Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 4086 - 4153

Published: Jan. 1, 2024

This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.

Language: Английский

---

Evolution of Copolymers of Epoxides and CO₂: Catalysts, Monomers, Architectures, and Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

The copolymerization of CO

Language: Английский

---

Recent Advances in Environment-Friendly Polyurethanes from Polyols Recovered from the Recycling and Renewable Resources: A Review

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1889 - 1889

Published: July 2, 2024

Polyurethane (PU) is among the most universal polymers and has been extensively applied in many fields, such as construction, machinery, furniture, clothing, textile, packaging biomedicine. Traditionally, main starting materials for PU, polyols deeply depend on petroleum stock. From perspective of recycling environmental friendliness, advanced PU synthesis, using diversified resources feedstocks, aims to develop versatile products with excellent properties achieve transformation from a fossil fuel-driven energy economy renewable sustainable ones. This review focuses recent development synthesis modification by extracting value-added monomers waste natural bio-based polymers, recycled polymers: polyethylene terephthalate (PET), polycarbonate (PC); biomaterials: vegetable oil, lignin, cashew nut shell liquid plant straw; biomacromolecules: polysaccharides protein. To design these polyurethane formulations, it essential understand structure-property relationships polyols. In word, this bottom-up path provides material approach printing packaging, well biomedical, building wearable electronics applications.

Language: Английский

---

Synthesis of Thermal-Resistant Polyester-Polycarbonate with Fully Rigid Structure from Biobased Isosorbide

Macromolecules, Journal Year: 2024, Volume and Issue: 57(13), P. 6284 - 6294

Published: June 25, 2024

Developing green and sustainable polymers is one of the effective ways to limit carbon emissions reduce dependence on petroleum resources. Therefore, polyester-polycarbonates based dioxide (CO2) have attracted extensive attention. However, with fully rigid structures are difficult prepare by traditional transesterification methods, which result in low glass transition temperatures insufficient mechanical properties. Here, a series (PCCITs) structure were prepared end hydroxyl shielding using dimethyl carbonate derived from CO2 biologically sourced isosorbide (IS), IS content 0–60 mol %. The ester bond polyester-polycarbonate was analyzed two-dimensional correlation spectroscopy (2DCOS). Due V-shaped fused ring IS, heat resistance copolyester significantly improved. temperature PCCITs ranges 64.2 131.1 °C, its distortion can reach up 120.1 °C. Furthermore, all copolyesters entirely amorphous exhibit good transparency (>88%) haze value (<4%). Notably, properties comparable those commercial heat-resistant polyethylene terephthalate glycol (PETG), tensile strength PCCT PCCIT60 increasing 43.5 57.8 MPa, elongation at break ranging 206.0 4.5%, impact 820.3 J m–1. Life cycle assessment evaluation showed that GWP PCCIT reduced, 41.5%, compared PETG. This work constructs IS-based through terminal method.

Language: Английский

---

Aqueous Developable and CO₂‐Sourced Chemical Amplification Photoresist with High Performance

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(32)

Published: May 6, 2024

Abstract Seeking high‐performance photoresists is an important item for semiconductor industry due to the continuous miniaturization and intelligentization of integrated circuits. Polymer resin containing carbonate group has many desirable properties, such as high transmittance, acid sensitivity chemical formulation, thus serving promising photoresist material. In this work, a series aqueous developable CO 2 ‐sourced polycarbonates (CO ‐PCs) were produced via alternating copolymerization epoxides bearing acid‐cleavable cyclic acetal groups in presence tetranuclear organoborane catalyst. The ‐PCs investigated amplification resists deep ultraviolet (DUV) lithography. Under catalysis photogenerated acid, (ketal) ‐PC hydrolysed into two equivalents hydroxyl groups, which change exposed area from hydrophobicity hydrophilicity, enabling be developed with water. Through normalized remaining thickness analysis, optimal ‐derived resist achieved remarkable 1.9 mJ/cm , contrast 7.9, favorable resolution (750 nm, half pitch), good etch resistance (38 % higher than poly( tert‐ butyl acrylate)). Such performances outperform commercial KrF ArF (i.e., polyhydroxystyrene‐derived polymethacrylate‐based resists), endows broad application prospects field DUV (KrF ArF) extreme (EUV) lithography nanomanufacturing.

Language: Английский

---

Impacts associated with the plastic polymers polycarbonate, polystyrene, polyvinyl chloride, and polybutadiene across their life cycle: A review

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32912 - e32912

Published: June 1, 2024

Polymers are the main building blocks of plastic, with annual global production volume fossil carbon-based polymers reaching over 457 million metric tons in 2019 and this figure is anticipated to triple by 2060. There potential for environmental harm adverse human health impacts associated its constituent chemicals therein, at all stages plastic life cycle, from extraction raw materials, manufacturing, consumption, through ultimate disposal waste management. While there have been considerable research policy efforts identifying mitigating problematic products such as single-use plastics hazardous plastics, national and/or international regulations phase out their use, often overlooked. In review, polymer dimension current knowledge on release, exposure discussed across including used additives commonly achieve properties needed applications which generally used. This review focuses polycarbonate, polystyrene, polyvinyl chloride, polybutadiene, four common made monomers, bisphenol, styrene, vinyl chloride 1,3-butadiene, respectively. Potential alternative polymers, chemicals, considered. Our findings emphasise need a whole system approach be undertaken effective regulation whereby assessed respect entire cycle.

Language: Английский

---

Organocatalytic Condensation Polymerization for Synthesis of High Performance Aliphatic Polycarbonate

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Aliphatic polycarbonate (APC) with long alkyl segments has received much attention for its biodegradability and biocompatibility. However, owing to low molecular weight, it usually exhibits poor mechanical properties limiting application. Here,a novel two‐step condensation polymerization procedure by using an organic catalyst ( t ‐BuP 2 ) synthesize high weight APC is presented. The introduction of branching hydrogen bonding in the would significantly improve thermal properties. a melt temperature ≈80 °C, tensile strength 17.7 ± 0.9 MPa, impressive elongation at break 1136 25%. This study provides facile high‐performance via polymerization.

Language: Английский

---

Redox-Responsive Cross-Linking of Polycarbonate Nanomedicines for Enhanced Stability and Controlled Drug Delivery

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Self-assembled polymeric micelles formed from amphiphilic block copolymers offer a promising strategy for enhanced drug delivery due to their biocompatibility and controlled release. However, challenges such as poor colloidal stability under diluted conditions degradation during storage circulation limit further applications. To address these issues, we developed straightforward method constructing cross-linked polycarbonate that enhance while allowing stimuli-responsive delivery. By utilizing disulfide-based cross-linking covalent conjugation of the anticancer drug, our approach maintains micelle integrity extremely high loading over extended periods well superior control triggered release compared non-cross-linked versions, demonstrating in complex biological environments improved efficacy, presenting novel platform stable polymer-drug conjugate nanocarriers, holding significant therapeutic potential targeted cancer treatment.

Language: Английский

---

Green and Efficient Synthesis of Biobased Polycarbonates with Tunable Performance via Functionalized Ionic Liquid Catalysts Enhanced by Cation–π Interactions

Industrial & Engineering Chemistry Research, Journal Year: 2024, Volume and Issue: 63(24), P. 10512 - 10523

Published: June 5, 2024

The utilization of biomass to produce plastic is one the key ways minimize negative impacts climate change and alleviate depletion petroleum resources. However, there still a lack bioderived polymers with properties comparable those commercial petroleum-based polymers. Isosorbide-based polycarbonate (PIC) most promising substitute for traditional petroleum-derived polycarbonate, but its application limited by low reactivity poor ductility isosorbide. In this study, we developed new strategy designing functionalized ionic liquid catalysts enhanced cation–π interactions, high performance isosorbide-based copolycarbonate was prepared. On hand, PIC weight-average molecular weight 126,000 g/mol synthesized using 1-benzyl-3-methylimidazolium acetate ([Bnmim][OAc]) as catalyst. This attributed formation stronger π–π interactions between benzyl group imidazolium cation, which promoted activation carbonyl groups overcame activity Furthermore, overcome brittleness PIC, introduction 1,10-decanediol into provided not only copolycarbonates an adequate elongation at break (121%), better than bisphenol A also wide range glass transition temperature (Tg 20–168 °C), expanding PIC. study provides avenue development excellent biobased polycarbonates catalysts.

Language: Английский

---

Emerging Trends in Microfluidic Biomaterials: From Functional Design to Applications

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 166 - 166

Published: May 8, 2025

The rapid development of microfluidics has driven innovations in material engineering, particularly through its ability to precisely manipulate fluids and cells at microscopic scales. Microfluidic biomaterials, a cutting-edge interdisciplinary field integrating microfluidic technology with biomaterials science, are revolutionizing biomedical research. This review focuses on the functional design fabrication organ-on-a-chip (OoAC) platforms via 3D bioprinting, explores applications drug delivery, cell culture, tissue evaluates potential systems advancing personalized healthcare. We systematically analyze evolution materials—from silicon glass polymers paper—and highlight advantages bioprinting over traditional methods. Currently, despite significant advances medicine, challenges scalability, stability, clinical translation remain. future will depend combining dynamic design, developing hybrid strategies that combine molds bio-printed structures, using artificial intelligence monitor delivery or response real time. believe collaborations between materials micromachining, medicine accelerate into therapies high-throughput screening tools.

Language: Английский

---