Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(44), P. 9503 - 9507
Published: Oct. 28, 2024
Herein,
we
describe
a
dual
catalytic
strategy
that
employs
dihydroquinazolinones,
derived
from
ketone
analogs,
as
versatile
intermediates
for
acylation
via
α
C–C
cleavage
with
2-pyridyl
esters,
facilitating
the
efficient
synthesis
of
variety
ketones.
The
reaction
accommodates
wide
range
ketones
and
carboxylic
acids,
showing
tolerance
to
various
functional
groups.
versatility
this
synthetic
technique
is
further
highlighted
through
its
application
in
late-stage
modification
pharmaceuticals
biologically
active
natural
products.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
α
−Sulfide
disulfides
represent
valuable
motifs
in
organic
and
pharmaceutical
chemistry.
However,
the
limited
availability
of
synthetic
approaches
for
−sulfide
has
impeded
progress
this
field.
In
study,
a
photocatalytic
approach
to
synthesizing
modifiable
is
presented
using
accessible
sulfides
bilateral
disulfurating
reagent.
The
reaction
proceeds
under
mild
conditions
demonstrates
broad
substrate
compatibility,
accommodating
both
aromatic
aliphatic
sulfides.
Moreover,
synthesized
display
robust
reactivity
subsequent
transformations
with
different
electrophiles.
Notably,
protocol
can
also
be
applied
modification
polymer
matrices.
Bioassays
further
reveal
that
certain
target
compounds
exhibit
significant
antibacterial
activity
against
plant
pathogens,
such
as
Xanthomonas
oryzae
pv.
(
Xoo
),
pathovar
oryzicola
Xoc
Dickeya
zeae
D.
).
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(27), P. 5561 - 5568
Published: Jan. 1, 2024
An
organo-photoredox
catalyzed
defluorinative
alkylation
of
ketone-derived
dihydroquinazolinones
with
α-trifluoromethyl
alkenes
is
described,
providing
a
facile
access
to
diverse
set
gem
-difluoroalkenes.
Carbon Energy,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 23, 2024
Abstract
Investigating
the
activation
of
persulfate
process
through
heterogeneous
carbonaceous
catalysts
to
expedite
reduction
uranyl
ions
(U(VI))
is
imperative.
The
primary
hurdle
involves
understanding
transfer
and
distribution
photogenerated
carriers
during
in
this
intricate
system
deciphering
role
activated
groups
promoting
efficiency.
In
study,
we
strategically
regulate
structure
polymeric
carbon
nitride
promote
N‐doped
state,
thereby
facilitating
delocalization
electron
enrichment.
resulting
active
sites
effectively
activate
peroxyl
disulfate
(PDS),
generating
radicals
that
selective
U(VI).
This
strategic
approach
mitigates
inherent
disadvantage
short
half‐life
free
persulfate‐based
advanced
oxidation
processes.
As
a
consequence
our
endeavors
with
simultaneous
presence
PDS
hydrogen
peroxide,
achieve
an
exceptional
photoreduction
efficiency
100%
within
remarkably
period
20
min.
breakthrough
presents
high‐efficiency
application
significant
potential
for
addressing
pollution
associated
uranyl‐containing
wastewater.
Our
findings
not
only
contribute
fundamental
AOPs
but
also
offer
practical
solution
implications
environmental
remediation.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(48)
Published: June 26, 2024
We
disclose
herein
a
novel
and
general
radical
approach
to
alkylthiopurines,
encompassing
4
types
of
thiopurines,
as
well
their
corresponding
ribosides.
This
strategy
is
achieved
through
visible
light-mediated
late-stage
functionalization
the
sulfur
atoms
mercaptopurines.
The
in
situ-generated
disulfide
was
proposed
pivotal
neutral
intermediate
for
this
transformation.
present
photo-mediated
homolytic
C-S
bond
formation
preparation
alkylthiopurines
alkylthiopurine
nucleosides.
Despite
presence
reactive
sites
Minisci
reaction,
chemoselective
S-alkylation
remained
predominant
pathway.
method
allows
introduction
broad
spectrum
alkyl
groups
onto
atom
unprotective
mercaptopurine
derivatives,
2-,
6-,
8-mercaptopurine
rings.
Organoborons
serve
efficient
eco-friendly
alkylating
reagents,
providing
advantages
terms
readily
availability,
stability,
reduced
toxicity.
Further
derivatization
thioetherified
nucleosides,
together
with
anti-tumor
assays,
led
discovery
potent
agents
an
IC
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(31), P. 6277 - 6281
Published: Jan. 1, 2024
A
method
for
the
synthesis
of
thiocarbamates
catalyzed
by
Na
2
CO
3
from
isocyanates
and
thiols
was
developed,
possible
mechanism
proposed.
This
has
advantages
high
yield,
good
tolerance,
atom
economy
mild
conditions.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(42)
Published: July 24, 2024
Abstract
The
homolysis
of
chemical
bonds
represents
one
the
most
fundamental
reactivities
excited
molecules.
Historically,
it
has
been
exploited
to
generate
radicals
under
ultraviolet
(UV)
light
irradiation.
However,
unlike
contemporary
radical‐generating
mechanisms,
direct
excitation
homolyze
and
produce
aliphatic
carbon‐centered
visible
remains
rare,
especially
in
metallaphotoredox
cross
couplings.
Herein,
we
present
our
design
dihydropyrimidoquinolinone
(DHPQ)
reagents
derived
from
ketones,
which
can
undergo
formal
deacylation
homolytic
C−C
bond
cleavage
release
alkyl
without
external
photocatalysts.
Spectroscopic
computational
analysis
reveal
unique
optical
structural
features
DHPQs,
rationalizing
their
faster
kinetics
radical
generation
than
a
structurally
similar
but
visible‐light
transparent
precursor.
Such
capability
allows
DHPQ
facilitate
wide
range
Ni‐metallaphotoredox
couplings
with
aryl,
alkynyl
acyl
halides.
Other
catalytic
non‐catalyzed
alkylative
transformations
DHPQs
are
also
feasible
various
acceptors.
We
believe
this
work
would
be
broad
interest,
aiding
synthetic
planning
simplified
operation
expanding
reach
photocatalyst‐free
approaches
cutting‐edge
research.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(62)
Published: Aug. 22, 2024
Herein,
we
report
a
facile
and
efficient
deuteration
degree
controllable
method
for
the
preparation
of
aryl
deuteromethyl
ethers
through
dual
photoredox
thiol
catalysis
using
phenols
as
starting
materials
inexpensive
D
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(39)
Published: Oct. 1, 2024
Abstract
Herein
the
one‐pot
thioesterification
and
hydrothiolation
of
α
,
β
‐unsaturated
esters
with
aliphatic
thiols
was
reported
at
room
temperature.
The
mechanism
indirectly
revealed
which
thioester
intermediate.
advantages
this
method
included
transition‐metal‐free,
mild
conditions,
broad
substrate
scope
good
functional
group
tolerance.
On
other
hand,
temperature
also
developed.
