Materials,
Journal Year:
2022,
Volume and Issue:
15(24), P. 8928 - 8928
Published: Dec. 14, 2022
Hydrogels
have
been
used
as
scaffolds
for
biomineralization
in
tissue
engineering
and
regenerative
medicine
the
repair
treatment
of
many
types.
In
present
work,
we
studied
an
amino
acid-based
material
that
is
attached
to
protecting
groups
self-assembles
into
biocompatible
stable
nanostructures
are
suitable
applications.
Specifically,
doubly
protected
aspartic
residue
(Asp)
with
fluorenyl
methoxycarbonyl
(Fmoc)
shown
lead
formation
well-ordered
fibrous
structures.
Many
acids
small
peptides
which
modified
display
relatively
fast
self-assembly
exhibit
remarkable
physicochemical
properties
leading
three-dimensional
(3D)
networks,
trapping
solvent
molecules,
forming
hydrogels.
this
study,
self-assembling
structures
targeted
toward
calcium
binding
act
nucleation
points
available
phosphate
groups.
The
cell
viability,
proliferation,
osteogenic
differentiation
pre-osteoblastic
cells
cultured
on
formed
hydrogel
under
various
conditions
demonstrate
CaCl2
CaCl2-Na2HPO4
solutions
ion
onto
hydrogels
enrichment
groups,
respectively,
rendering
these
mechanically
osteoinductive
bone
engineering.
Journal of Biological Engineering,
Journal Year:
2023,
Volume and Issue:
17(1)
Published: March 20, 2023
Abstract
As
an
emerging
science,
tissue
engineering
and
regenerative
medicine
focus
on
developing
materials
to
replace,
restore
or
improve
organs
tissues
enhancing
the
cellular
capacity
proliferate,
migrate
differentiate
into
different
cell
types
specific
tissues.
Renewable
resources
have
been
used
develop
new
materials,
resulting
in
attempts
produce
various
environmentally
friendly
biomaterials.
Poly
(lactic
acid)
(PLA)
is
a
biopolymer
known
be
biodegradable
it
produced
from
fermentation
of
carbohydrates.
PLA
can
combined
with
other
polymers
biomaterials
suitable
physicochemical
properties
for
applications.
Here,
advances
modified
as
are
discussed
light
its
drawbacks,
such
biological
inertness,
low
adhesion,
degradation
rate,
efforts
conducted
address
these
challenges
toward
design
enhanced
alternative
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
487, P. 150403 - 150403
Published: March 16, 2024
Hydrogels
have
emerged
in
various
biomedical
applications,
including
tissue
engineering
and
medical
devices,
due
to
their
ability
imitate
the
natural
extracellular
matrix
(ECM)
of
tissues.
However,
conventional
static
hydrogels
lack
dynamically
respond
changes
surroundings
withstand
robust
biophysical
microenvironment
trigger
on-demand
functionality
such
as
drug
release
mechanical
change.
In
contrast,
multifunctional
dynamic
can
adapt
external
stimuli
drawn
great
attention
recent
studies.
It
is
realized
that
integration
nanomaterials
into
provides
numerous
functionalities
for
a
variety
applications
cannot
be
achieved
by
hydrogels.
This
review
article
comprehensive
overview
advances
designing
fabricating
applications.
We
describe
different
types
based
on
breakable
reversible
covalent
bonds
well
noncovalent
interactions.
These
mechanisms
are
described
detail
useful
reference
crosslinking
strategies
strongly
influence
properties
also
discuss
use
potential
benefits.
further
explores
nanocomposite
hydrogels,
delivery,
engineering,
bioadhesives,
wound
healing,
cancer
treatment,
mechanistic
study,
multiple-scale
Finally,
we
challenges
future
perspectives
field
diverse
technologies.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(20), P. 7039 - 7039
Published: Oct. 12, 2023
Large
bone
defects
due
to
trauma,
infections,
and
tumors
are
difficult
heal
spontaneously
by
the
body’s
repair
mechanisms
have
become
a
major
hindrance
people’s
daily
lives
economic
development.
However,
autologous
allogeneic
grafts,
with
their
lack
of
donors,
more
invasive
surgery,
immune
rejection,
potential
viral
transmission,
hinder
development
repair.
Hydrogel
tissue
bioengineered
scaffolds
gained
widespread
attention
in
field
good
biocompatibility
three-dimensional
network
structure
that
facilitates
cell
adhesion
proliferation.
In
addition,
loading
natural
products
nanoparticles
incorporating
them
into
hydrogel
is
one
most
effective
strategies
promote
bioactivity
limitations
products.
Therefore,
this
paper
presents
brief
review
application
hydrogels
different
gel-forming
properties,
matrices,
nanoparticle-loaded
loaded
incorporated
for
defect
recent
years.
Maxillofacial Plastic and Reconstructive Surgery,
Journal Year:
2024,
Volume and Issue:
46(1)
Published: April 16, 2024
Abstract
This
narrative
review
systematically
explores
the
progression
of
materials
and
techniques
in
alveolar
ridge
preservation
(ARP).
We
commence
by
delineating
evolution
from
traditional
ARP
methods
to
cutting-edge
alternatives,
including
platelet-rich
fibrin,
injectable
bone
repair
materials,
hydrogel
systems.
Critical
examination
various
studies
reveals
these
innovative
approaches
not
only
accelerate
healing
but
also
significantly
improve
patient-reported
outcomes,
such
as
satisfaction,
pain
perception,
overall
quality
life.
Emphasis
is
placed
on
correlation
between
advanced
enhanced
patient
comfort
clinical
efficacy,
underscoring
their
transformative
potential
dental
implantology.
Highlighting
effectiveness
ARP,
implant
survival
rate
over
a
span
5
7
years
was
high,
showcasing
reliability
success
methods.
Further,
patients
expressed
high
aesthetic
satisfaction
with
soft
tissue
outcome,
evidenced
an
average
visual
analog
scale
(VAS)
score
94.
positive
appraisal
linked
health
implants,
potentially
due
employment
tooth-supported
surgical
guides.
The
economic
analysis
varied
cost
range
for
graft
substitutes
($46.2
$140)
socket
sealing
($12
$189),
noteworthy
investment
barrier
membranes
diminished
horizontal
vertical
resorption.
suggests
that
membrane
usage
contributes
preserving
dimensions,
offering
cost-effective
strategy
enhancing
outcomes.
In
conclusion,
this
illuminates
significant
advancements
highlighting
shift
towards
promise
regeneration
reduced
times
documented
beneficial
implications
use
further
validate
contemporary
strategies,
paving
way
broader
adoption
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 593 - 593
Published: July 24, 2023
The
widespread
push
to
invest
in
local
cancer
therapies
comes
from
the
need
overcome
limitations
of
systemic
treatment
options.
In
contrast
intravenous
administration,
treatments
using
intratumoral
or
peritumoral
injections
are
independent
tumor
vasculature
and
allow
high
concentrations
therapeutic
agents
reach
site
with
minimal
toxicity.
Injectable
biodegradable
hydrogels
offer
a
clear
advantage
over
other
delivery
systems
because
former
requires
no
surgical
procedures
promotes
drug
retention
at
site.
More
precisely,
situ
gelling
based
on
poloxamers
have
garnered
considerable
attention
due
their
thermoresponsive
behavior,
biocompatibility,
ease
preparation,
possible
incorporation
different
anticancer
agents.
Therefore,
this
review
focuses
use
injectable
physicochemical
biological
characterization.
It
also
includes
summary
these
hydrogel
applications
chemotherapy,
phototherapy,
immunotherapy,
gene
therapy.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(4), P. 042007 - 042007
Published: April 18, 2024
Bone
tissue
engineering
(BTE)
provides
the
treatment
possibility
for
segmental
long
bone
defects
that
are
currently
an
orthopedic
dilemma.
This
review
explains
different
strategies,
from
biological,
material,
and
preparation
points
of
view,
such
as
using
stem
cells,
ceramics,
metals,
their
corresponding
properties
BTE
applications.
In
addition,
factors
porosity,
surface
chemistry,
hydrophilicity
degradation
behavior
affect
scaffold
success
introduced.
Besides,
most
widely
used
production
methods
result
in
porous
materials
discussed.
Gene
delivery
secretome-based
therapies
also
introduced
a
new
generation
therapies.
outlines
positive
results
important
limitations
remaining
clinical
application
novel
defects.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 4, 2024
Abstract
Herein,
the
recent
advances
in
development
of
resorbable
polymeric‐based
biomaterials,
their
geometrical
forms,
resorption
mechanisms,
and
capabilities
various
biomedical
applications
are
critically
reviewed.
A
comprehensive
discussion
engineering
approaches
for
fabrication
polymeric
scaffolds
tissue
engineering,
drug
delivery,
surgical,
cardiological,
aesthetical,
dental
cardiovascular
applications,
also
explained.
Furthermore,
to
understand
internal
structures
scaffolds,
representative
studies
evaluation
by
medical
imaging
techniques,
e.g.,
cardiac
computer
tomography,
succinctly
highlighted.
This
approach
provides
crucial
clinical
insights
which
help
improve
materials’
suitable
viable
characteristics
them
meet
highly
restrictive
requirements.
Finally,
aspects
legal
regulations
associated
challenges
translating
research
into
desirable
marketable
materials
formulations,
presented.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
The
effective
regeneration
of
bone/cartilage
defects
remains
a
significant
clinical
challenge,
causing
irreversible
damage
to
millions
annually.Conventional
therapies
such
as
autologous
or
artificial
bone
grafting
often
yield
unsatisfactory
outcomes,
emphasizing
the
urgent
need
for
innovative
treatment
methods.
Biomaterial-based
strategies,
including
hydrogels
and
active
scaffolds,
have
shown
potential
in
promoting
regeneration.
Among
them,
injectable
garnered
substantial
attention
recent
years
on
account
their
minimal
invasiveness,
shape
adaptation,
controlled
spatiotemporal
release.
This
review
systematically
discusses
synthesis
hydrogels,
bioinspired
approaches-covering
microenvironment,
structural,
compositional,
bioactive
component-inspired
strategies-and
applications
various
disease
models,
highlighting
from
an
perspective
design.
Taken
together,
offer
promising
feasible
solutions
regeneration,
ultimately
laying
foundations
applications.
Furthermore,
insights
into
further
prospective
directions
AI
screening
organoid
construction
are
provided.
