Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(12)

Published: Jan. 11, 2023

Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis therapeutic meet the demands of precision medicine. The information effect are directly determined by fluorescence imaging ability photothermal conversion efficiency (PCE) phototheranostic agents. Hence, how balance competitive radiative nonradiative processes agents is key factor evaluate effect. Herein, molecules named ICRs with high photostaibility rationally designed, exhibiting emission in second near-infrared window (NIR-II, 1000-1700 nm) PCE, which related strong donor-acceptor (D-A) interaction reorganization energy Noteworthily, ICR-Qu stronger D-A large-sized conjugated unit encapsulated nanoparticles exhibits PCE (81.1%). In addition, ICR-QuNPs used (FLI), photoacoustic (PAI), (PTI) guide deep-tissue photonic hyperthermia, achieving removal inhibition breast cancer. Furthermore, combined α-PD-1, show huge potential be facile efficient tool photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based agent, but also sheds light on exploration versatile organic future practical applications.

Language: Английский

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J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

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Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

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Solvatochromic Near-Infrared Aggregation-Induced Emission-Active Acrylonitriles by Acceptor Modulation for Low-Power Stimulated Emission Depletion Nanoscopy

Chemistry of Materials, Journal Year: 2023, Volume and Issue: 35(6), P. 2472 - 2485

Published: Feb. 24, 2023

Stimulated emission depletion (STED) nanoscopy has broadened our horizons to unravel mysterious functions of cellular structures on an unparalleled nanometer scale. Nevertheless, intense laser power is a general prerequisite for STED super-resolution imaging with satisfactory resolution, inevitably leading severe photobleaching fluorophores, irreparable photodamage biosamples, and impaired quality. Herein, by modulating distinct acceptor units, series donor–acceptor–acceptor structured fluorescent acrylonitriles featured aggregation-induced (AIE) at low were systematically developed. These AIE luminogens (AIEgens) exhibited tunable near-infrared emissions (650–733 nm) high fluorescence quantum yields (QYs up 26.8%) in the solid state, significant Stokes shifts, large two-photon absorption cross-sections. They also typical solvatochromic effect ultrahigh QYs 98.4% low-polarity solvents. Furthermore, these lipophilic specifically lit lipid droplets (LDs) exceptionally photostability wash-free manner. By taking TPA-BT-ANBI as example, LDs excellent resolution 62 80 nm cytosolic nuclear LDs, respectively, saturation 0.83 MW/cm2 extended time-lapse LD dynamics was achieved. Subsequent use optical discrimination fatty liver tissues deep-tissue demonstrated. This study opens new avenues versatile photostable materials powers target-specific imaging.

Language: Английский

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A Self-degrading and NIR-II emissive type I/II photosensitizer with synergistic photodynamic and photothermal properties for antibacterial and anticancer

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 405, P. 135346 - 135346

Published: Jan. 15, 2024

Language: Английский

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Less is More: Asymmetric D‐A Type Agent to Achieve Dynamic Self‐Assembled Nanoaggregates for Long‐Acting Photodynamic Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 30, 2024

Abstract To enhance the phototheranostic performance, agents with high reactive oxygen species (ROS) generation, good tumor‐targeting ability, and prolonged retention are urgently needed. However, symmetric donor–acceptor (D–A) type usually produce spherical nanoaggregates, leading to tumor targeting but inferior retention. Rod‐like nanoaggregates desired extend their in tumors; however, this remains a challenge. In particular, dynamically changeable shapes that integrate merits of different morphologies seldomly reported. Therefore, self‐assembled organic smart shape tunability designed here using an asymmetric D–A TIBT. The photoluminescence quantum yield solids is up 52.24% for TIBT also exhibits ROS generation corresponding (TIBT‐NCs). Moreover, dynamic self‐assembly changing from nanospheres nanorods occurrs TIBT‐NCs, contributing enhancement 0.55 0.72. addition, can be observed both vitro vivo, conferring TIBT‐NCs strong Finally, efficient photodynamic therapy inhibit growth achieved inhibition rate 90%. This work demonstrates play significant roles forming thus showing great potential long‐acting cancer therapy.

Language: Английский

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Recent advances in near-infrared-II organic J-aggregates for bio-applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216379 - 216379

Published: Jan. 4, 2025

Language: Английский

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Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

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A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach introduce layer rationality the J-aggregate successful water-soluble JV-aggregate with bisbenzannulated silicon rhodamine scaffold (ESi5). resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, endogenous oxidative species. Notably, aggregates have high structure-dependent melting temperature ca. 330-335 K. In fact, heating/annealing process can exploited reduce disorder. are biocompatible broad potential in vivo fluorescence photoacoustic imaging more. While has applications, stable absorbers/emitters challenging access. Here, authors report J-aggregates bioimaging.

Language: Английский

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