Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 137201 - 137201
Published: Dec. 1, 2024
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),
Language: Английский
Citations
19
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(8), P. 4405 - 4414
Published: Feb. 15, 2024
The photothermal lateral flow immunoassay (LFIA) is of great significance to suitable for on-site semiquantitative detection, which has the upper hand in further constructing detection methods low-concentration targets. Herein, we presented a doping engineering-powered nanoheterostructure with an enhanced performance strategy, employing bimetallic nanocuboid Pt3Sn (PSNCs) as proof concept. With help finite element simulation analysis, contrast direct temperature experiment, and evaluation conversion efficiency (η), distinguished enthusiastic feedback PSNCs proved. Based on steady bright black colorimetric superior performance, were employed construct ultrasensitive model LIFA detecting Salmonella typhimurium (S. typhimurium), achieved double-signal limit reached 103 cfu mL–1 (colorimetric mode) 102 (photothermal mode), 100 times higher than that traditional colloidal gold method. In addition, method was effective targets dairy samples only through simple dilution treatment, completed within 15 min. Meanwhile, this dual-signal LFIA demonstrated sensitive S. due excellent signal significant provides broad spectrum future foodborne pathogens.
Language: Английский
Citations
15
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 9, 2024
Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.
Language: Английский
Citations
11
Small, Journal Year: 2024, Volume and Issue: unknown
Published: June 7, 2024
Abstract Fluorescent lateral flow immunoassays (FLFIA) is a well‐established rapid detection technique for quantitative analysis. However, achieving accurate analysis of biomarkers at the pg mL −1 level using FLFIA still poses challenges. Herein, an ultrasensitive platform reported utilizing kiwi‐type magneto‐fluorescent silica nanohybrid (designated as MFS) that serves both target‐enrichment substrate and optical signal enhancement label. The spatially‐layered architecture comprises Fe 3 O 4 core, endocarp‐fibers like dendritic mesoporous silica, seed‐like quantum dots, kiwi‐flesh matrix. MFS demonstrates heightened fluorescence brightness, swift magnetic response, excellent size uniformity, dispersibility in water. Through liquid‐phase capturing fluorescence‐enhanced amplification, well magnetic‐enrichment sample amplification magnetic‐separation noise reduction, MFS‐based successfully applied to cardiac troponin I achieved limit 8.4 , tens times lower than those previously published fluorescent colorimetric immunoassays. This work offers insights into strategic design synergetic on LFIA underscores their prospects high‐sensitive on‐site diagnosis biomarkers.
Language: Английский
Citations
7
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(65), P. 8484 - 8496
Published: Jan. 1, 2024
Aggregation-induced emission (AIE)-based POC detection is important for diagnosis of diseases and assessment the effectiveness treatment programs. This review summarized advancement design application AIE-based biosensors.
Language: Английский
Citations
5
Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1323, P. 343091 - 343091
Published: Aug. 10, 2024
Language: Английский
Citations
5
Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 417, P. 136125 - 136125
Published: June 20, 2024
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Fluorescent lateral flow immunoassay (LFIA) is recognized as a leading quantitative point-of-care (POC) platform for precise clinical diagnostics. However, conventional fluorescent nanoprobes are hampered by low quantum yield (QY), which constrain the sensitivity of LFIA. Herein, we employed butterfly aggregation-induced emission luminogen (AIEgen) and developed fully inter-restricted assembly with polyphenyl polymer poly(maleicanhydride-styrene) (PMPS) to create highly homogeneous nanoparticles (ho-AIENPs) QY over 91%. Compared core-shell heterostructure (he-AIENPs), ho-AIENPs demonstrate structure AIEgens uniformly dispersed in PMPS matrix nanoparticles. The robust broad intermolecular interaction (e.g., π-π interactions) between effectively restricts molecular motion AIEgens, producing 30% increase than he-AIENPs. Ho-AIENPs exhibit 5-fold 80-fold improved compared traditional he-AIENP-based LFIAs AuNP-based colorimetric LFIAs. Owing excellent optical properties ho-AIENPs, ho-AIENP-based multiplex LFIAs, can simultaneously detect lung cancer biomarkers exceptionally high sensitivity. In contrast physical encapsulation strategies, strategy promising, versatile, efficient enhancing matrix-derived particles sensitizing immunoassays.
Language: Английский
Citations
0
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137601 - 137601
Published: March 1, 2025
Language: Английский
Citations
0
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 282, P. 117508 - 117508
Published: April 25, 2025
Language: Английский
Citations
0