Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Food & Function, Journal Year: 2023, Volume and Issue: 14(16), P. 7426 - 7438

Published: Jan. 1, 2023

Seabuckthorn flavonoids mitigated depressive behaviors, improved biochemical indexes and modulated the gut microbiota of CUMS-induced mice.

Language: Английский

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Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1486 - 1486

Published: Feb. 3, 2023

Alzheimer’s disease (AD) is an age-related chronic progressive neurodegenerative disease, which the main cause of dementia in elderly. Much evidence shows that onset and late symptoms AD are caused by multiple factors. Among them, aging factor pathogenesis AD, most important risk for neuroinflammation. So far, there no cure but relationship between neuroinflammation may provide a new strategy treatment AD. We herein discussed etiology hypothesis role as well anti-inflammatory natural products with potential to prevent alleviate symptoms, including alkaloids, steroids, terpenoids, flavonoids polyphenols, available great development anti-AD drugs.

Language: Английский

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Exploring the mechanism of luteolin by regulating microglia polarization based on network pharmacology and in vitro experiments

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 23, 2023

Abstract Neuroinflammation manifests following injury to the central nervous system (CNS) and M1/M2 polarization of microglia is closely associated with development this neuroinflammation. In study, multiple databases were used collect targets regarding luteolin polarization. After obtaining a common target, protein–protein interaction (PPI) network was created further analysis performed obtain core network. Molecular docking after gene enrichment analysis. vitro experiments examine expression related target proteins. A total 77 obtained, obtained by contained 38 GO KEGG analyses revealed that affects in regulation inflammatory response as well interleukin (IL)-17 tumor necrosis factor (TNF) signaling pathways. Through experiments, we confirmed use reduced inducible nitric oxide synthase (iNOS), IL-6, TNF-α, p-NFκBIA (p-IκB-α), p-NFκB p65, MMP9, while upregulating Arg-1 IL-10. This study reveals various potential mechanisms which induces M2 inhibit neuroinflammatory response.

Language: Английский

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Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive

Language: Английский

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Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols

Inflammopharmacology, Journal Year: 2021, Volume and Issue: 29(5), P. 1317 - 1329

Published: Aug. 4, 2021

Language: Английский

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