Fibroblasts derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation DOI Creative Commons
Hongchen Sun,

Feilong Ren,

Shize Zheng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Complement C3 plays a critical role in periodontitis. However, its source, and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that is primarily derived periodontal fibroblasts. Subsequently, demonstrated C3a has detrimental effect ligature-induced C3ar-/- mice exhibited significantly less destruction support tissues compared to wild-type mice, characterized mild gingival tissue damage reduced alveolar bone loss. This reduction was associated with decreased production pro-inflammatory mediators osteoclast infiltration the tissues. Mechanistic studies suggested could promote macrophage polarization differentiation. Finally, patients found results observed were consistent human data. Therefore, findings clearly demonstrate destructive fibroblast-derived driven M1 These strongly feasibility C3a-targeted interventions for treatment

Language: Английский

Sequential immunotherapy: towards cures for autoimmunity DOI
Francisco Ramírez‐Valle, Joseph Maranville,

Sophie Roy

et al.

Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: 23(7), P. 501 - 524

Published: June 5, 2024

Language: Английский

Citations

12
The role of complement in tumor immune tolerance and drug resistance: a double-edged sword DOI Creative Commons
Ronghui Yang, Di Fu, Aijun Liao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

The domain of cancer treatment has persistently been confronted with significant challenges, including those associated recurrence and drug resistance. complement system, which serves as the foundation innate immune exhibits intricate nuanced dual characteristics in evolution tumors. On one hand, system capacity to directly inhibit cell proliferation via specific pathways, thereby exerting a beneficial anti-tumor effect. Conversely, can also facilitate establishment an escape barrier for cells through non-complement-mediated mechanisms, protecting them from eradication. Concurrently, be implicated emergence resistance multitude complex or indirectly reducing efficacy therapeutic interventions facilitating progression cancer. This paper analyses role tumors reviews recent research advances mechanisms tumor tolerance

Language: Английский

Citations

1
Omega-3 fatty acids supplementation from late pregnancy to early lactation attenuates the endocannabinoid system and immune proteome in preovulatory follicles and endometrium of Holstein dairy cows DOI Creative Commons

P. dos S. Silva,

Yana Butenko,

Gitit Kra

et al.

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Activation of the endocannabinoid system (ECS) elicits negative effects on reproductive in mammals. Omega-3 (n-3) fatty acid (FA) supplementation lowers ECS activation and has anti-inflammatory effects. Thus, we hypothesized that supplementing cows with n-3 FA will downregulate components immune preovulatory follicles endometrium. Twenty-four multiparous Holstein dairy were supplemented from d 256 pregnancy to 70 postpartum as follows: (i) control (CTL; n = 12) prepartum 250 g/d/cow calcium salts at 1.6% diet (DM basis); (ii) FLX (n 700 extruded flaxseed supplement rich α-linolenic (ALA, C18:3n-3), 6.4% basis) same supplement. Ovaries monitored 30 DIM, following estrous cycle synchronization aspirated follicular fluids (FF) ≥7 mm, separated granulosa cells (GC), performed endometrium biopsies 58 ± 5 DIM. The FF analyzed for concentrations estradiol (E2) progesterone (P4), E2-active declared when E2/P4 was >1. (eCB) profiles determined plasma tissues. Proteomic analyses mRNA abundances GC Supplementation increased proportion total decreased omega-6 (n-6) ratio plasma, compared CTL. In FF, n-6 eCB precursor arachidonic (AA; C20:4n-6), abundance FA-derived eicosapentaenoyl ethanolamide endometrium, reduced 2-arachidonoylglycerol (2-AG) analysis showed FA-binding-protein-5, which is involved intracellular transport eCB, well cytokine-receptor-like-factor-2 glutathione-S-transferase-LANCL1, whereas it several complement proteins: factors I, D, H, C7 chain C8 β chain, component 1 Q subcomponent-binding protein, mitochondrial (C1QBP). addition, superoxide-dismutase (SOD3) lower than a few immune-related proteins. GC, relative type 2 cannabinoids receptors Across treatments, positive correlation found between anandamide C7, C1QBP SOD3 GC; while 2-AG had them. Overall, line our premise, dietary attenuated levels some expression proteins genes related follicle may be part etiology cows.

Language: Английский

Citations

0
Inherent immunity and adaptive immunity: Mechanism and role in AECOPD DOI Creative Commons

Linguangjin Wu,

Eryun Zhang, Yadan Tu

et al.

Innate Immunity, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 1, 2025

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the leading cause hospitalization and mortality in COPD patients. The occurrence antibiotic resistance progression non-infectious diseases contribute to poor patient outcomes. Thus, a comprehensive understanding mechanisms underlying AECOPD essential for effective prevention. It widely acknowledged that immune system plays fundamental role pathogen clearance development inflammation. Immune dysregulation, either due deficiency or hyperactivity, has been implicated pathogenesis. Therefore, purpose this review investigate possible dysregulated function patients, specifically focusing on innate adaptive responses. ultimate aim provide new insights clinical prevention treatment strategies targeting AECOPD.

Language: Английский

Citations

0
Advances in acute COPD exacerbation: clarifying specific immune mechanisms of infectious and noninfectious factors DOI Creative Commons
Yadan Tu, Yong Chen,

Xuanhan Li

et al.

Therapeutic Advances in Respiratory Disease, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 1, 2025

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main cause hospitalization and death patients with disease. This largely due to bacterial resistance caused by clinical antibiotic abuse limited efficacy current treatment strategies in managing noninfectious AECOPD, which presents a significant challenge for clinicians. Therefore, it urgent prevention AECOPD fully understand specific mechanism immune system master key differences between infectious factors factors. article systematically discusses triggered various factors, including activation system, recruitment inflammatory cells role responses, through comprehensive review literature, this expounds existing targeted diagnosis methods technologies at different stages order provide new ideas AECOPD.

Language: Английский

Citations

0
Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation DOI Creative Commons

Feilong Ren,

Shize Zheng,

Huanyu Luo

et al.

International Journal of Oral Science, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 17, 2025

Abstract Complement C3 plays a critical role in periodontitis. However, its source, and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that is primarily derived periodontal fibroblasts. Subsequently, demonstrated C3a has detrimental effect ligature-induced C3ar −/− mice exhibited significantly less destruction support tissues compared to wild-type mice, characterized mild gingival tissue damage reduced alveolar bone loss. This reduction was associated with decreased production pro-inflammatory mediators osteoclast infiltration the tissues. Mechanistic studies suggested could promote macrophage polarization differentiation. Finally, patients found results observed were consistent human data. Therefore, findings clearly demonstrate destructive fibroblast-derived driven M1 These strongly feasibility C3a-targeted interventions for treatment

Language: Английский

Citations

0
Proteomic and Lipidomic Profiling of Calves Experimentally Co-Infected with Influenza D Virus and Mycoplasma bovis: Insights into the Host–Pathogen Interactions DOI Creative Commons
Ignacio Álvarez, Mariette Ducatez, Yongzhi Guo

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 361 - 361

Published: Feb. 27, 2024

The role of Influenza D virus (IDV) in bovine respiratory disease remains unclear. An vivo experiment resulted increased clinical signs, lesions, and pathogen replication calves co-infected with IDV Mycoplasma bovis (M. bovis), compared to single-infected calves. present study aimed elucidate the host–pathogen interactions profile kinetics lipid mediators airways these Bronchoalveolar lavage (BAL) samples collected at 2 days post-infection (dpi) were used for proteomic analyses by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Additionally, lipidomic performed LC-MS/MS on BAL 2, 7 14 dpi. Whereas M. induced expression proteins involved fibrin formation, co-infection counteracted this coagulation mechanism downregulated other acute-phase response proteins, such as complement component 4 (C4) plasminogen (PLG). reduced inflammatory against likely delayed clearance, which led a significantly abundance oxylipids identified mainly derived from arachidonic acid; oxidized COX-1, COX-2, LOX-5; peaked This paper presents first characterization proteome mediator infection cattle raises hypotheses regarding how acts co-pathogen disease.

Language: Английский

Citations

3
Integrated serum proteomic and N‐glycoproteomic characterization of dengue patients DOI

Xiao Hu,

Jiamin Song,

Guoguo Ye

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(7)

Published: July 1, 2024

Abstract Dengue fever is a mosquito‐borne viral disease caused by the dengue virus (DENV). It poses public health threat globally and, while most people with have mild symptoms or are asymptomatic, approximately 5% of affected individuals develop severe and need hospital care. However, knowledge molecular mechanisms underlying infection interaction between its host remains limited. In present study, we performed quantitative proteomic N‐glycoproteomic analysis serum from 19 patients 11 healthy people. The results revealed distinct landscapes two groups. Notably, report for first time changes in N glycosylation pattern following provide abundant information on glycoproteins, sites, intact N‐glycopeptides using recently developed site‐specific glycoproteomic approaches. Furthermore, series key functional pathways were identified. Collectively, our findings significantly improve understanding DENV interactions general pathogenesis pathology DENV, laying foundation studies glycan structures infection.

Language: Английский

Citations

1
Rheumatoid factor levels indicate cryoglobulinemia severity in hepatitis B e antigen-negative hepatitis B virus carriers: a 7-year prospective cohort study DOI
J Wu, Wei-Ting Chen, Chung‐Guei Huang

et al.

Hepatology International, Journal Year: 2024, Volume and Issue: 19(1), P. 118 - 130

Published: Dec. 19, 2024

Language: Английский

Citations

1
“Rounding Third Base and Heading Home”: Arthritis & Rheumatology in 2024 DOI
Daniel H. Solomon, Mariana J. Kaplan, Peter A. Nigrović

et al.

Arthritis & Rheumatology, Journal Year: 2024, Volume and Issue: 76(6), P. 819 - 822

Published: April 4, 2024

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Language: Английский

Citations

0