Talanta, Journal Year: 2024, Volume and Issue: 282, P. 126994 - 126994
Published: Oct. 4, 2024
Language: Английский
Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146
Published: Jan. 1, 2024
Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.
Language: Английский
Citations
78
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(22)
Published: March 29, 2024
The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, low response limits immunotherapy efficiency. Here, we report a ROS-responsive Fe
Language: Английский
Citations
15
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215842 - 215842
Published: April 15, 2024
Language: Английский
Citations
14
Smart Molecules, Journal Year: 2024, Volume and Issue: 2(3)
Published: Aug. 23, 2024
Abstract In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events disease diagnosis. The utilization versatile fluorescent probes in fluorescence imaging offers a powerful tool vivo biomarkers closely associated pathological conditions. However, the dynamic behavior leading to rapid clearance small molecule from regions interest severely compromises their potential imaging. Notably, self‐immobilizing that selectively recognize diseased tissues while improving retention enrichment enable accurate high‐fidelity this review, we aim summarize strategies employed recent advances performance precision using techniques. Lastly, discuss prospects challenges promote further development application more delicate probes.
Language: Английский
Citations
13
Aggregate, Journal Year: 2024, Volume and Issue: 5(3)
Published: Jan. 22, 2024
Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.
Language: Английский
Citations
12
Nano Letters, Journal Year: 2024, Volume and Issue: 24(20), P. 6131 - 6138
Published: May 10, 2024
Accurate intraoperative tumor delineation is critical to achieving successful surgical outcomes. However, conventional techniques typically suffer from poor specificity and low sensitivity are time-consuming, which greatly affects decision-making. Here, we report a cascade activatable near-infrared fluorescent (NIRF) probe IR780SS@CaP that can sequentially respond acidity elevated glutathione levels for accurate localization. Compared with nonactivatable single-factor probes, strategy minimize nonspecific activation false positive signals in complicated biological environment, affording superior tumor-to-normal tissue ratio facilitate the of abdominal metastases. Small metastatic lesions were less than 1 mm diameter be precisely identified by completely excised under NIRF imaging guidance. This study could benefit diagnosis image-guided surgery providing real-time information reliable decision support, thus reducing risk both recurrence complications improve patient
Language: Английский
Citations
9
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods precise imaging diagnosis. Intracellular hydrogen peroxide (H2O2) microenvironmental factors (e.g., viscosity polarity) are closely linked to various physiological pathological processes, making them potential biomarkers cancer. However, a triple-response theranostic probe therapy has not yet been achieved due lack of effective tools. Herein, we present mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable simultaneously monitoring H2O2, viscosity, polarity through dual NIR channels. The specifically detects H2O2 via emission (λem = 650 nm) shows high sensitivity viscosity/polarity deep channel ≈ 750 nm). Furthermore, only monitors mitochondrial polarity, fluctuations endogenous/exogenous levels but also distinguishes cells from normal multiple parameters. Additionally, VPH-5DF can be employed monitor alterations levels, as well during drug-induced pyroptosis living cells. After treatment with chemotherapy-induced oxidative damage mitochondria activated pathway, leading robust antitumor response, evidenced xenograft models. Thus, this prodrug offers new platform vivo diagnosis anticancer chemotherapy.
Language: Английский
Citations
1
Chemical Science, Journal Year: 2024, Volume and Issue: 15(19), P. 7324 - 7331
Published: Jan. 1, 2024
This work reports an acceptor engineering-boosted near-infrared fluorescent probe for high-fidelity imaging of tumour-associated β-galactosidase specifically in lysosomes and vivo .
Language: Английский
Citations
8
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(4), P. 1707 - 1716
Published: Jan. 19, 2024
Improving the retention of small-molecule-based therapeutic agents in tumors is crucial to achieve precise diagnosis and effective therapy cancer. Herein, we propose a β-galactosidase (β-Gal)-activated red light-induced RNA modification (GALIRM) strategy for prolonged tumor imaging. A β-Gal-activatable near-infrared (NIR) fluorescence (FL) positron emission tomography (PET) bimodal probe 68Ga-NOTA-FCG consists triaaza triacetic acid chelator NOTA 68Ga-labeling, β-Gal-activated photosensitizer CyGal, singlet oxygen (1O2)-susceptible furan group modification. Studies have demonstrated that emits an activated NIR FL signal upon cleavage by endogenous β-Gal overexpressed lysosomes, which combined with PET imaging 68Ga allowing highly sensitive ovarian Moreover, capability generating 1O2 under 690 nm illumination could be simultaneously unlocked, can trigger covalent cross-linking between nucleotides cytoplasmic RNAs. The formation probe-RNA conjugate effectively prevent exocytosis prolong tumors. We thus believe this GALIRM may provide entirely new insights into long-term efficient treatment.
Language: Английский
Citations
7
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(16), P. 6390 - 6397
Published: April 12, 2024
Although gastric cancer (GC) is one of the most frequent malignant tumors in digestive tract with high morbidity and mortality, it remains a diagnostic dilemma due to its reliance on invasive biopsy or insensitive assays. Herein, we report fluorescent reporter (FGCR) activatable near-infrared fluorescence (NIRF) signals renal-clearance efficiency for detection orthotopic GC murine model via real-time imaging remote urinalysis. In presence gastric-tumor-associated β-galactosidase (β-Gal), FGCR can be fluorescently activated vivo NIRF imaging. Relying (∼95% ID), rapidly excreted through kidneys urine ultrasensitive diameter down ∼2.1 mm assessing prognosis oxaliplatin-based chemotherapy. This study not only provides new approach noninvasive auxiliary diagnosis but also guidelines development probes diagnosis.
Language: Английский
Citations
6