Near-infrared
(NIR)
persistent
luminescence
(PersL)
materials
have
unique
optical
properties
with
promising
applications
in
bioimaging
and
anticounterfeiting.
However,
their
development
is
currently
hindered
by
poor
red-light-exciting
ability.
In
this
study,
CaTiO3:Cr0.001,Y0.02
(CTCY)
was
synthesized
650
nm-excited
772
nm
NIR
PersL.
The
Y3+
doping
the
Ca2+
lattice
plays
a
key
role
PersL
property.
A
charge
compensation
mechanism
proposed,
which
Cr3+
Ti4+
stabilized
Y3+-doping
while
oxygen
vacancies
were
generated
to
store
excitation
energy
at
same
time.
thermal
ionization
might
elucidate
red-light-excited
of
CTCY,
benefits
from
perovskite
structure
CaTiO3.
CTCY
has
120
times
more
intense
than
Zn3Ga2Ge2O10:Cr.
Its
potential
anticounterfeiting
demonstrated
using
visible/NIR
dual-channel
flower
painting
CTCY-labeled
bone
screw
for
situ
reactivable
imaging
red
light
illumination
instead
X-ray,
respectively.
This
study
not
only
provides
new
material
but
also
will
add
our
understanding
developing
other
red-light-
or
even
NIR-activable
perovskite-like
structures.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 8, 2024
Abstract
Activatable
afterglow
luminescence
nanoprobes
enabling
switched
“off-on”
signals
in
response
to
biomarkers
have
recently
emerged
achieve
reduced
unspecific
and
improved
imaging
fidelity.
However,
such
always
use
a
biomarker-interrupted
energy
transfer
obtain
an
activatable
signal,
which
necessitates
strict
distance
requisition
between
donor
acceptor
moiety
(<10
nm)
hence
induces
low
efficiency
non-feasibility.
Herein,
we
report
organic
upconversion
cocktail
nanoparticles
(ALCNs)
that
instead
utilize
acidity-manipulated
singlet
oxygen
(
1
O
2
)
with
enlarged
thus
possess
more
flexibility
signal.
After
vitro
validation
of
acidity-activated
luminescence,
ALCNs
vivo
4T1-xenograft
subcutaneous
tumors
female
mice
orthotopic
liver
male
high
signal-to-noise
ratio
(SNR).
As
representative
targeting
trial,
Bio-ALCNs
biotin
modification
prove
the
enhanced
ability,
sensitivity,
specificity
for
pulmonary
metastasis
tumor
via
systemic
administration
mice,
also
implies
potential
broad
utility
diverse
design
flexibility.
Therefore,
this
study
provides
innovative
general
approach
better
performance
than
fluorescence
imaging.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Afterglow
luminescence
provides
ultrasensitive
optical
detection
by
minimizing
tissue
autofluorescence
and
increasing
the
signal-to-noise
ratio.
However,
due
to
lack
of
suitable
unimolecular
afterglow
scaffolds,
current
agents
are
nanocomposites
containing
multiple
components
with
limited
performance
have
rarely
been
applied
for
cancer
theranostics.
Herein,
we
report
synthesis
a
series
oxathiine-containing
donor-acceptor
block
semiconducting
polymers
(PDCDs)
observation
their
high
photoreactivity
strong
near-infrared
(NIR)
luminescence.
We
reveal
that
PDCDs
absorb
NIR
light
undergo
photodynamic
process
generate
singlet
oxygen
(1O2),
which
intramolecularly
transfers
efficiently
reacts
oxathiine
form
intermediates
low
Gibbs
free
energy
changes
required
this
photoreaction.
Following
intramolecular
transfer
from
donor
acceptor
block,
emission
is
produced
PDCDs.
Owing
efficient
cascade
photochemical
process,
PDCD-based
nanoparticles
achieve
higher
brightness
longer
compared
most
reported
agents,
even
after
ultrashort
photoirradiation
only
3
s.
Furthermore,
within
PDCD
can
be
inhibited
bioconjugation
quencher-linked
peptide.
This
allows
construction
cancer-activatable
theranostic
probe
(CATP)
switches
on
signal
function
in
presence
cancer-overexpressed
enzyme.
Thereby,
CATP
represents
first
phototheranostic
permits
cancer-specific
therapy
under
preclinical
settings.
In
summary,
study
molecular
guideline
develop
probes
photoreactive
polymers.
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
The
advancements
in
early
stratification
and
timely
evaluation
of
therapeutic
effects
have
revolutionized
the
ability
to
assess
curative
outcomes
promptly.
separation
between
diagnosis/treatment
assessment
treatment
response,
along
with
delays
evaluating
therapy
efficacy,
are
significant
contributors
failures.
Traditional
approaches
for
face
challenges
posed
by
tumor
heterogeneity
resistance,
making
it
challenging
determine
effectiveness
a
given
regimen
at
an
stage
clinical
practice.
However,
molecular
imaging
using
activatable
probes
has
overcome
these
obstacles
transformed
field
shifting
focus
towards
developing
functional
visualizing
tumors
as
well
enabling
or
effects.
In
this
article,
we
emphasize
importance
diverse
provide
insights
into
various
therapies’
Finally,
discuss
faced
propose
future
research
directions.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
An
overview
of
the
recent
advances
in
reactive
oxygen
species-mediated
organic
long-persistent
luminophores,
including
their
history,
working
mechanisms,
design
strategies,
and
biomedical
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(45), P. 61739 - 61750
Published: Oct. 30, 2024
Type
I
photodynamic
therapy
(PDT)
exhibits
outstanding
therapeutic
effects
in
hypoxic
environments
tumors,
but
the
design
of
type
photosensitizers
(PSs),
especially
those
with
simple
structures
dramatic
properties,
remains
a
challenge.
Herein,
we
report
strategy
for
developing
PSs
one
molecule
afterglow
luminescence.
As
proof
concept,
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
(BODIPY)
PS
(BIP)
bearing
water-soluble
poly(ethylene
glycol)
(mPEG550)
chains
is
synthesized,
and
BIP
can
self-assemble
into
nanoparticles
(BIPNs).
Interestingly,
BIPNs
exhibit
an
O2•--triggered
luminescence,
which
scarce,
BODIPY
derivatives.
demonstrate
dominant
PDT
at
ultralow
dose
under
both
normoxic
environments,
significantly
inhibit
tumor
growth
irradiation.
This
work
highlights
high-performance
luminescence
excellent
effects,
underscoring
significant
potential
versatile
clinical
theranostics.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Organic
afterglow
luminescence
can
emit
light
long
after
the
cessation
of
irradiation,
enabling
autofluorescence-free
in
vivo
imaging
with
high
signal-to-background
ratios
(SBRs).
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(13)
Published: March 26, 2025
Cardiovascular
diseases,
including
stroke
driven
by
atherosclerosis,
remain
a
leading
global
health
concern.
Current
diagnostic
imaging
modalities
such
as
magnetic
resonance
fail
to
characterize
oxidative
stress
within
atherosclerotic
plaques.
Here,
we
introduce
difuranfluoreno-dithiophen–based
polymers
designed
for
afterglow
imaging,
offering
ultrabright
luminescence,
ultralow-power
excitation
(0.087
milliwatts
per
square
centimeter),
and
ultrashort
acquisition
times
(0.01
seconds).
Through
molecular
engineering
strategy,
have
optimized
enhanced
reactive
oxygen
species
(ROS)
generation
capability,
ROS
capturing
fluorescence
quantum
yield,
resulting
in
an
increase
intensity
(~130-fold)
compared
commonly
used
2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene
polymer
(MEHPPV).
Additionally,
developed
ratiometric
nanoparticles
doped
with
stress–responsive
molecules,
enabling
of
markers
plaque.
This
approach
provides
tool
cardiovascular
diagnostics,
which
is
conducive
the
auxiliary
diagnosis
risk
stratification
atherosclerosis.
