agent.
Detailed
mechanism
studies
reveal
intermolecular
transfer
charge
separation
upon
light
irradiation
result
efficient
generation
ion
pairs.
Under
conditions,
cationic
radicals
directly
oxidize
generate
cytotoxic
•OH,
anionic
electrons
acid,
realizing
catalytic
cycle.
Thus,
this
exhibited
superb
photocytotoxicity
even
severe
environments
excellent
vivo
antitumor
on
HeLa-bearing
mouse
models.
This
work
provides
a
strategy
for
constructing
agents,
opens
up
avenue
effective
PDT
tumors.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(18)
Published: Nov. 18, 2022
Abstract
The
use
of
boron
dipyrromethene
(BODIPY)
in
biomedicine
is
reviewed.
To
open,
its
synthesis
and
regulatory
strategies
are
summarized,
inspiring
cutting‐edge
work
post‐functionalization
highlighted.
A
brief
overview
assembly
model
BODIPY
then
provided:
introduced
as
a
promising
building
block
for
the
formation
single‐
multicomponent
self‐assembled
systems,
including
nanostructures
suitable
aqueous
environments,
thereby
showing
great
development
potential
supramolecular
applications.
frontier
progress
biomedical
application
thereafter
described,
supported
by
examples
frontiers
applications
BODIPY‐containing
smart
materials:
it
mainly
involves
materials
based
on
blocks
their
assemblies
fluorescence
bioimaging,
photoacoustic
imaging,
disease
treatment
photodynamic
therapy,
photothermal
immunotherapy.
Lastly,
not
only
current
status
family
field
but
also
challenges
worth
considering
summarized.
At
same
time,
insights
into
future
prospects
biomedically
applicable
provided.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 3976 - 4019
Published: Jan. 1, 2024
This
review
focuses
on
the
design
strategy,
spectroscopic
characteristics,
and
functionalization
of
mitochondrion-targeted
BODIPY
dyes,
providing
an
overview
these
dyes
for
bioimaging
photodynamic
therapy.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(12)
Published: Jan. 23, 2024
We
herein
present
an
approach
of
photo-induced
disproportionation
for
preparation
Type-I
photodynamic
agents.
As
a
proof
concept,
BODIPY-based
photosensitizers
were
rationally
designed
and
prepared.
The
intermolecular
electron
transfer
between
homotypic
chromophores
leads
to
the
reaction,
resulting
in
formation
charged
intermediates,
cationic
anionic
radicals.
radicals
efficiently
oxidize
cellularimportant
coenzyme,
tetrahydrobiopterin
(BH
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 6252 - 6265
Published: Feb. 20, 2024
Conventional
photodynamic
therapy
(PDT)
is
often
limited
in
treating
solid
tumors
due
to
hypoxic
conditions
that
impede
the
generation
of
reactive
oxygen
species
(ROS),
which
are
critical
for
therapeutic
efficacy.
To
address
this
issue,
a
fractionated
PDT
protocol
has
been
suggested,
wherein
light
irradiation
administered
stages
separated
by
dark
intervals
permit
recovery
during
these
breaks.
However,
current
photosensitizers
used
incapable
sustaining
ROS
production
intervals,
leading
suboptimal
outcomes
(Table
S1).
circumvent
drawback,
we
have
synthesized
novel
photosensitizer
based
on
triple-anthracene
derivative
designed
prolonged
generation,
even
after
cessation
exposure.
Our
study
reveals
unique
action
derivatives,
facilitating
direct
and
effective
disruption
biomolecules
significantly
improving
efficacy
S2).
Moreover,
existing
lack
imaging
capabilities
monitoring,
constraints
fine-tuning
parameters
also
serves
as
an
afterglow
agent,
emitting
sustained
luminescence
postirradiation.
This
function
allows
precise
optimization
between
sessions
aids
determining
timing
subsequent
irradiation,
thus
enabling
meticulous
control
over
parameters.
Utilizing
our
photosensitizer,
formulated
regimen
effectively
eliminates
orthotopic
pancreatic
tumors.
investigation
highlights
promise
employing
long-persistent
activity
advanced
approaches
overcome
limitations
tumor
treatment.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(44)
Published: Sept. 13, 2022
Spatial
electronic
communications
of
chromophores
are
both
theoretically
and
practically
fascinating.
Despite
intramolecular
or
intermolecular
exciton
coupling
was
observed
in
multichromophoric
oligomers
J-aggregates,
respectively,
it
is
unusual
that
they
occur
the
same
molecule.
Herein,
ethene-bridged
aza-BODIPY
dimers
with
splitting
have
been
developed.
By
encapsulating
dimer
into
F-127
polymer,
J-type
aggregated
nanoparticles
were
produced,
which
showed
obvious
dramatically
redshifted
absorption
emission
peaks
at
936
1003
nm,
respectively.
The
fabricated
nanoagents
high
photothermal
conversion
ability
(η=60.3
%)
ultra-photostable,
leading
to
complete
tumor
ablation
915
nm
laser
irradiation.
This
phototherapeutic
nanoplatform
through
modulating
intra-
couplings
a
valuable
paradigm
for
developing
agents
treatment.
