Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 480, P. 215020 - 215020

Published: Jan. 25, 2023

Language: Английский

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Natural Coumarin Derivatives Activating Nrf2 Signaling Pathway as Lead Compounds for the Design and Synthesis of Intestinal Anti-Inflammatory Drugs

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 511 - 511

Published: March 30, 2023

Nrf2 (nuclear factor erythroid 2-related 2) is a transcription related to stress response and cellular homeostasis that plays key role in maintaining the redox system. The imbalance of system triggering for initiation progression non-communicable diseases (NCDs), including Inflammatory Bowel Disease (IBD). its inhibitor Kelch-like ECH-associated protein 1 (Keap1) are main regulators oxidative their activation has been recognized as promising strategy treatment or prevention several acute chronic diseases. Moreover, Nrf2/keap signaling pathway promotes inhibition NF-κB, transcriptional pro-inflammatory cytokines expression, synchronically promoting an anti-inflammatory response. Several natural coumarins have reported potent antioxidant intestinal compounds, acting by different mechanisms, mainly modulator pathway. Based on vivo vitro studies, this review focuses obtained from both plant products fermentative processes food plants gut microbiota, which activate produce activity. Although metabolites urolithin A B well other plant-derived display activity modulating pathway, studies necessary better pharmacological characterization evaluation potential lead compounds. Esculetin, 4-methylesculetin, daphnetin, osthole, imperatorin most coumarin derivatives compounds design synthesis activators with However, further structure–activity relationships experimental models inflammation subsequent clinical trials health disease volunteers essential determine efficacy safety IBD patients.

Language: Английский

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Coumarins as versatile therapeutic phytomolecules: A systematic review

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155972 - 155972

Published: Aug. 30, 2024

Language: Английский

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Natural linear coumarin-heterocyclic conjugates: A review of their roles in phytotherapy

Fitoterapia, Journal Year: 2024, Volume and Issue: 175, P. 105929 - 105929

Published: March 27, 2024

Language: Английский

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Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6099 - 6099

Published: June 1, 2024

Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing death. This mode action, as well their ability be modified targeted, makes them promising avenue for advancing therapy. We are investigating the molecular mechanisms underlying interactions cells, particular interfere cellular processes induce apoptosis. The properties not accidental but due chemical structure reactivity. electrophilic nature these allows selectively target residues on disease-associated proteins, resulting significant therapeutic benefits minimal toxicity various diseases. opens up new perspectives development more effective precise drugs. Nevertheless, further studies essential fully understand impact our discoveries translate into clinical practice.

Language: Английский

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Synthesis of anthraquinone-connected coumarin derivatives via grindstone method and their evaluation of antibacterial, antioxidant, tyrosinase inhibitory activities with molecular docking, and DFT calculation studies

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25168 - e25168

Published: Jan. 29, 2024

Anthraquinones and coumarins have excellent pharmacological activities are an important class of natural plant metabolites with various biological activities. In this study, anthraquinone-9,10-dione coumarin derivatives were combined to develop a novel anthraquinone-connected coumarin-derivative sequence. The synthesised (1a-t) screened for in vitro antibacterial, antioxidant, tyrosinase inhibitory antibacterial the compounds (1a–t) tested against both gram-positive gram-negative bacteria. Specifically, compound 1t was more active E. aerogenes than ciprofloxacin. With regard antioxidant activity, 1o (50.68 % at 100 μg/mL) highly compared other compounds, whereas it less standard BHT (76.74 μg/mL). terms 1r (9.31 ± 0.45 activity kojic acid (10.42 0.98 molecular docking had higher score (−8.8 kcal mol−1) (−1.7 mol−1). DFT calculations performed determine energy gap (ΔE = 0.11) weakly 1a 0.12). we found that every molecule displayed significant properties. Based on these reports, may act as multi-target agents.

Language: Английский

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Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3521 - 3521

Published: March 20, 2024

The phrase “Let food be thy medicine…” means that can a form of medicine and food; in other words, the diet we eat have significant impact on our health well-being. Today, this is gaining prominence as more scientific evidence suggests one’s help prevent treat disease. A rich fruits, vegetables, whole grains, lean protein reduce risk heart disease, cancer, diabetes, problems and, hand, processed foods, added sugars, saturated fats increase same diseases. Electrophilic compounds health, they are molecules covalently modify cysteine residues present thiol-rich Keap1 protein. These bind to activate NRF2, which promotes its translocation nucleus binding DNA ARE region, triggering antioxidant response protecting against oxidative stress. include polyphenols flavonoids nucleophilic but converted electrophilic quinones by metabolic enzymes such polyphenol oxidases (PPOs) sulfur foods Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) garlic. This review summarizes current knowledge subject.

Language: Английский

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Characterization and In-vitro Release of Coumarin from Folic Acid-Conjugated Mesoporous Silica for Targeted Cancer Therapy

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141502 - 141502

Published: Jan. 1, 2025

Language: Английский

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Recent Advances in the One-Pot Synthesis of Coumarin Derivatives from Different Starting Materials Using Nanoparticles: A Review

Topics in Catalysis, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 27, 2022

Language: Английский

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New coumarin derivative with potential antioxidant activity: Synthesis, DNA binding and in silico studies (Docking, MD, ADMET)

Arabian Journal of Chemistry, Journal Year: 2022, Volume and Issue: 16(2), P. 104440 - 104440

Published: Nov. 26, 2022

A new coumarin derivative, 7-((8-(4-benzylpiperidin-1-yl)octyl)oxy)-4-methyl-2H-chromen-2-one (C3), was synthesized by two-step alkylation reaction of 7-hydroxy-4-methyl coumarin. The structure and purity the compound were characterized its 1H 13C NMR, FT-IR LC-MS spectral data. DNA binding interaction C3 evaluated using UV–vis spectrophotometric viscosimetric methods. These experiments showed that bound in intercalative mode. antioxidant activity DPPH method, results displayed had radical scavenging effect. possible mechanism anticancer investigated via molecular docking two enzymes CYP450 EGFR as receptors. also tended a good ability based on result analysis, with affinity values (-7.82 kcal/mol) site interactions. Molecular Dynamics (MD) simulation implemented to elucidate interactions protein–ligand complex 20 ns. ADMET analyzes which paved way for us predict drug candidate performed. All experimental theoretical potential an agent.

Language: Английский

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