The role of mechanically sensitive ion channel Piezo1 in bone remodeling DOI Creative Commons

Yugui Du,

Bowen Xu,

Quiying Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 8, 2024

Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such tension, osmotic pressure, and shear force. mediates mechanosensory transduction in different organs tissues, including its role maintaining bone homeostasis. This review aimed to summarize the function possible mechanism mechanical receptor cells tissue. We found that it is potential therapeutic target for treatment diseases.

Language: Английский

Regulation of Joint Tissues and Joint Function: Is There Potential for Lessons to Be Learned Regarding Regulatory Control from Joint Hypermobility Syndromes? DOI Open Access
David A. Hart

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1256 - 1256

Published: Jan. 31, 2025

Normal development of joints starts in utero with the establishment a cellular and extracellular matrix template. Following birth, individual joint tissues grow mature response to biochemical mechanical signals, leading coordinated pattern further maturation resulting that functions as an organ system. Each develops matures system defined by biomechanical environment which it will function. For those hypermobility syndromes, either specific genetic mutations or not (i.e., Ehlers–Danlos syndrome, Marfan Loey–Dietz hypermobility-type syndrome), this process is partially compromised, but many aspects tissue function retained such organs form retain partial function, compromised. Comparing characteristics what known regarding development, growth, maturation, stressors puberty, pregnancy, aging without leads conclusion have systems may be compromised via failure undergo possibly defective mechanotransduction. Given breadth involved characterization concept reveal commonalities their impact on inform regulatory normal functional integrity. This review/perspective piece attempt detail comparisons summarize how study aid understanding.

Language: Английский

Citations

1
Nociceptor mechanisms underlying pain and bone remodeling via orthodontic forces: toward no pain, big gain DOI Creative Commons
Sheng Wang, Ching‐Chang Ko, Man‐Kyo Chung

et al.

Frontiers in Pain Research, Journal Year: 2024, Volume and Issue: 5

Published: Feb. 22, 2024

Orthodontic forces are strongly associated with pain, the primary complaint among patients wearing orthodontic braces. Compared to other side effects of treatment, pain is often overlooked, limited clinical management. lead inflammatory responses in periodontium, which triggers bone remodeling and eventually induces tooth movement. Mechanical subsequent inflammation periodontium activate sensitize periodontal nociceptors produce pain. Nociceptive afferents expressing transient receptor potential vanilloid subtype 1 (TRPV1) play central roles transducing nociceptive signals, leading transcriptional changes trigeminal ganglia. molecules, such as TRPV1, ankyrin 1, acid-sensing ion channel 3, P2X3 receptor, believed mediate Neuropeptides calcitonin gene-related peptides substance P can also regulate While transmit signals brain, they known modulate alveolar periodontitis. Therefore, molecules may contribute modulation movement, currently remains undetermined. Future studies needed better understand fundamental mechanisms underlying neuroskeletal interactions orthodontics improve treatment by developing novel methods reduce accelerate movement—thereby achieving “big gains no pain” orthodontics.

Language: Английский

Citations

5
Effective description of dental thermal pain sensation via the Hodgkin–Huxley equations DOI
Yi‐Ming Chen, Jia Mi,

Yuancheng Zhang

et al.

Nonlinear Dynamics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Piezo1 promotes double-directional differentiation from human periodontal ligament progenitor cells DOI

Yuri Kono,

Hiroshi Kajiya, R Nagano

et al.

Journal of Oral Biosciences, Journal Year: 2025, Volume and Issue: unknown, P. 100651 - 100651

Published: March 1, 2025

Language: Английский

Citations

0
Utilizing vibration as a method for accelerating tooth movement during orthodontic treatment: a systematic review and meta-analysis DOI Creative Commons

Shubhobrata Dutta,

Amol Patil,

Sonakshi Sharma

et al.

Clinical and Investigative Orthodontics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: April 2, 2025

Language: Английский

Citations

0
Beyond hydrodynamics: The role of ion channels in dentine hypersensitivity DOI

Yutong Sun,

Andrea Sanders,

David H. Pashley

et al.

Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown, P. 105745 - 105745

Published: April 1, 2025

Language: Английский

Citations

0
The role of mechanically sensitive ion channel Piezo1 in bone remodeling DOI Creative Commons

Yugui Du,

Bowen Xu,

Quiying Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 8, 2024

Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such tension, osmotic pressure, and shear force. mediates mechanosensory transduction in different organs tissues, including its role maintaining bone homeostasis. This review aimed to summarize the function possible mechanism mechanical receptor cells tissue. We found that it is potential therapeutic target for treatment diseases.

Language: Английский

Citations

3