Anti-Inflammatory and Active Biological Properties of the Plant-Derived Bioactive Compounds Luteolin and Luteolin 7-Glucoside

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1155 - 1155

Published: March 9, 2022

Flavonoids are interesting molecules synthetized by plants. They can be found abundantly in seeds and fruits, determining the color, flavor, other organoleptic characteristics, as well contributing to important nutritional aspects. Beyond these due their biochemical properties they considered bioactive compounds. Several studies have demonstrated biological activity different cellular physiological processes high-order organisms including humans. The flavonoid molecular structure confers capability of reacting with neutralizing reactive oxygen species (ROS), behaving scavengers all generating this class molecules, such UV irradiation, a process widely present plant physiology. Importantly, recent scientific literature has that flavonoids, human physiology, active compounds acting not only but also role counteracting inflammation process. Among wide variety significant results been shown investigating flavones luteolin luteolin-7-O-glucoside (LUT-7G). For compounds, experimental an anti-inflammatory action, both vitro vivo, interaction JAK/STAT3, NF-κB, pathways described review. We describe effects metabolic connected inflammation, glycolysis, diabetes, lipid peroxidation, cancer cells. Moreover, inhibition inflammatory pathway endothelial tissue, NLRP3 inflammasome assembly, demonstrates key progression phenomena. Since micronutrient obtained from food, open new perspectives respect long-term health status healthy individuals, use coadjutant treatment specific diseases.

Language: Английский

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Wumei Wan attenuates angiogenesis and inflammation by modulating RAGE signaling pathway in IBD: Network pharmacology analysis and experimental evidence

Phytomedicine, Journal Year: 2023, Volume and Issue: 111, P. 154658 - 154658

Published: Jan. 12, 2023

Wumei Wan (WMW) has been used to address digestive disorder for centuries in traditional Chinese medicine. Previous studies have demonstrated its anti-colitis efficacy, but the underlying mechanism of action remains be further clarified.To investigate mechanisms WMW treatment chronic ulcerative colitis (UC) through network pharmacology and experimental validation.Traditional Medicine Systems Pharmacology (TCMSP) platform were identify ingredients potential targets WMW. The microarray gene data GSE75214 datasets from GEO database was define UC-associated targets. Cytoscape3.7.2 employed construct protein-protein interaction (PPI) compounds-disease network. GO enrichment analysis KEGG pathway performed by R software functional annotation. UPLC-TOF-MS/MS method quantitatively analyze active For validation, three cycles 2% dextran sulfate sodium salt (DSS) model. hub signal detected qPCR, ELISA, western blotting , immunohistochemical immunofluorescence.Through analysis, 104 obtained WMW, 47 these had UC. A total 41 13 identified. showed that involved advanced glycation end products-receptor products (AGE-RAGE) signaling pathway. Taxifolin, rutaecarpine, kaempferol, quercetin, luteolin more highly predictive components related AGE-RAGE In vivo improved DSS-induced colitis, reduced expression inflammatory cytokines chemokines. Notably, it significantly decreased mRNA Spp1, Serpine1, Mmp2, Mmp9, Ptgs2, Nos2, Kdr Icam1, which associated with angiogenesis. addition, we confirmed inhibited RAGE diminished epithelial barrier alterations CONCLUSION: Our results initially effective strong anti-angiogenic activity colitis. Sufficient evidence satisfactory verified this study, suggesting as a quite prospective agent therapy

Language: Английский

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Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6324 - 6324

Published: March 28, 2023

Phytochemicals represent a large and diverse group of naturally occurring compounds, bioactive nutrients, or phytonutrients produced by plants, widely found in fruits, vegetables, whole grains products, legumes, beans, herbs, seeds, nuts, tea, dark chocolate. They are classified according to their chemical structures functional properties. Flavonoids belong the phenolic class phytochemicals with potential solid pharmacological effects as modulators multiple signal transduction pathways. Their beneficial effect on human body is associated antioxidant, anti-inflammatory, antimutagenic, anticarcinogenic also used various nutritional, pharmaceutical, medical, cosmetic applications. In our review, we discuss positive flavonoids chronic skin diseases such vitiligo, psoriasis, acne, atopic dermatitis.

Language: Английский

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Luteolin: A flavone with myriads of bioactivities and food applications

Food Bioscience, Journal Year: 2023, Volume and Issue: 52, P. 102366 - 102366

Published: Jan. 21, 2023

Language: Английский

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Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

Heliyon, Journal Year: 2023, Volume and Issue: 9(5), P. e15551 - e15551

Published: April 16, 2023

One of the adverse outcomes acute inflammatory response is progressing to chronic stage or transforming into an aggressive process, which can develop rapidly and result in multiple organ dysfunction syndrome. The leading role this process played by Systemic Inflammatory Response that accompanied production pro- anti-inflammatory cytokines, phase proteins, reactive oxygen nitrogen species.The purpose review highlights both recent reports results authors' own research encourage scientists new approaches differentiated therapy various SIR manifestations (low- high-grade systemic phenotypes) modulating redox-sensitive transcription factors with polyphenols evaluate saturation pharmaceutical market appropriate dosage forms tailored for targeted delivery these compounds.Redox-sensitive such as NFκB, STAT3, AP1 Nrf2 have a mechanisms formation low- phenotypes variants SIR. These phenotypic underlie pathogenesis most dangerous diseases internal organs, endocrine nervous systems, surgical pathologies, post-traumatic disorders.The use individual chemical compounds class polyphenols, their combinations be effective technology Administering natural oral very beneficial management number low-grade phenotype. associated phenotype requires medicinal phenol preparations manufactured parenteral administration.

Language: Английский

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The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1671 - 1671

Published: June 20, 2023

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis, alopecia, psoriasis, wounds, vitiligo, is associated with poor treatment outcomes. Improved comprehension the consequences PI3K/Akt/mTOR patients resulted development novel therapeutic approaches. Nonetheless, more studies are necessary to validate regulatory role this create effective preventive methods for a wide range skin diseases. Several have revealed that certain natural products synthetic compounds can obstruct expression/activity PI3K/Akt/mTOR, underscoring their potential managing common persistent disorders. This review summarizes recent advances understanding activated components discusses bioactive products, scaffolds, biologic agents prevention treatment. However, further research develop therapies

Language: Английский

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Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Nature Aging, Journal Year: 2024, Volume and Issue: 4(9), P. 1231 - 1248

Published: July 1, 2024

Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence thus improve healthspan. Here, we show daily oral administration standardized extract Salvia haenkei (Haenkenium (HK)) extended lifespan healthspan naturally aged mice. HK treatment inhibited age-induced inflammation, fibrosis markers across several tissues, as well increased muscle strength fur thickness compared with age-matched controls. We also found reduced acutely induced by chemotherapeutic agent doxorubicin, using p16

Language: Английский

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Luteolin enhanced antioxidant capability and induced pyroptosis through NF-κB/NLRP3/Caspase-1 in splenic lymphocytes exposure to ammonia

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170699 - 170699

Published: Feb. 5, 2024

Language: Английский

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The Promising Role of Polyphenols in Skin Disorders

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 865 - 865

Published: Feb. 15, 2024

The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. existing research suggests that plant phenolics, whether consumed orally or applied directly the skin, can be beneficial in alleviating symptoms and avoiding development many skin disorders. Phenolic compounds, which are both harmless naturally present, exhibit significant potential terms counteracting effects damage, aging, diseases, wounds, burns. Moreover, play a preventive role possess ability delay progression several disorders, ranging from small discomforting severe potentially life-threatening ones. This article provides concise overview recent therapeutic application for conditions. It specifically highlights studies have investigated clinical trials use polyphenol-based nanoformulations treatment different ailments.

Language: Английский

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Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155516 - 155516

Published: March 16, 2024

Recently, osteoblast pyroptosis has been proposed as a potential pathogenic mechanism underlying osteoporosis, although this remains to be confirmed. Luteolin (Lut), flavonoid phytochemical, plays critical role in the anti-osteoporosis effects of many traditional Chinese medicine prescriptions. However, its protective impact on osteoblasts postmenopausal osteoporosis (PMOP) not elucidated. This research aimed determine effect Lut ameliorating PMOP by alleviating and sustaining osteogenesis. was designed investigate novel both cell animal models. Ovariectomy-induced models were established mice with/without daily gavaged 10 or 20 mg/kg body weight Lut. The bone microstructure, metabolism oxidative stress evaluated with 0.104 Estradiol Valerate Tablets positive control. Network pharmacological analysis molecular docking employed mechanisms treatment. Subsequently, impacts PI3K/AKT axis, stress, mitochondria, assessed. In vitro, cultured (MC3T3-E1(14) cells exposed H2O2 examine signaling pathway, osteogenic differentiation, mitochondrial function, pyroptosis. Our findings demonstrated that Lut, similar control drug, effectively reduced systemic loss enhanced induced ovariectomy. indicated axis target, response nuclear membrane function being key mechanisms. Consequently, investigated. vivo data revealed deactivated following ovariectomy, restored phosphorylation proteins, thereby reactivating axis. Additionally, alleviated abnormalities intervention mitigated inhibition osteogenesis, well H2O2-induced Furthermore, attenuated ROS accumulation dysfunction. including osteogenesis restoration, anti-pyroptosis, maintenance, all reversed LY294002 (a pathway inhibitor). summary, could improve dysfunction, alleviate GSDME-mediated maintain via activating PI3K/Akt offering new therapeutic strategy for PMOP.

Language: Английский

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