Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 489, P. 215193 - 215193

Published: May 6, 2023

Language: Английский

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Engineering Near-Infrared Fluorescent Probes Based on Modulation of Molecular Excited States

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(1), P. 64 - 75

Published: Jan. 3, 2024

ConspectusFluorescent dyes have revolutionized the way we study life science and conduct medical diagnostics. Compared with visible wavelengths, near-infrared (NIR) fluorescence has gained significant attention due to its unique properties, such as deep tissue penetration, reduced autofluorescence, improved signal-to-noise ratios, making it highly desirable for a wide range of in vivo applications including noninvasive sensing, cancer research, drug delivery.In absorption light by fluorophore subsequent transition an excited state are critical steps. Once state, molecule may undergo various relaxation processes internal conversion, vibrational relaxation, radiative/nonradiative decay. These directly impact fluorophore's emission wavelength, brightness, photostability, other properties. Therefore, rational modulation molecular states is vital achieving effective sensing. However, NIR fluorophores small S0–S1 energy gap, governed gap law, exhibit much faster nonradiative deactivation pathway compared region. This fast process makes them more susceptible interference from aggregation behavior, environmental factors, so on. Thus, there often trade-off effect between tunable red-shift wavelength performance light-up imaging quantitative Overcoming these challenges requires careful engineering structures achieve desired balance extending bioimaging.In this Account, present our recent progress manipulating design fluorescent probes. Specifically, focus on novel building blocks, exploring photophysical mechanisms, regulating assembly behavior (to inhibit or amplify intramolecular motion aggregates), aiming resolve long-standing issues lighting-up mapping, First, introduce monochromophore-based "reliable ratiometric" strategy additional emission, enabling quantification hypoxia biomolecules. Second, demonstrate how reverse rotation driving energy, completely overturning charge transfer (ICT) fluorophores' quenching mode into mode. Third, discuss relationship chromophore relaxation. Through inhibiting amplifying motion, could well improve fidelity theranostic outcomes. Finally, explore future perspectives dynamic bioimaging. It hoped that Account provides deepening research guidance development high-performance probes physiological/pharmacological studies clinical applications.

Language: Английский

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Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 503, P. 215652 - 215652

Published: Jan. 9, 2024

Language: Английский

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Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

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Self‐Powered Sweat‐Responsive Structural Color Display

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 8, 2024

Abstract Despite the remarkable progress in development of sweat sensors, self‐powered sweat‐responsive sensing displays that detect electric signals with simultaneous and direct visualization is rarely demonstrated. Here, a structural color (SC) display enabled by ionomer‐doped block copolymer (BCP) photonic crystals (PCs) presented. The BCP PC developed employing cross‐linking single‐mobile ionomer (SMI) mobile anions anchored to immobile polycations 1‐D PC. hydrophobic SMI‐doped mechanically robust as well water temperature‐resistive, exhibiting concentration‐dependent full visible SCs. Moreover, periodically confined harvest triboelectric energy, giving rise high‐power density ≈0.774 Mw cm −2 . Cation‐sensitive SC variation observed PC, allowing containing various cations. A skin‐patchable demonstrated which kirigami‐patterned incorporated can withstand up 50% strain during exercise. Sweat from exercise visualized via measured using both ionic resistance changes signals. In addition, integration membrane into enables quantification sweat.

Language: Английский

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Design of a dual-function prodrug fluorescence probes for melanoma detection and anticancer drug release

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100500 - 100500

Published: Jan. 1, 2025

Language: Английский

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Rearranging fluorescence‐magneto spatiality for “win‐win” dual functions to enhance point‐of‐care diagnosis

Aggregate, Journal Year: 2023, Volume and Issue: 5(2)

Published: Nov. 10, 2023

Abstract Fluorescent‐magneto nanoemitters have gained considerable attention for their applications in mechanical controlling‐assisted optical signaling. However, the incompatibility between magnetic and fluorescent components often leads to functional limitations traditional magneto@fluorescence nanostructure. Herein, we introduce a new compact‐discrete spatial arrangement on “fluorescence@magneto” core–shell nanostructure consisting of close‐packed aggregation‐induced emission luminogen (AIEgen) core discrete shell. This structural design effectively eliminates interferences dual by facilitating AIEgens loading region reducing feeding amount through effective exposure units. Thereby, resulting magneto‐AIEgen nanoparticle (MANP) demonstrates “win‐win” performances: (i) high intensity contributed stacking‐enhanced photoluminescence reduced photons loss from meager shell; (ii) marked activity due magneto extraposition‐minimized shielding. Accordingly, functions‐retained MANP provides proof concept construction an immunochromatographic sensing platform, where it enables bright labeling after magnetically enriching separating procalcitonin lipoarabinomannan clinical human serum urine, respectively, diagnosis bacterial infections‐caused inflammation tuberculosis. study not only inspires rational magnetic‐fluorescent nanoemitter but also highlights promising potential magneto‐assisted point‐of‐care test biomedicine applications.

Language: Английский

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“Crossbreeding” NIR‐II flavchromene for PSMA‐positive prostate cancer detection and image‐guided surgery

Smart Molecules, Journal Year: 2024, Volume and Issue: 2(3)

Published: July 4, 2024

Abstract Prostate‐specific membrane antigen (PSMA) is known to be overexpressed in prostate cancer (PCa). The development of precise and rapid imaging technologies monitor PSMA crucial for early diagnosis therapy. Fluorescence the second near‐infrared window (NIR‐II) has emerged as a powerful tool real‐time tracking vivo visualization, offering high sensitivity resolution. However, there lack stable, bright easy‐to‐implement NIR‐II fluorescent probes targeting. Herein, we presented PSMA‐targeting probe FC‐PSMA based on π‐conjugated crossbreeding dyed strategy that affords stability, large extinction coefficient, good brightness. As demonstrated, displayed fluorescence quantum yield fetal bovine serum (FBS). Following intravenous injection FC‐PSMA, tumor‐to‐normal ratio intensity steadily increased over time, reaching peak at 48 h (tumor‐to‐leg = 12.16 ± 0.90). This advancement enables identification PC through imaging, facilitating high‐performance guidance resection surgery.

Language: Английский

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Tailoring the pK_a of Fluorescence Lifetime Imaging Probes to Visualize Aggrephagy and Resolve Its Microenvironmental Viscosity

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(35), P. 14160 - 14167

Published: Aug. 22, 2024

Aggrephagy describes lysosomal transport and degradation of protein aggregates via cellular macroautophagy, a key mechanism to prevent neurodegenerative diseases. Here, we develop dual-probe method visualize the aggrephagy process resolve its viscosity heterogeneity using fluorescence lifetime imaging (FLIM). The system consists (1) near-infrared targeting FLIM probe (Lyso-P1) that is derived from rhodamine scaffold with tailored p

Language: Английский

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