Trending Topics on Coumarin and Its Derivatives in 2020

Molecules, Journal Year: 2021, Volume and Issue: 26(2), P. 501 - 501

Published: Jan. 19, 2021

Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them privileged scaffold in medicinal chemistry chemical biology. Many research articles reviews compile information on this important family compounds. In overview, the most recent papers from 2020 organized analyzed, discussion these data is included. Multiple electronic databases were scanned, including SciFinder, Mendeley, PubMed, latter being main source information. Particular attention was paid to potential coumarins as an drug design, well fluorescent probes for decaging prodrugs, metal detection, diagnostic purposes. Herein we do analysis trending topics related coumarin its derivatives broad field discovery.

Language: Английский

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Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

RSC Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 15(1), P. 10 - 54

Published: Oct. 20, 2023

Many researchers around the world are working on development of novel anticancer drugs with different mechanisms action. In this case, coumarin is a highly promising pharmacophore for drugs. Besides, hybridization moiety other pharmacophores has emerged as potent breakthrough in treatment cancer to decrease its side effects and increase efficiency. This review aims provide comprehensive overview recent derivatives their application Herein, we highlight describe largest number research works reported field from 2015 August 2023, along action structure-activity relationship studies, making articles published topic date.

Language: Английский

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Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1026 - 1026

Published: Feb. 27, 2024

Molecular hybridization represents a new approach in drug discovery which specific chromophores are strategically combined to create novel drugs with enhanced therapeutic effects. This innovative strategy leverages the strengths of individual address complex biological challenges, synergize beneficial properties, optimize pharmacokinetics, and overcome limitations associated single-agent therapies. Coumarins documented possess several bioactivities have therefore been targeted for combination other active moieties molecular hybrids. review summarizes recent (2013–2023) trends synthesis coumarins, as well coumarin–chalcone coumarin–triazole To cover wide aspects this area, we included differently substituted chalcones, 1,2,3– 1,2,4–triazoles considered point fusion/attachment coumarin show diversity these The reported syntheses mainly relied on well-established chemistry without need strict reaction conditions usually produced high yields. Additionally, discussed compounds, including antioxidative, antimicrobial, anticancer, antidiabetic, anti-cholinesterase activities commented their IC50 where possible. Promising bioactivity results obtained so far. It is noted that mechanistic studies infrequently found published work, was also mentioned give reader better understanding. aims provide valuable information enable further developments field.

Language: Английский

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Coumarin-based derivatives with potential anti-HIV activity

Fitoterapia, Journal Year: 2021, Volume and Issue: 150, P. 104863 - 104863

Published: Feb. 11, 2021

Language: Английский

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Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry

European Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 227, P. 113921 - 113921

Published: Oct. 21, 2021

Language: Английский

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Electrochemical transient iodination and coupling for selenylated 4-anilinocoumarin synthesis

Green Synthesis and Catalysis, Journal Year: 2021, Volume and Issue: 2(2), P. 233 - 236

Published: April 8, 2021

An electrochemical transient iodination and coupling reaction has been designed for constructing selenylated 4-anilinocoumarins via the domino reactions of diorganyl diselenides under base-, chemical oxidant- external electrolyte-free conditions.

Language: Английский

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A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: Dec. 1, 2021

The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial anticancer agents as well enzyme inhibitors. On the other hand, it has been reported incorporation metal ion into derivatives can increase activity such complexes compared to coumarin-based ligands. Accordingly, some them have found display promising antitumor or antibacterial activities. This mini-review briefly summarizes recent development coumarin-metal with proven properties. attention also paid for which practical applications detection biologically important species may be found.

Language: Английский

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Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship

Journal of Clinical Pharmacy and Therapeutics, Journal Year: 2022, Volume and Issue: 47(7), P. 915 - 931

Published: March 15, 2022

What is known and objective The main of this review to highlight the most relevant studies since 1990 (to date) in area medicinal chemistry aspects provide a panoramic view biologists/medicinal chemists working would assist them their efforts design, synthesize extract (from natural source) coumarin-based anticonvulsant agents. Also, structure–activity relationship (SAR) are also discussed for further rational design kind derivatives. It hoped that will be helpful new thoughts quest designs more active less toxic antiepileptic Methods A literature emphasizing application coumarin core as agents identify articles related topic; we performed standardized search from November 2021, using engines like Scifinder, web Science, Pubmed Scopus. Results discussion This gives an overview attempts shed light compile published reports on derivatives along with some opinions different approaches help designing future generation potent yet safer possible relationships (SARs) indicate direction effective candidates. conclusion findings indications or directions discovery better drugs synthetic naturally occurring coumarins In our review, have tried depict recent researches which made development novel compounds nucleus. SAR expressed indicated choice fitting substitution containing electron-withdrawing/donating groups heterocyclic moieties joined parent skeleton assumes essential role changing activity synthesized These encourage scientific community towards optimization pharmacological profile structural moiety important scaffold treatment epilepsy.

Language: Английский

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Natural Coumarin Derivatives Activating Nrf2 Signaling Pathway as Lead Compounds for the Design and Synthesis of Intestinal Anti-Inflammatory Drugs

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 511 - 511

Published: March 30, 2023

Nrf2 (nuclear factor erythroid 2-related 2) is a transcription related to stress response and cellular homeostasis that plays key role in maintaining the redox system. The imbalance of system triggering for initiation progression non-communicable diseases (NCDs), including Inflammatory Bowel Disease (IBD). its inhibitor Kelch-like ECH-associated protein 1 (Keap1) are main regulators oxidative their activation has been recognized as promising strategy treatment or prevention several acute chronic diseases. Moreover, Nrf2/keap signaling pathway promotes inhibition NF-κB, transcriptional pro-inflammatory cytokines expression, synchronically promoting an anti-inflammatory response. Several natural coumarins have reported potent antioxidant intestinal compounds, acting by different mechanisms, mainly modulator pathway. Based on vivo vitro studies, this review focuses obtained from both plant products fermentative processes food plants gut microbiota, which activate produce activity. Although metabolites urolithin A B well other plant-derived display activity modulating pathway, studies necessary better pharmacological characterization evaluation potential lead compounds. Esculetin, 4-methylesculetin, daphnetin, osthole, imperatorin most coumarin derivatives compounds design synthesis activators with However, further structure–activity relationships experimental models inflammation subsequent clinical trials health disease volunteers essential determine efficacy safety IBD patients.

Language: Английский

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Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6099 - 6099

Published: June 1, 2024

Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing death. This mode action, as well their ability be modified targeted, makes them promising avenue for advancing therapy. We are investigating the molecular mechanisms underlying interactions cells, particular interfere cellular processes induce apoptosis. The properties not accidental but due chemical structure reactivity. electrophilic nature these allows selectively target residues on disease-associated proteins, resulting significant therapeutic benefits minimal toxicity various diseases. opens up new perspectives development more effective precise drugs. Nevertheless, further studies essential fully understand impact our discoveries translate into clinical practice.

Language: Английский

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