YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes DOI Creative Commons

Zhi‐wei Feng,

Chen-fei Yang,

Hefang Xiao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 29, 2024

Rheumatoid arthritis (RA), a chronic autoimmune condition, is characterized by persistent synovial inflammation, bone degradation, and progressive joint deterioration. Despite considerable research efforts, the precise molecular mechanism underlying RA remains elusive. This investigation aims to elucidate potential role of N6-methyladenosine (m

Language: Английский

Rheumatoid arthritis: pathogenesis and therapeutic advances DOI Creative Commons
Ying Gao, Yunkai Zhang, Xingguang Liu

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved synovial inflammation for tissues‐destructive consequence, which remains one of significant causes disability and labor loss, affecting about 0.2–1% global population. Although treatments with disease‐modifying antirheumatic drugs (DMARDs) are effective to control decrease bone destruction, overall remission rates RA still stay at low level. Therefore, uncovering pathogenesis expediting clinical transformation imminently in need. Here, we summarize immunological basis, inflammatory pathways, genetic epigenetic alterations, metabolic disorders RA, highlights on abnormality immune cells atlas, epigenetics, immunometabolism. Besides an overview first‐line medications including conventional DMARDs, biologics, small molecule agents, discuss depth promising targeted therapies under or preclinical trials, especially regulators. Additionally, prospects precision medicine based biopsy RNA‐sequencing cell mesenchymal stem chimeric antigen receptor T‐cell also looked forward. The advancements innovations accelerates progress treatments.

Language: Английский

Citations

33
Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases DOI
Xinyue Zhou,

Yajie Wu,

Yingqiu Song

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 7, 2025

Language: Английский

Citations

1
Deciphering the Value of Anoikis-Related Genes in Prognosis, Immune Microenvironment, and Drug Sensitivity of Laryngeal Squamous Cell Carcinoma DOI
Cheng Wang, Ge Gao,

Qin Che

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 268, P. 155849 - 155849

Published: Feb. 25, 2025

Language: Английский

Citations

1
Recent advances of m6A methylation in skeletal system disease DOI Creative Commons

Jian‐Hui Liang,

Qian Yi,

Yang Liu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders skeletal with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position adenosine in RNA, reversible dynamic modification posttranscriptional mRNA. Evidences suggest that m6A modifications play crucial role regulating biological processes all kinds diseases, such malignancy. Recently studies have revealed most abundant epigentic modification, involved progression SSD. However, function SSD not fully illustrated. Therefore, make clear relationship between pathogenesis might provide novel sights for prevention targeted treatment This article will summarize recent advances regulation SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis osteoarthritis, discuss potential clinical value, research challenge future prospect

Language: Английский

Citations

5
Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes DOI Creative Commons
Guoqing Li,

Yuxuan Fang,

Nan Xu

et al.

Arthritis Research & Therapy, Journal Year: 2024, Volume and Issue: 26(1)

Published: Feb. 22, 2024

Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes disability worldwide. Exosomes released by fibroblast-like synoviocytes in RA (RA-FLSs-Exos) play role the development of RA, and circular RNAs (circRNAs) are important for progression. This study aimed to investigate molecular mechanisms underlying effects RA-FLSs-Exos identify potential pathway responsible these effects. Methods We initially conducted microarray analysis dysregulated circRNAs exosomes associated with RA. then co-cultured isolated chondrocytes examine their In vivo experiments were performed using collagen-induced mouse models, circFTO knockdown was achieved through intra-articular injection AAV5 vectors. Results Our findings revealed increased expression both synovial tissues from patients Exosomal hindered chondrocyte proliferation, migration, anabolism while promoting apoptosis catabolism. Mechanistically, we discovered facilitates formation methyltransferases complex suppress SRY-related high-mobility group box 9 (SOX9) assistance YTH domain family 2 (YTHDF2) an m6A-dependent mechanism. Furthermore, inhibition improved symptoms vivo. Conclusion Taken together, our demonstrates exosomal derived FLSs contributes progression targeting SOX9. These highlight promising target treating

Language: Английский

Citations

5
FTO-mediated RNA m6A methylation regulates synovial aggression and inflammation in rheumatoid arthritis DOI
Ruiru Li, Yu Kuang, Yuanyuan Niu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(7), P. 167341 - 167341

Published: July 16, 2024

Language: Английский

Citations

5
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids DOI
Xian Lin,

Tengyu Lin,

Xiaocheng Wang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 121, P. 155109 - 155109

Published: Sept. 21, 2023

Language: Английский

Citations

12
Epigenetic Regulatory Axis MIR22‐TET3‐MTRNR2L2 Represses Fibroblast‐Like Synoviocyte–Mediated Inflammation in Rheumatoid Arthritis DOI
Yilong Fang, Wei Huang,

Xiangling Zhu

et al.

Arthritis & Rheumatology, Journal Year: 2024, Volume and Issue: 76(6), P. 845 - 856

Published: Jan. 15, 2024

The specific role of fibroblast-like synoviocytes (FLSs) in the pathogenesis rheumatoid arthritis (RA) is still not fully elucidated. This study aimed to explore molecular mechanisms epigenetic pathways, including three factors, microRNA (miRNA)-22 (MIR22), ten-eleven translocation methylcytosine dioxygenase 3 (TET3), and MT-RNR2 like 2 (MTRNR2L2), RA-FLSs.

Language: Английский

Citations

5
Exploring the impact of m6A modification on immune diseases: mechanisms and therapeutic implication DOI Creative Commons
Yutong Chen, Min Liu,

Miao Lu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 12, 2024

N 6 -methyladenosine (m A) is a chemical modification of RNA and has become widely discussed topic among scientific researchers in recent years. It distributed various organisms, including eukaryotes bacteria. been found that m A composed writers, erasers readers involved biological functions such as splicing, transport translation RNA. The balance the human immune microenvironment important for health abnormalities. Increasing studies have affects development diseases inflammatory enteritis systemic lupus erythematosus (SLE) by participating homeostatic regulation vivo . In this manuscript, we introduce composition, function, its progression diseases, providing new targets directions treatment clinical practice.

Language: Английский

Citations

4
Increased Alleviation of Bone Destruction in Individuals with Rheumatoid Arthritis via the Coinhibition of the METTL3 and YTHDF1 Axis by the Combination of Triptolide and Medicarpin DOI Creative Commons
Yi Jiao, Zhaoran Wang,

Wenya Diao

et al.

Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0