Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Key intracellular in situ synthesis processes, including the of near-infrared fluorescent dyes, oxidative cross-linking, polymerization, and bioorthogonal reactions, as well their biomedical applications were summarized.
Language: Английский
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 8048 - 8061
Published: Jan. 1, 2024
Photothermal therapy (PTT) is an important non-invasive cancer treatment method.
Language: Английский
Citations
11
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Abstract Single‐atom nanozymes (SANs) are promising enzyme‐active catalysts due to their maximum atomic utilization. However, it is still a challenge precisely regulate the single‐atom structure, especially in multimetallic MOFs. Based on Cu‐N 4 structure of Zn Cu 1 , cascade competition strategy mediated by buffer (polydopamine) proposed for first time, which induces one‐step nonthermal reaction remove inactive site and adjust coordination environment. Experimental results theoretical calculations show that nanozyme with 2 O (Cu‐N/O) breaks strong steric restriction, exposed active can better adsorb H making have peroxidase‐like activity. Compared traditional bimetallic (Cu ) monometallic (Cu‐MoF) nanozymes, has stronger catalytic activity photothermal properties, as well good photocatalytic extremely stability. It successfully applied Lateral flow immunoassay achieve three‐mode ultrasensitive detection Escherichia coli O157:H7, test strips after subjected broad‐spectrum sterilization treatment.
Language: Английский
Citations
1
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(20), P. 4785 - 4808
Published: Jan. 1, 2024
This review focuses on the versatile applications of near-infrared (NIR)-responsive smart carriers in biomedical applications, particularly drug delivery and photothermal chemotherapy.
Language: Английский
Citations
5
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10786 - 10817
Published: Jan. 1, 2024
The review highlights the potential of RGD-conjugated AuNPs in cancer diagnosis and treatment, including breast cancer. It emphasizes need for further research to fully realize this technology’s inspire future investigations.
Language: Английский
Citations
5
Nano Letters, Journal Year: 2024, Volume and Issue: 24(50), P. 16132 - 16142
Published: Dec. 6, 2024
Immunotherapy is revolutionizing oncology, but its therapeutic efficiency still limited by the off-target toxicities and poor antitumor immune responses. By integrating drug-loaded nanoparticles (DMnSH) with unique metabolic traits of Veillonella parvula (Vei), a probiotic–nanomedicine conjugate Vei@DMnSH biohybrid elaborately designed for enhanced cancer chemo-immunotherapy. Specifically, can accumulate in hypoxic tumor sites simultaneously consume lactate cysteine to reverse lactate-associated immunosuppression impede biosynthesis GSH. In addition, DMnSH will rapidly deplete intracellular GSH disassemble release DOX Mn2+. Accompanied two-pronged depletion, Mn2+-mediated Fenton-like reaction effectively generate oxidative hydroxyl radicals induce heavy redox imbalance. Combined effect DOX, robust immunogenic cell death provoked subsequently activates adaptive immunity suppression rate over 82%, synergistically enhancing outcomes
Language: Английский
Citations
5
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Chemical and biological orthogonal reactions involving click chemistry continue to be a prominent area of interest in biomedical research. Click chemistry, as linking reaction, effectively connects diverse small molecular units generate large molecules with specific structures functions. This reaction finds widespread application modifying the surfaces nanoparticles. Traditional organic often encounters challenges synthesizing carbon heteroatom bonds, accompanied by numerous side reactions. Moreover, limited availability chemical groups on nanoparticle significantly restricts their modification through conventional However, development has triumphed over these hurdles, ensuring that complex no longer impede surface These high-performance possess characteristics are absent current environment, including high selectivity, rapid rates, excellent biocompatibility. The utilization greatly propelled nanoparticles realm tumor treatment. Increasingly, tumor-targeting being conjugated Furthermore, bioorthogonal derived from emerging trending topic contemporary trends becoming increasingly apparent recent reports, garnering greater attention within field nanomedicine engineering. In this review, we elucidate potential for modifications nanomaterials using particular focus its role targeted cancer Additionally, summarize existing future opportunities domain.
Language: Английский
Citations
0
Journal of Extracellular Vesicles, Journal Year: 2025, Volume and Issue: 14(2)
Published: Feb. 1, 2025
ABSTRACT Acetaminophen (APAP) overdose can cause severe liver injury and life‐threatening conditions that may lead to multiple organ failure without proper treatment. N‐acetylcysteine (NAC) is the accepted prescribed treatment for detoxification in cases of APAP overdose. Nonetheless, acute (ALF), particularly when ingestion substantial, NAC not fully restore function. administration ALF has limitations potential adverse effects, including nausea, vomiting, diarrhoea, flatus, gastroesophageal reflux, anaphylactoid reactions. Mesenchymal stromal cell (MSC)‐based therapies using paracrine activity show promise treating ALF, with preclinical studies demonstrating improvement. Recently, MSC‐derived extracellular vesicles (EVs) have emerged as a new therapeutic option injury. EVs contain various cargos depending on origin, participate physiological processes, respond abnormalities. However, most lack distinct orientation upon entering body, resulting targeting specificity. Therefore, enhancing precision natural EV delivery systems urgently needed. Thus, we developed an advanced technique deliver modified within body. Our strategy aims employ bioorthogonal click chemistry attach molecule surface small (sEVs), creating exogenous chimeric antigen receptor‐modified sEVs (CAR‐sEVs) First, engineered azido‐modified (N 3 ‐sEVs) through metabolic glycoengineering by MSCs azide‐containing monosaccharide N‐azidoacetyl‐mannosamine (Ac4ManNAz). Next, conjugated N ‐sEVs dibenzocyclooctyne (DBCO)‐tagged single‐chain variable fragment (DBCO‐scFv) targets asialoglycoprotein receptor (ASGR1), thus producing CAR‐sEVs precise targeting. The efficacy CAR‐sEV therapy models ASGR1 was validated. reduced serum enzymes, mitigated damage, promoted hepatocyte proliferation APAP‐induced Overall, exhibited enhanced specificity ameliorating injury, highlighting significant advancements achievable cell‐free targeted therapy.
Language: Английский
Citations
0
Exploration, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
ABSTRACT Gold nanomaterials have been used in the diagnosis and treatment of different tumors due to their unique physical chemical properties. Among them, gold nanoparticles with stimuli‐responsive aggregation functions attracted extensive attention because they can meet needs tumor at stages through structural changes. However, how effectively modify achieve transformation for specific stimuli, role corresponding improving effect still lack systematic summary. In this review, we comprehensively summarized current strategies inducing its advances treatment.
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This feature article provides a detailed overview of the synthesis, properties and applications sydnonimines, fascinating compounds from mesoionic familly.
Language: Английский
Citations
0
Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(2)
Published: March 13, 2025
Language: Английский
Citations
0