Supramolecular‐Assembly and Surfactant‐Regulated Circularly Polarized Luminescence from a Spiranic BINOL‐Derived Borate Isoindolyl‐Indolenine (BBI) Dye DOI

Yingzhu Sun,

Changjiang Yu, Tingting Yu

et al.

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Circularly polarized luminescence (CPL) materials have attracted significant attention owing to their unique luminescent properties and broad range of applications. However, challenges remain, including controlling helical assembly, mitigating aggregation‐caused quenching, balancing quantum yield ( Φ PL ) with g values. Here, the study reports synthesis a novel asymmetric, spiranic O‐organoboranes bearing isoindolyl‐indolenine scaffold (BBI) axial chirality through BINOL substitution, as well its supramolecular assembly surfactant‐regulated tunable CPL behaviors. The newly designed BBI dye shows relative weak 10% in toluene. Supramolecular acetonitrile/water co‐solvents exhibit an obvious aggregation‐induced emission (AIE) process, leading formation spherical nanostructures red‐shifted orange‐yellow (554 nm, = 0.012, 7%). Moreover, surfactant sodium dodecyl sulfonate (SDS) can promote aggregation pure deionized water, producing nanofibers blue‐shifted yellow (536 0.006, 13%). Crystal growth toluene/hexane SDS aqueous/acetonitrile systems reveals chiral crystals P 212121 space group, offering insights into amplification. This demonstrates ability precisely control parameters, X‐ray single‐crystal analysis providing additional understanding regulation.

Language: Английский

Catalytic asymmetric C–N cross-coupling towards boron-stereogenic 3-amino-BODIPYs DOI Creative Commons
Baoquan Zhan, Li‐Qing Ren,

Jiayi Zhao

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 7, 2025

3-Amino boron dipyrromethenes (BODIPYs) are a versatile class of fluorophores widely utilized in live cell imaging, photodynamic therapy, and fluorescent materials science. Despite the growing demand for optically active BODIPYs, synthesis chiral 3-amino-BODIPYs, particularly catalytic asymmetric version, remains challenge. Herein, we report boron-stereogenic 3-amino-BODIPYs via palladium-catalyzed desymmetric C–N cross-coupling prochiral 3,5-dihalogen-BODIPYs. This approach features broad substrate scope, excellent functional group tolerance, high efficiency, remarkable enantioselectivities, under mild reaction conditions. Further stereospecific formation 3,5-diamino-BODIPYs, along with an investigation into photophysical properties resulting optical BODIPYs also explored. protocol not only enriches chemical space chiroptical BODIPY dyes but contributes to realm chemistry. (BODIPYs), which useful science, authors first cross-couplings.

Language: Английский

Citations

3
Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis DOI
Xingyu Zhao,

Jiaping Shen,

Huixuan Qi

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 291 - 303

Published: Jan. 17, 2025

Language: Английский

Citations

2
Phototherapy: progress, challenges, and opportunities DOI
Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

14
Supramolecular assembly boosting the phototherapy performances of BODIPYs DOI
Ying Dai, Jifu Sun, Xue Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 216054 - 216054

Published: July 2, 2024

Language: Английский

Citations

13
Recent advances in low‐background luminescent nanomaterials‐enhanced lateral flow assays for clinical diagnosis DOI Creative Commons

Liangwen Hao,

Jing Chen,

Quanshuang Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.

Language: Английский

Citations

1
Xanthene-Based NIR organic phototheranostics agents: Design strategies and biomedical applications DOI
Xiao‐Yun Ran, Yuanfeng Wei, Yanling Wu

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Near-infrared fluorescence imaging is key in biological exploration. Short emission wavelengths of xanthene dyes limit their use. Structural modifications shift emissions to the NIR-I/II range, enhancing biomedical applications.

Language: Английский

Citations

1
Construction of Through‐Space Charge‐Transfer Nanoparticles for Facilely Realizing High‐Performance NIR‐II Cancer Phototheranostics DOI Creative Commons
Ka‐Wai Lee,

Yijian Gao,

Shu‐Hua Chou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Phototheranostics with second near‐infrared (NIR‐II) emissions show great potential for disease diagnosis and imaging‐guided phototherapy owing to deep tissue penetration, high imaging resolution, excellent tumor eradication. Recently, molecular conjugation engineering J‐aggregation have been used construct organic NIR‐II materials. However, these molecules generally extensive large weight in the range of 700–1700 g mol −1 , requiring complicated design synthesis. Herein, a emissive through‐space charge‐transfer (TSCT) nanoparticle (NP) using short‐conjugated donor‐acceptor (D‐A) (TTP) is reported high‐performance bioimaging cancer phototheranostics. Owing short TTP molecule small only 518 monomer possesses visible absorption first (NIR‐I) emission. Upon forming NPs water, efficient TSCT between monomers leads significantly red‐shifted NIR‐I emission region tail that extends 1400 nm. are employed vivo blood‐vessel phototheranostics successfully. This work introduces facile strategy based on D‐A biomedical applications.

Language: Английский

Citations

5
Pyrazole appended Schiff base based sensor for Al3+detection: spectroscopic investigation, real sample analysis and cell imaging studies DOI
Bhriguram Das,

Krishna Chandra Murmu,

Surya Kanti Dey

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 170, P. 113108 - 113108

Published: Sept. 1, 2024

Language: Английский

Citations

4
Targeting Sub-Cellular Organelles for Boosting Precision Photodynamic Therapy DOI
G. Attar,

M. Kumar,

Vandana Bhalla

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.

Language: Английский

Citations

4
Aggregation-Induced Emission Luminogen Based Wearable Visible-Light Penetrator for Deep Photodynamic Therapy DOI
Kun Zhou, Ying Yu, Letian Xu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29930 - 29941

Published: Oct. 18, 2024

Photodynamic therapy (PDT) has emerged as a preferred nonsurgical treatment in clinical applications due to its capacity selectively eradicate diseased tissues while minimizing damage normal tissue. Nevertheless, efficacy is constrained by the limited penetration of visible light. Although near-infrared (NIR) lasers offer enhanced tissue penetration, dearth suitable photosensitizers and pronounced imaging-treatment disparity pose challenges. Additionally, implementation via optical fiber implantation carries infection risks necessitates minimally invasive surgery, contradicting PDT's noninvasive advantage. In this study, we introduce brilliant approach utilizing aggregation-induced emission luminogens (AIEgen) develop visible-light penetrator (VLP), coupled with wireless light emitting diodes (LEDs), enabling deep photodynamic therapy. We validate therapeutic inaccessible conventional PDT, demonstrating significant suppression inflammatory diffusion vivo using AIEgen TBPPM loaded within VLP, which exhibits transmittance 86% thickness 3 mm. This innovative effectively overcomes substantial limitations PDT settings holds promise for advancing phototherapy.

Language: Английский

Citations

4