International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(15), P. 8719 - 8719
Published: Aug. 5, 2022
CDKL5
deficiency
disorder
(CDD),
a
rare
and
severe
neurodevelopmental
disease
caused
by
mutations
in
the
X-linked
gene,
is
characterized
early-onset
epilepsy,
intellectual
disability,
autistic
features.
Although
pharmacotherapy
has
shown
promise
CDD
mouse
model,
safe
effective
clinical
treatments
are
still
far
off.
Recently,
we
found
increased
microglial
activation
brain
of
model
CDD,
Cdkl5
KO
mouse,
suggesting
that
neuroinflammatory
state,
known
to
be
involved
maturation
neuronal
dysfunctions,
may
contribute
pathophysiology
CDD.
The
present
study
aims
evaluate
possible
beneficial
effect
treatment
with
luteolin,
natural
flavonoid
have
anti-inflammatory
neuroprotective
activities,
on
development
behavior
heterozygous
(+/-)
female
best
resembles
genetic
condition.
We
inhibition
neuroinflammation
chronic
luteolin
ameliorates
motor
stereotypies,
hyperactive
profile
memory
ability
+/-
mice.
Luteolin
also
increases
hippocampal
neurogenesis
improves
dendritic
spine
arborization
cortical
neurons.
These
findings
show
microglia
overactivation
exerts
harmful
action
brain,
aimed
at
counteracting
process
should
considered
as
promising
adjuvant
therapy
for
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(3), P. 554 - 554
Published: Feb. 27, 2023
Cancer
is
a
global
concern,
as
the
rate
of
incidence
increasing
each
year.
The
challenges
related
to
current
chemotherapy
drugs,
such
concerns
toxicity,
turn
cancer
therapeutic
research
discover
alternative
therapy
strategies
that
are
less
toxic
normal
cells.
Among
those
studies,
use
flavonoids—natural
compounds
produced
by
plants
secondary
metabolites
for
therapy—has
been
hot
topic
in
treatment.
Luteolin,
flavonoid
has
present
many
fruits,
vegetables,
and
herbs,
identified
exhibit
numerous
biological
activities,
including
anti-inflammatory,
antidiabetic,
anticancer
properties.
property
Luteolin
extensively
researched
types
its
ability
inhibit
tumor
growth
targeting
cellular
processes
apoptosis,
angiogenesis,
migration,
cell
cycle
progression.
It
achieves
this
interacting
with
various
signaling
pathways
proteins.
In
review,
molecular
targets
it
exerts
properties,
combination
includes
other
flavonoids
or
chemotherapeutic
nanodelivery
described
several
types.
Metabolites,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1145 - 1145
Published: Nov. 20, 2022
Nature
gives
immense
resources
that
are
beneficial
to
humankind.
The
natural
compounds
present
in
plants
provide
primary
nutritional
values
our
diet.
Apart
from
food,
also
chemical
with
therapeutic
values.
importance
of
these
plant
secondary
metabolites
is
increasing
due
more
studies
revealing
their
properties
treating
and
managing
various
diseases
symptoms.
Among
them,
flavonoids
crucial
metabolite
most
plants.
Of
the
reported
8000
flavonoid
compounds,
luteolin
an
essential
dietary
compound.
This
review
discusses
source
its
biosynthesis.
Furthermore,
potential
health
benefits
luteolins
such
as
anti-cancer,
anti-microbial,
anti-inflammatory,
antioxidant,
anti-diabetic
effects
mechanisms
discussed
detail.
activity
derivatives
diverse,
they
help
prevent
control
many
life-threatening
effects.
will
enhance
knowledge
recent
findings
regarding
effects,
which
certainly
useful
potentially
utilizing
this
metabolite.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(7), P. 3417 - 3443
Published: April 26, 2024
Abstract
Natural
products
are
closely
associated
with
human
health.
Luteolin
(LUT),
a
flavonoid
polyphenolic
compound,
is
widely
found
in
fruits,
vegetables,
flowers,
and
herbs.
It
noteworthy
that
LUT
exhibits
variety
of
beneficial
pharmacological
properties
holds
significant
potential
for
clinical
applications,
particularly
antitumor,
anti‐convulsion,
diabetes
control,
anti‐inflammatory,
neuroprotection,
anti‐oxidation,
anti‐cardiovascular,
other
aspects.
The
mechanism
action
has
been
partially
elucidated,
including
the
mediation
NF‐κB,
toll‐like
receptor,
MAPK,
Wnt/β‐catenin,
PI3K/Akt,
AMPK/mTOR,
Nrf‐2,
among
others.
review
aimed
to
comprehensively
consolidate
essential
information
on
natural
sources,
effects,
therapeutic
preventive
potential,
as
well
mechanisms
LUT.
objective
establish
theoretical
basis
continued
development
application
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e26701 - e26701
Published: Feb. 20, 2024
Numerous
natural
products
found
in
our
diet,
such
as
polyphenols
and
flavonoids,
can
prevent
the
progression
of
cancer.
Luteolin,
a
flavone,
present
significant
amounts
various
fruits
vegetables
plays
key
role
chemopreventive
agent
treating
types
By
inducing
apoptosis,
initiating
cell
cycle
arrest,
decreasing
angiogenesis,
metastasis,
proliferation,
luteolin
is
used
to
treat
Its
anticancer
properties
are
attributed
its
capability
engage
with
multiple
molecular
targeted
sites
modify
signaling
pathways
tumor
cells.
Luteolin
has
been
shown
slow
spread
cancer
breast,
colorectal,
lung,
prostate,
liver,
skin,
pancreatic,
oral,
gastric
models.
It
exhibits
antioxidant
be
given
patients
receiving
Doxorubicin
(DOX)
chemotherapy
development
unexpected
adverse
reactions
lungs
hematopoietic
system
subjected
DOX.
Furthermore,
it
could
an
excellent
candidate
for
synergistic
studies
overcome
drug
resistance
Accordingly,
this
review
covers
recent
literature
related
use
against
different
cancer,
along
mechanisms
action.
In
addition,
highlights
complementary
medicine
preventing
Foods,
Journal Year:
2025,
Volume and Issue:
14(2), P. 260 - 260
Published: Jan. 15, 2025
This
study
explores
approaches
to
enhancing
the
biostability
of
extra
virgin
olive
oil
(EVOO)
supplemented
with
fruit
extract
(OFE)
enriched
hydroxytyrosol
(HTyr).
The
investigation
focuses
on
prolonged
deep
frying
(DF)
conditions
at
170
°C
and
210
°C,
over
durations
ranging
from
3
48
h,
aim
improving
sensorial
attributes,
polyphenolic
content,
thermal
oxidative
stability.
Parameters,
such
as
acidity,
peroxide
value
(PV),
K232,
K270,
ΔK,
phenolic
compounds,
sensory
were
monitored.
PV
did
not
exceed
standard
limit
in
HTyr-EVOO
°C/24
h;
however,
non-supplemented
EVOOs,
it
remained
within
limits
only
up
°C/18
h.
Acidity
stayed
acceptable
(≤0.8)
h
both
non-enriched
EVOOs.
K232
values
≤2.5
fried
K270
ΔK
°C/3
whereas
they
surpassed
them
oils.
Additionally,
HTyr
tyrosol
levels
significantly
higher
(p
<
0.05)
HTyr-EVOOs.
Phenolic
including
verbascoside,
pinoresinol,
1-acetoxypinoresinol,
acids,
chlorogenic,
vanillic,
homovanillic,
4-dihydroxybenzoic,
caffeic
detected
Oxidized
secoiridoid
derivatives
increased
DF
progressed.
Moreover,
analysis
revealed
that
positive
attributes
EVOOs—such
fruity,
bitter,
pungent
notes—decreased
increasing
temperature
duration
0.05).
Beyond
°C/6
these
rated
zero.
However,
HTyr-EVOOs
exhibited
lower
rancidity
compared
oils
under
identical
conditions,
attributed
protective
effect
HTyr.
In
conclusion,
demonstrated
stability
retaining
desirable
qualities,
reduced
degradation.
These
findings
indicate
natural
OFEs
have
strong
potential
food
additive
properties,
health
benefits,
overall
innovation
provides
a
practical
solution
for
industry
by
versatility
EVOO.
Further
research
is
recommended
investigate
various
EVOO
categories
diverse
origins.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(21), P. 5373 - 5373
Published: Oct. 31, 2022
Increasing
rates
of
cancer
incidence
and
the
toxicity
concerns
existing
chemotherapeutic
agents
have
intensified
research
to
explore
more
alternative
routes
combat
tumor.
Luteolin,
a
flavone
found
in
numerous
fruits,
vegetables,
herbs,
has
exhibited
number
biological
activities,
such
as
anticancer
anti-inflammatory.
Luteolin
inhibits
tumor
growth
by
targeting
cellular
processes
apoptosis,
cell-cycle
progression,
angiogenesis
migration.
Mechanistically,
luteolin
causes
cell
death
downregulating
Akt,
PLK-1,
cyclin-B1,
cyclin-A,
CDC-2,
CDK-2,
Bcl-2,
Bcl-xL,
while
upregulating
BAX,
caspase-3,
p21.
It
also
been
reported
inhibit
STAT3
signaling
suppression
activation
enhanced
protein
degradation
various
cells.
Therefore,
extensive
studies
on
properties
reveal
its
promising
role
chemoprevention.
The
present
review
describes
all
possible
interactions
cancer,
along
with
synergistic
mode
action
nanodelivery
insight.
Frontiers in Cardiovascular Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Jan. 23, 2023
Almost
20%
of
COVID-19
patients
have
a
history
atrial
fibrillation
(AF),
but
also
new-onset
AF
represents
frequent
complication
in
COVID-19.
Clinical
evidence
demonstrates
that
COVID-19,
by
promoting
the
evolution
prothrombotic
state,
increases
susceptibility
to
arrhythmic
events
during
infective
stages
and
presumably
post-recovery.
itself
is
most
form
arrhythmia
associated
with
substantial
morbidity
mortality.
One
molecular
factors
involved
COVID-19-related
episodes
angiotensin-converting
enzyme
(ACE)
2
availability.
Severe
acute
respiratory
syndrome
coronavirus
(SARS-CoV-2)
uses
ACE2
enter
infect
multiple
cells.
Atrial
internalization
after
binding
SARS-CoV-2
results
raise
angiotensin
(Ang)
II,
suppression
cardioprotective
Ang(1–7)
formation,
thereby
cardiac
hypertrophy,
fibrosis
oxidative
stress.
Furthermore,
several
pharmacological
agents
used
may
higher
risk
inducing
electrophysiological
changes
dysfunction.
Azithromycin,
lopinavir/ritonavir,
ibrutinib,
remdesivir,
treatment
predispose
an
increased
arrhythmia.
In
this
review,
putative
mechanisms
cardiovascular
safety
profile
drugs
for
are
summarized.
Phytomedicine,
Journal Year:
2023,
Volume and Issue:
116, P. 154865 - 154865
Published: May 9, 2023
Subretinal
fibrosis
(SF)
accounts
for
vision
loss
in
patients
with
neovascular
age-related
macular
degeneration
(nAMD)
even
treated
adequate
intravitreal
injection
of
anti-vascular
endothelial
growth
factor
(anti-VEGF)
drugs.
Currently,
there
is
no
treatment
available
to
prevent
or
treat
SF
caused
by
nAMD.This
study
aims
investigate
the
potential
effects
luteolin
on
and
epithelial-mesenchymal
transition
(EMT)
as
well
underlying
molecular
pathways
both
vivo
vitro.Seven-week-old
male
C57BL/6J
mice
were
employed
establish
laser-induced
choroidal
neovascularization
(CNV)
SF.
One
day
after
laser
induction,
was
administered
intravitreally.
CNV
assessed
immunolabeling
collagen
type
I
(collagen
I)
isolectin
B4
(IB4),
respectively.
RPE65
α-SMA
colocalization
lesions
used
evaluate
extent
EMT
retinal
pigment
epithelial
(RPE)
cells
using
immunofluorescence.
In
vitro,
TGFβ1-treated
primary
human
RPE
(phRPE)
cells.
RT-qPCR,
Western
blot
immunofluorescence
change
EMT-related
molecules,
markers,
relevant
signaling
pathways.
The
functional
changes
associated
investigated
scratch
assay,
Transwell
migration
gel
contraction
assay.
CCK-8
determine
cell
viability
phRPE
cells.On
7
14
induction
mice,
dramatically
decreased
immunolabeled
sizes
IB4,
amount
colocalized
double
immunostaining
lesions.
demonstrated
increased
capacity,
accompanied
considerable
overexpression
fibronectin,
α-SMA,
N-cadherin
vimentin,
downregulation
E-cadherin
ZO-1.
above
largely
inhibited
co-incubation.
Mechanistically,
could
evidently
decrease
phosphorylation
Smad2/3,
whereas
increase
YAP
cells.This
demonstrates
that
exhibits
anti-fibrotic
effect
a
mouse
model
inhibiting
via
deactivating
Smad2/3
signaling,
which
provides
natural
compound
prevention
fibrosis-related
diseases.
