Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 22, 2024

Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Language: Английский

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Sulfur-Vacancy-Engineered Two-Dimensional Cu@SnS_2–x Nanosheets Constructed via Heterovalent Substitution for High-Efficiency Piezocatalytic Tumor Therapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21496 - 21508

Published: July 29, 2024

Ultrasound (US)-mediated piezocatalytic tumor therapy has attracted much attention due to its notable tissue-penetration capabilities, noninvasiveness, and low oxygen dependency. Nevertheless, the efficiency of is limited an inadequate piezoelectric response, separation electron–hole (e––h+) pairs, complex microenvironment (TME). Herein, ultrathin two-dimensional (2D) sulfur-vacancy-engineered (Sv-engineered) Cu@SnS2–x nanosheet (NS) with enhanced effect was constructed via heterovalent substitution strategy Sn4+ by Cu2+. The introduction Cu2+ ion not only causes changes in crystal structure increase polarization but also generates rich Sv decrease band gap from 2.16 1.62 eV inhibit e––h+ pairs recombination, collectively leading highly efficient generation reactive species under US irradiation. Moreover, shows US-enhanced TME-responsive Fenton-like catalytic activity glutathione depletion ability, further aggravating oxidative stress. Both vitro vivo results prove that Sv-engineered NSs can significantly kill cells achieve high-efficiency a biocompatible manner. Overall, this study provides new avenue for sonocatalytic broadens application 2D materials.

Language: Английский

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Defect Engineering of Biodegradable Sulfide Nanocage Sonozyme Systems Enables Robust Immunotherapy Against Metastatic Cancers

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract It is important but challenging to innovate inorganic sonosensitizers with controlled biodegradability and enhanced sonodynamic chemodynamic activities harness remodel the immunosuppressive tumor microenvironment (TME) for awakening robust immune responses against metastatic cancers. Herein rational design defect engineering strategy of a pH‐responsive biodegradable sonozyme system in sulfide nanocages augmented cancer immunotherapy reported. A series highly defective Co 9 S 8‐x elevated sulfur‐vacancy (V ) levels are fabricated systematically explore V ‐dependent properties by regulating weight ratio sulfur cobalt source. The bandgap substantially reduced from 2.06 1.54 eV, atomic 2+ 3+ increased 1.53 1.97. Therefore, sonodynamic, chemodynamic, antitumor dramatically system. slow degradation slightly acid TME size targeting infiltration, while exerting slight influence on performance. As result, satisfactory therapeutic effects eradication primary, distant, tumors can be achieved. This work highlights potential strategies combating

Language: Английский

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Engineering Polyheptazine and Polytriazine Imides for Photocatalysis

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(49)

Published: Aug. 27, 2024

Abstract As organic semiconductor materials gain increasing prominence in the realm of photocatalysis, two carbon‐nitrogen materials, poly (heptazine imide) (PHI) and (triazine (PTI), have garnered extensive attention applications owing to their unique structure properties. This review elaborates on distinctive physical chemical features PHI PTI, emphasizing formation mechanisms ensuing Furthermore, it elucidates intricate correlation between energy band structures various photocatalytic reactions. Additionally, outlines primary synthetic strategies for constructing along with characterization techniques identification. It also summarizes enhancing performance whose advantages are discussed. Finally, highlights promising prospects challenges PTI as photocatalysts.

Language: Английский

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Nanocomposites Based on Layered Double Hydroxides Loaded with Curcumin and Carbon Nitride Quantum Dots for Combined Chemotherapy and Chemodynamic Therapy of Tumors

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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C3N4 nanosheet: sonopiezoelectric effect to boost NO therapy

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 120330 - 120330

Published: April 1, 2025

Language: Английский

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Dual‐Defect Regulated G‐C₃N₄ for Piezoelectric Catalytic Tumor Therapy with Enhanced Efficacy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Piezoelectric catalysis for tumor treatment is an emerging method generating reactive oxygen species (ROS). However, the development and optimization of piezoelectric catalytic nanomaterials remain major challenge. Herein, by regulating internal surface defects graphene phase carbon nitride (defect‐engineered g‐C 3 N 4 ), its piezoelectricity sonocatalytic performance enhanced, thus achieving efficient treatment. By reducing bulk defects, charges excited ultrasound (US) within defect‐engineered can migrate more rapidly to material surface, thereby enhancing their participation in redox reactions. Increasing not only introduce active sites on but also enhance asymmetry structure, resulting excellent properties. This nanosheet effectively generate ROS cells induce cell apoptosis under US stimulation. work introduces a expands potential application materials

Language: Английский

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Editing Benzotrithiophene-Based Covalent Organic Frameworks for Developing New Sonosensitizers

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent therapeutic effect. Particularly, because enhanced D-A effect that promotes charge separation transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight great potential elaborate editing configurations as suitable candidates advanced sonosensitizers.

Language: Английский

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2D/2D ultra-thin porous carbon nitride/ZnIn₂S₄ heterojunctions for photocatalytic hydrogen evolution and methyl orange degradation

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Effective charge separation and sufficiently exposed active sites are both critical limiting factors for solar-driven photocatalytic technology.

Language: Английский

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Enhanced Sonodynamic Cancer Therapy through Boosting Reactive Oxygen Species and Depleting Glutathione

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

The complex tumor microenvironment (TME) affects reactive oxygen species (ROS)-based therapies; breaking the limitations of TME to enhance effectiveness sonodynamic therapy (SDT) is full great challenges. Herein, iron atomically dispersed nanoparticles (Fe-N-C) were first reported as sonosensitizers with highly efficient ROS generation by overcoming limitations. Its peroxidase and catalase-like activities catalyze H2O2 produce toxic ·OH in situ O2, respectively, then O2 molecules adsorbed at Fe active sites obviously lower energy barrier for formation. Meanwhile, its glutathione-oxidase-like activity can rapidly consume glutathione (GSH) induce cell apoptosis ferroptosis. Density functional theory calculation results elucidate possible mechanism generation: are activated receiving sonoelectrons generate ·O2-, which further reacts H2O OH-. Then OH- oxidized sonoholes form ·OH. Fe-N-C displays a superior specificity SDT.

Language: Английский

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