Journal of Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
ABSTRACT
Skin
defects
caused
by
injuries
such
as
burns
that
exceed
a
certain
diameter
no
longer
heal
spontaneously
and
require
more
complex
interventions.
Hydrogels
have
received
special
attention
due
to
their
unique
ability
block
the
penetration
of
bacteria
into
wounds
they
can
absorb
contaminated
exudates
exhibit
high
degree
flexibility.
This
study
is
focused
on
preparation
characterization
novel
antibacterial
biocomposite
hydrogels
based
two
carbohydrates,
alginate
hyaluronic
acid
(HA),
with
immobilized
ZnO
NPs
curcumin‐loaded
electrospun
nanofibers
improve
efficacy
wound
healing
process.
The
hydrogel
matrix
was
obtained
after
crosslinking
HA
in
presence
DMT‐MM
activator.
were
physicochemically
characterized
FT‐IR,
scanning
electron
microscopy
(SEM),
UV–Vis
spectroscopy,
swelling
also
investigated.
It
appeared
behavior
influenced
amount
nanofibers.
Biodegradability,
hemolysis,
cell
viability,
antimicrobial,
vitro
irritability
tests
carried
out
assess
biological
properties.
results
highlighted
these
are
biodegradable,
hemocompatible,
non‐cytotoxic,
non‐irritating
good
antimicrobial
activity.
Based
results,
materials
might
be
interesting
candidates
for
treatment.
Journal of Polymer Science,
Journal Year:
2024,
Volume and Issue:
62(11), P. 2320 - 2339
Published: March 8, 2024
Abstract
Bacterial
infections
are
common
during
skin
wound
healing,
which
can
interrupt
the
healing
process,
delay
and
seriously
affect
quality
of
life.
Long‐term
antibiotic
treatment
may
lead
to
development
drug
resistance.
Traditional
bandages,
sponges,
films,
textiles
commonly
single‐functional,
usually
fail
satisfy
complicated
needs
process.
In
recent
years,
antibacterial
hydrogel
dressings
have
received
extensive
attention
for
infected
chronic
wounds,
serve
as
biocompatible,
multifunctional
platforms
both
promoting
tissue
regeneration
inhibiting
bacterial
infection.
Cationic
polymers
with
inherent
properties
been
used
backbone,
metal
ions
nanoparticles
be
loaded
in
hydrogels
enhance
effects.
Besides,
various
drugs
bioactive
factors
incorporated
provide
anti‐inflammatory
antioxidant
activities
environment
healing.
Additionally,
adhesion
advantages
fixing
at
sites
dressing‐tissue
interactions.
this
review,
we
focus
on
designing
strategies
tissue‐adhesive,
antibacterial,
naturally‐derived
polymer
treating
wounds.
The
typical
mechanisms
summarized.
Finally,
prospects
challenges
further
multi‐functional
treat
wounds
proposed.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
11(2), P. 363 - 387
Published: Nov. 2, 2023
Wound
healing
is
a
complex
process
that
requires
effective
management
to
prevent
infections
and
promote
efficient
tissue
regeneration.
In
recent
years,
upconversion
nanoparticles
(UCNPs)
have
emerged
as
promising
materials
for
wound
dressing
applications
due
their
unique
optical
properties
potential
therapeutic
functionalities.
These
possess
enhanced
antibacterial
when
functionalized
with
agents,
helping
infections,
common
complication
in
healing.
They
can
serve
carriers
controlled
drug
delivery,
enabling
targeted
release
of
agents
the
site,
allowing
tailored
treatment
optimal
conditions.
ability
convert
near-infrared
(NIR)
light
into
visible
and/or
ultraviolet
(UV)
regions,
making
them
suitable
(photothermal
therapy
photodynamic
therapy)
diagnostic
applications.
context
healing,
these
be
combined
other
such
hydrogels,
fibers,
metal-organic
frameworks
(MOFs),
graphene
oxide,
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(7), P. 4344 - 4357
Published: June 25, 2024
Wound
dressings
made
from
natural-derived
polymers
are
highly
valued
for
their
biocompatibility,
biodegradability,
and
biofunctionality.
However,
natural
polymer-based
hydrogels
can
come
with
own
set
of
limitations,
such
as
low
mechanical
strength,
limited
cell
affinity,
the
potential
cytotoxicity
cross-linkers,
which
delineate
boundaries
usage
hamper
practical
application.
To
overcome
limitation
polymers,
this
study
utilized
a
mixture
oxidized
alginate
gelatin
5
mg/mL
polycaprolactone
(PCL):gelatin
nanofiber
fragments
at
ratio
7:3
(OGN-7)
to
develop
hydrogel
composite
wound
dressing
that
be
injected
has
ability
remended.
The
in
situ
formation
remendable
is
facilitated
by
dual
cross-linking
chains
PCL/gelatin
nanofibers
through
Schiff-base
mechanisms,
supported
physical
integration
nanofibers,
thereby
obviating
need
additional
agents.
Furthermore,
OGN-7
exhibits
increased
stiffness
(γ
=
79.4-316.3%),
reduced
gelation
time
(543
±
475
s),
improved
remendability
hydrogel,
excellent
biocompatibility.
Notably,
achieves
full
fusion
within
1
h
incubation
maintains
structural
integrity
under
external
stress,
effectively
overcoming
inherent
weaknesses
enhancing
therapeutic
efficacy
was
validated
full-thickness
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
12, P. 100184 - 100184
Published: June 26, 2024
Polyphenol
is
a
versatile
green
phytochemical
vital
in
several
biomedical
applications
with
fascinating
inherent
biocompatible,
bioadhesive,
antioxidant,
and
antibacterial
properties.
The
emergence
of
novel
nanotechnology
techniques,
such
as
electrospinning,
has
proven
to
be
an
excellent
option
for
nanotechnology,
ensuring
effective
drug
delivery
system
recognised
medicinal
plant
extracts
containing
polyphenols
electrospun
nanofibers
can
provide
the
necessary
environment
encapsulation.
Together,
have
shown
promising
usage
wound
healing.
When
are
incorporated
into
nanofibrous
scaffolds,
their
combined
properties
enhance
cell
attachment,
proliferation,
differentiation.
This
review
explores
potential
polyphenol-loaded
therapy,
highlighting
importance
efficient
systems
polyphenols.
It
provides
brief
assessment
specific
(resveratrol,
curcumin,
thymol,
quercetin,
tannic
acid,
ferulic
hesperidin,
gallic
kaempferol,
chlorogenic
acid)
that
been
successfully
encapsulated
applied
treatment.
Despite
ongoing
research,
certain
carvacrol,
oleuropein,
kaempferol
remain
less
explored.
underscores
need
continued
investigation
these
while
recognising
growing
application
healing
more
extensive
therapeutic
use.
Current Drug Targets,
Journal Year:
2023,
Volume and Issue:
24(16), P. 1239 - 1259
Published: Nov. 9, 2023
The
diabetic
wound
is
excessively
vulnerable
to
infection
because
the
suggests
delayed
and
incomplete
healing
techniques.
Presently,
wounds
ulcers
related
diabetes
have
additionally
increased
medical
burden.
A
can
impair
mobility,
lead
amputations,
or
even
death.
In
recent
times,
advanced
drug
delivery
systems
emerged
as
promising
approaches
for
enhancing
efficacy
of
treatments
in
patients.
This
review
aims
provide
an
overview
current
advancements
managing
chronic
healing.
begins
by
discussing
pathophysiological
features
wounds,
including
impaired
angiogenesis,
elevated
reactive
oxygen
species,
compromised
immune
response.
These
factors
contribute
susceptibility
infection.
importance
early
intervention
effective
management
strategies
emphasized.
Various
types
are
then
explored,
nanoparticles,
hydrogels,
transferosomes,
liposomes,
niosomes,
dendrimers,
nanosuspension
with
incorporated
bioactive
agents
biological
macromolecules
also
utilized
management.
offer
advantages
such
sustained
release
therapeutic
agents,
improved
targeting
penetration,
enhanced
closure.
Additionally,
highlights
potential
novel
antibiotics,
minerals,
vitamins,
growth
gene
therapy,
stem
cell-based
therapy
outcome
holds
immense
They
innovative
delivering
improving
closure,
addressing
specific
characteristics
wounds.
