Therapeutic Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 10
Published: Feb. 24, 2025
A
new
self-nanoemulsifying
drug
delivery
system
(SNEDDS)
was
developed
for
erlotinib
(Ert)
oral
delivery.
pseudo-ternary
phase
diagram
olive
oil,
Tween
80
and
polyethylene
glycol
(PEG)
600
mixtures,
firstly
constructed.
Based
on
the
data
about
Ert
solubility
cytotoxicity
of
these
components,
a
SNEDDS
composed
10%
20%
70%
(V/V)
selected
loading
(Ert-SNEDDS).
formed
31.2-nm
droplets
upon
dilution
in
water,
led
to
increment
oil
83.9
±
0.6
nm.
Ert-SNEDDS
represented
capacity
an
entrapment
efficiency
22.7
0.7
40.7
0.5%,
respectively.
release
from
monitored
both
mixture
phosphate
buffer
saline
0.5%
80,
artificial
gastric
fluid.
orally
administrated
rats,
plasma
level
over
time
measure
pharmacokinetic
parameters.
enhancement
bioavailability
changed
route
Ert.
showed
enhanced
toward
ASPC-1
PANC-1
cells,
half-maximal
inhibitory
concentration
values
were
obtained
compared
with
free
may
be
considered
as
alternative
EBioMedicine,
Journal Year:
2024,
Volume and Issue:
107, P. 105301 - 105301
Published: Aug. 23, 2024
Increasing
evidence
indicates
that
immunotherapy
is
hindered
by
a
hostile
tumor
microenvironment
(TME)
featured
with
deprivation
of
critical
nutrients
and
pooling
immunosuppressive
metabolites.
Tumor
cells
outcompete
immune
effector
for
essential
nutrients.
Meanwhile,
wide
range
cell-derived
toxic
metabolites
exerts
negative
impacts
on
anti-tumor
response,
diminishing
the
efficacy
immunotherapy.
Nanomedicine
excellent
targetability
offers
novel
approach
to
improving
cancer
via
metabolically
reprogramming
TME.
Herein,
we
review
recent
strategies
enhancing
immunotherapeutic
effects
through
rewiring
metabolism
nanomedicine.
Attention
drawn
immunometabolic
tactics
stromal
in
TME
Additionally,
discuss
future
directions
developing
metabolism-regulating
nanomedicine
precise
efficacious
Theranostics,
Journal Year:
2024,
Volume and Issue:
15(3), P. 993 - 1016
Published: Dec. 2, 2024
Immunotherapy
has
transformed
current
cancer
management,
and
it
achieved
significant
progress
over
last
decades.
However,
an
immunosuppressive
tumor
microenvironment
(TME)
diminishes
the
effectiveness
of
immunotherapy
by
suppressing
activity
immune
cells
facilitating
immune-evasion.
Adenosine
monophosphate-activated
protein
kinase
(AMPK),
a
key
modulator
cellular
energy
metabolism
homeostasis,
gained
growing
attention
in
anti-tumor
immunity.
Metformin
is
usually
considered
as
cornerstone
diabetes
its
role
activating
AMPK
pathway
also
been
extensively
explored
therapy
although
findings
on
remain
inconsistent.
nanomedicine
formulation
found
to
hold
potential
reprogramming
TME
through
immunometabolic
modulation
both
cells.
This
review
elaborates
foundation
via
metformin-based
nanomedicines,
offering
valuable
insights
for
next
generation
therapy.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Copper-based
nanoparticles
have
garnered
significant
interest
in
cancer
therapy
due
to
their
ability
induce
oxidative
stress
and
cuproptosis
cells.
However,
antitumor
effectiveness
is
constrained
by
the
dynamic
redox
balance
metabolic
shift
between
phosphorylation
glycolysis.
Here,
a
polydopamine-coated
copper-α-ketoglutaric
acid
(α-KG)
coordination
polymer
nanoparticle
(CKPP)
designed
for
combined
pyroptosis-cuproptosis
immunotherapy
amplifying
reactive
oxygen
species
(ROS)
production
regulating
cellular
metabolism.
The
intracellular
imbalance
achieved
through
synergistic
effects
of
α-KG-induced
mitochondrial
reprogramming,
photothermally
enhanced
superoxide
dismutase-like
activity
polydopamine,
glutathione
depletion
copper
ions.
multifaceted
modulation
results
substantial
increase
ROS
levels,
triggering
subsequent
pyroptosis
Furthermore,
α-KG
shifts
metabolism
from
glycolysis
phosphorylation,
thereby
enhancing
induced
combination
dyshomeostasis
inhibition
potent
enhancement
pyroptosis-cuproptosis-mediated
therapy.
In
murine
model
colorectal
cancer,
CKPP
exhibited
remarkable
anticancer
effect,
achieving
tumor
rate
96.3%
complete
eradication
two
out
five
cases.
Overall,
this
bio-engineered
metal-organic
nanocomposite
demonstrates
potential
treating
immunotherapy.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(35), P. 46090 - 46101
Published: Aug. 22, 2024
Epigallocatechin
gallate
(EGCG)-based
nanosystems
have
garnered
significant
attention
for
their
ability
to
alleviate
inflammation
due
excellent
anti-inflammatory
properties
and
enhanced
drug
delivery
capabilities.
However,
the
degradation
of
EGCG
in
strongly
acidic
environments
poses
a
challenge
potential
administration,
particularly
oral
formulations,
where
gastric
resistance
is
essential.
In
this
study,
we
develop
"disintegration
reorganization"
strategy
create
acid-resistant
antioxidant
nanoparticles
(EGA
NPs)
based
on
5-aminosalicylic
acid
(5-ASA)
mitigating
colitis
acute
kidney
injury.
At
pH,
ester
bond
breaks
down,
producing
two
building
blocks.
These,
together
with
5-ASA
formaldehyde,
form
oligomers
through
combination
phenol–aldehyde
condensation
Mannich
reaction.
The
resulting
self-assemble
into
EGA
NPs,
which
exhibit
stability
under
both
neutral
pH
conditions.
This
makes
them
suitable
allowing
withstand
harsh
conditions,
as
well
intravenous
injection.
Importantly,
these
retain
EGCG,
effectively
scavenging
reactive
oxygen
species
reducing
intracellular
oxidative
stress.
Additionally,
shows
carrier,
efficiently
loading
agent
curcumin
(Cur)
Cur@EGA
NPs.
vivo
studies
demonstrate
efficacy
alleviating
injury
following
respectively.
These
nanoparticulate
formulations
superior
reduction
compared
free
Cur
vivo.
Overall,
our
findings
introduce
novel
nanoplatform
treatment
inflammation.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Current
in
vitro
models
of
3D
tumor
spheroids
within
the
microenvironment
have
emerged
as
promising
tools
for
understanding
progression
and
potential
drug
responses.
However,
creating
with
functional
vasculature
remains
challenging
a
controlled
high‐throughput
manner.
Herein,
novel
open
3D‐microarray
platform
is
presented
spheroid‐endothelium
interaction
(ODSEI)
chip,
capable
arraying
more
than
1000
on
top
vasculature,
compartmentalized
single
spheroid‐level
analysis
resistance,
allows
extraction
specific
further
analysis.
As
proof
concept,
crosstalk
between
breast
cancer
monitored,
validating
roles
endothelial
cells
acquired
tamoxifen
resistance.
Cancer
exhibited
reduced
sensitivity
to
presence
vasculature.
Further
through
single‐cell
RNA
sequencing
extracted
protein
arrays
elucidated
gene
expression
profiles
cytokines
associated
particularly
involving
TNF‐α
pathway
via
NF‐κB
mTOR
signaling.
By
targeting
highly
expressed
(IL‐8,
TIMP1)
identified,
resistance
spheroid
can
be
effectively
reversed.
In
summary,
ODSEI
chip
study
various
contexts,
leading
improved
insights
into
biology
therapeutic
strategies.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Non‐small
cell
lung
cancer
(NSCLC)
has
a
strikingly
high
incidence
rate
globally.
Although
immunotherapy
brings
great
breakthrough
in
its
clinical
treatment
of
NSCLC,
significant
challenges
still
need
to
be
overcome.
The
development
novel
multi‐functional
nanomedicines
the
realm
tumor
offers
promising
opportunities
for
NSCLC
patients,
as
exhibit
advantages,
including
specific
targeting
cells,
improved
drug
bioavailability,
reduced
systemic
toxicity,
and
overcoming
immune
resistance.
In
this
review,
core
features
current
status
strategies
checkpoint
blockade,
antibody–drug
conjugates,
engagers,
adoptive
vaccines,
are
surveyed.
Particular
emphasis
is
placed
on
recent
that
boost
these
strategies.
Nanomedicine
can
provide
perspectives
immunotherapy.
