Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 319, P. 121192 - 121192
Published: July 11, 2023
Language: Английский
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(3), P. 2062 - 2070
Published: Jan. 12, 2023
γ-Glutamyltransferase (GGT) has been recognized as an important clinical biomarker that is closely related to many diseases. Visualizing the GGT fluctuation facilitates early disease-related diagnosis and therapy. Herein, activated probe (NIR-GGT) for imaging of activity was prepared. The consists a stable NIR fluorophore with tunable amino group decorated γ-glutamate GGT-sensing unit linked by self-elimination group. NIR-GGT can sensitively recognize cause strong turn-on fluorescent photoacoustic signal. up-regulation expression in acetaminophen-induced acute liver injury imaged using NIR-GGT. track changes level stages drug-induced (DIALI) its remedy process dual-modality high temporal–spatial resolution. also be used differentiate between tumor para-carcinowa tissues vivo. may potential tool early-stage DIALI accurate resection field.
Language: Английский
Citations
29
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(30), P. 35884 - 35894
Published: July 24, 2023
The effect of photodynamic therapy (PDT) is severely limited by tumor hypoxia and the short half-life reactive oxygen species (ROS). Herein, we constructed a near-infrared (NIR) light-regulated PDT nanoplatform (TPP-UCNPs@MOF-Pt) consisting an upconversion nanoparticle (UCNP) core porphyrin-based metal-organic framework (MOF) shell with platinum nanoparticles (PtNPs) mitochondria-targeting triphenylphosphine (TPP) group on surface. TPP-UCNPs@MOF-Pt could effectively relieve converting intracellular H2O2 to (O2) elevated ROS level enhance efficacy under NIR light irradiation. In addition, was localized mitochondria, leading severe depolarization mitochondrial membrane activation apoptotic pathway, further amplifying therapeutic efficacy. vitro in vivo experiments demonstrated that greatly enhanced achieved combining relief targeting activation. This study provides promising strategy for construction MOF-based multifunctional address current limitations treatment hypoxic tumors.
Language: Английский
Citations
28
ACS Sensors, Journal Year: 2023, Volume and Issue: 8(2), P. 914 - 922
Published: Feb. 15, 2023
Drug-induced acute kidney injury (DIAKI) is associated with high morbidity and mortality. It remains a diagnostic therapeutic dilemma due to failure of providing unambiguous real-time feedback on nephrotoxicity, which regarded as serious problem in clinics. Herein, we report reversible fluorescence probe, NRN, monitor the ONOO–/GSH an model. The NRN near-infrared fluorescent probe features big Stokes shift (83 nm), was oxidized by ONOO– reduced succussive glutathione (GSH) excellent selectivity good sensitivity (detection limit: 418 nM 0.28 mM, respectively). Taking reversibility toward GSH, evaluations vivo cisplatin (CP) alone CP combined acetaminophen-stimulated following remedy process l-carnitine were realized for first time. experiments revealed that caused drugs might be more irreversible under certain conditions. Therefore, could act potential tool understanding oxidative stress-related DIAKI disease processes.
Language: Английский
Citations
27
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(19)
Published: Feb. 14, 2023
Hypoxia represents a remarkably exploitable target for cancer therapy, is encountered only in solid human tumors, and highly associated with resistance recurrence. Here, hypoxia-activated mitochondria-accumulated Ru(II) polypyridyl prodrug functionalized conjugated azo (Az) nitrogen mustard (NM) functionalities, RuAzNM, reported. This has multimodal theranostic properties toward hypoxic cells. Reduction of the group cell microenvironments gives rise to generation two primary amine products, free aniline mustard, RuNH2 complex. Thus, triggers reactive oxygen species (ROS) mtDNA crosslinking. Meanwhile, resultant biologically benign phosphorescent diagnostic signal signals activation phototherapy. therapeutic effect eventually elevates ROS levels, depletes reduced nicotinamide adenine dinucleotide (NADH) adenosine triphosphate (ATP), induces mitochondrial membrane damage, ultimately apoptosis. unique strategy allows controlled theranostics be realized cells multicellular spheroids, making RuAzNM selective effective cancer-cell-selective agent (IC50 = 2.3 µm HepG2 vs 58.2 normoxic THL-3 normal cells). first report metal-based compound developed as hypoxia.
Language: Английский
Citations
25
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
10
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3673 - 3692
Published: May 8, 2024
Copper (Cu) and Cu-based nanomaterials have received tremendous attention in recent years because of their unique physicochemical properties good biocompatibility the treatment various diseases, especially cancer. To date, researchers designed fabricated a variety integrated nanocomplexes with distinctive nanostructures applied them cancer therapy, mainly including chemotherapy, radiotherapy (RT), photothermal therapy (PTT), chemodynamic (CDT), photodynamic (PDT), cuproptosis-mediated etc. Due to limited effect single method, development composite diagnostic nanosystems that integrate PTT, CDT, PDT, other treatments is great significance offers potential for next generation anticancer nanomedicines. In view rapid field this review focuses on current state research nanomaterials, followed by discussion combined therapy. Moreover, challenges future prospects clinical translation are proposed provide some insights into design nanotherapeutic platforms.
Language: Английский
Citations
9
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 18, 2025
For cancer treatment, collaborative strategies have been the mainstream for overcoming restrictions resulting from monotherapy. Combining chemotherapy with photodynamic therapy (PDT) has shown to increase antitumor effect and reduce side impacts. This study reports a hypoxia-activated prodrug BOD-Azo-single PDT agent aniline mustard connected by azo bond. With light illumination, exhibited some PDT. Under hypoxic conditions, bond cleaved released BOD-3-single of higher phototoxicity chemotoxicity. In vivo therapeutic experiments showed that significantly reduced A375 tumor proliferation 92% TGI value. Overall, in this study, was employed address adverse systemic toxicity chemotoxicity made up inefficiency microenvironment, introducing new strategy developing combined agents be advantageous each other. environment, exerted strong synergistic (CI = 0.25), indicating is real bimodal chemo-photodynamic agent.
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(4), P. 2428 - 2435
Published: Jan. 17, 2023
Selective fluorescence imaging of analytes is a challenge for monitoring diseases as homologues interfere with the agents. Leucine aminopeptidase (LAP), kind protease, related to tumor pathogenesis. The known LAP fluorescent probes based on leucine recognition have limited selectivity. Herein, selective t-butyl-alanine unit through ligand regulation strategy prepared new near-infrared (NIR) probe (DCM-LAP) having large Stokes shift 214 nm and high sensitivity detection limit 168 mU/L. DCM-LAP has an enhanced response toward NIR at 656 intramolecular charge transfer. without being interfered by biological enzymes including N (APN). can image activity in living cells. It also visualize cell invasion migration processes. employed real-time tumor-bearing nude mice guides accurate resection breast tumors. distinguishes tissues from normal tumor-to-normal ratio (9.8). thus assist investigations LAP-associated clinical disease.
Language: Английский
Citations
20
Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 393, P. 134287 - 134287
Published: July 12, 2023
Language: Английский
Citations
19
National Science Review, Journal Year: 2024, Volume and Issue: 11(4)
Published: Feb. 5, 2024
ABSTRACT Tirapazamine (TPZ) has been approved for multiple clinical trials relying on its excellent anticancer potential. However, as a typical hypoxia-activated prodrug (HAP), TPZ did not exhibit survival advantages in Phase III when used combination therapy due to the insufficient hypoxia levels patients’ tumors. In this study, improve therapeutic effects of TPZ, we first introduced urea synthesize series urea-containing derivatives TPZ. All showed increased hypoxic cytotoxicity (9.51–30.85-fold) compared with while maintaining selectivity. TPZP, one these derivatives, 20-fold higher than similar ratio. To highly efficiently deliver TPZP tumors and reduce side healthy tissues, further prepared into nanodrug fibrin-targeting ability: FT11-TPZP-NPs. CA4-NPs, vascular disrupting agent, was increase fibrin level within exacerbate tumor hypoxia. By being combined FT11-TPZP-NPs can accumulate hypoxia-aggravated activate sufficiently kill cells. After single-dose treatment, + CA4-NPs high inhibition rate 98.1% against CT26 models an initial volume ∼480 mm3 four out six were completely eliminated; it thereby exerted significant antitumor effect. This study provides new strategy improving effect other HAPs therapy.
Language: Английский
Citations
8