International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 288, P. 138698 - 138698
Published: Dec. 11, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1500 - 1500
Published: May 16, 2024
As the population ages, incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted importance gut microbial homeostasis its impact on brain functions, commonly referred as gut–brain axis, in maintaining overall health wellbeing. Nonetheless, mechanisms by which system acts remains poorly defined. In review, we will explore how (poly)phenols, a class natural compounds found many plant-based foods beverages, can modulate thereby promote neural health. While evidence indicates beneficial role (poly)phenol consumption part balanced diet, human scarce mechanistic insight still lacking. regard, make case that dietary (poly)phenols should be further explored establish their therapeutic efficacy through modulation with much greater emphasis carefully designed interventions.
Language: Английский
Citations
12
Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 133, P. 106371 - 106371
Published: June 1, 2024
Language: Английский
Citations
12
Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156490 - 156490
Published: Feb. 9, 2025
Language: Английский
Citations
1
Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 167 - 167
Published: March 1, 2025
Background: Gut microbiomes play a vital role in maintaining whole-body metabolic homeostasis. It has gained significant attention recent years due to advancements genome sequencing technologies and deeper understanding of its relationship with obesity. However, the specific ways which different microorganisms directly or indirectly influence host obesity, as well underlying mechanisms, remain uncertain because complexity gut microbiota composition. Methods: In this review, we summarize roles major phyla such Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia obesity type 2 diabetes based on studies published past five PubMed Google Scholar. The current therapeutic strategies associated are also explored from clinical trials, challenges future directions discussed. Results Conclusions: This review will provide functions diabetes, could lead more individualized effective treatments for diseases.
Language: Английский
Citations
1
Biology, Journal Year: 2023, Volume and Issue: 12(11), P. 1453 - 1453
Published: Nov. 20, 2023
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder impairing cognition and memory in the elderly. This has complex etiology, including senile plaque neurofibrillary tangle formation, neuroinflammation, oxidative stress, damaged neuroplasticity. Current treatment options are limited, so alternative treatments such as herbal medicine could suppress symptoms while slowing cognitive decline. We followed PRISMA guidelines to identify potential treatments, their associated medicinal phytochemicals, mechanisms of these treatments. Common herbs, Ginkgo biloba, Camellia sinensis, Glycyrrhiza uralensis, Cyperus rotundus, Buplerum falcatum, produced promising pre-clinical results. These herbs rich kaempferol quercetin, flavonoids with polyphenolic structure that facilitate multiple action. include inhibition Aβ reduction tau hyperphosphorylation, suppression modulation BDNF PI3K/AKT pathways. Using findings from quercetin research comparatively limited data on kaempferol, we proposed ameliorates neuroinflammatory state, maintains proper cellular function, restores pro-neuroplastic signaling. In this review, discuss anti-AD limitations, suggest for AD. Our lead us conclude polyherbal kaempferol- quercetin-rich cocktail treat AD-related brain damage.
Language: Английский
Citations
22
Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104965 - 104965
Published: Aug. 19, 2024
Language: Английский
Citations
6
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16
Published: Dec. 4, 2024
Flavonoids, a class of polyphenolic compounds, are widely distributed in plant-based foods and have been recognized for their potential to promote overall health well-being. Flavonoids fruits vegetables offer various beneficial effects such as anti-aging, anticancer, anti-inflammatory properties. extensively studied neuroprotective properties, which attributed ability cross the blood-brain barrier interact with neural cells. Factors like gut microbiota composition, age, genetics, diet can impact how well flavonoids absorbed gut. The enhance absorption through enzymatic processes, making composition key factor influenced by diet. modulate prebiotic antimicrobial effects, affecting production microbial metabolites short-chain fatty acids (SCFAs) butyrate, play role brain function health. microbiome also modulates immune system, is critical preventing neuroinflammation. Additionally, benefit mental psychological influencing signaling pathways cells increasing tyrosine tryptophan, precursors neurotransmitters serotonin, dopamine, norepinephrine, adrenaline, gamma-aminobutyric acid (GABA). flavonoid-gut axis complex multifaceted relationship that has significant implications neurological This review will explore genetic environmental factors flavonoid positive on network.
Language: Английский
Citations
5
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 21, 2024
Background The efficacy of Chinese herbal medicine (CHM) in managing irritable bowel syndrome with diarrhea (IBS-D) accompanied by anxiety and depression remains uncertain. Thus, a systematic review was carried out employing meta-analysis network pharmacology to ascertain the underlying mechanisms CHM therapy. Methods By conducting review, including literature search, screening, data extraction, we identified 25 randomized controlled trials assess CHM’s effectiveness treating alongside depression. Network utilized scrutinize metabolite utility addressing this condition. Potential primary were synthesized using information sourced from PubMed database. Results Twenty-five studies, 2055 patients, analyzed, revealing significant treatment for IBS-D trial group compared controls [OR = 4.01, 95% CI (2.99, 5.36), I 2 0%] Additionally, [SMD −1.08, (-1.30, −0.86), p < 0.00001, 68%; SDS: SMD -1.69, (-2.48, −0.90), 0.0001, 96%] [HAMA: -1.29, (-1.68, −0.91), 89%; SAS: -1.75, (-2.55, −0.95), significantly improved group. Furthermore, exhibited lower disease relapse rate 0.30, (0.20, 0.44), 0%]. consistently IBS severity (IBS-SSS) symptom scores. analysis key chemical metabolites traditional formulations, Beta-sitosterol, Stigmasterol, Quercetin, Naringenin, Luteolin, Kaempferol, Nobiletin, Wogonin, Formononetin, Isorhamnetin. Utilizing STRING database Cytoscape v3.9.0 software, protein-protein interaction (PPI) revealed top eight targets: IL-6, TNF, PPARG, PTGS2, ESR1, NOS3, MAPK8, AKT1, implicated anti-inflammatory responses, antioxidant stress modulation, neurotransmitter homeostasis maintenance. Conclusion Herbal Medicine offers promising safe approach patients dealing Diarrheal Irritable Bowel Syndrome depression; thus, indicating its potential practical implementation. most active could simultaneously act on pathological targets IBS-D, anxiety, depression.The diverse scope therapeutic role includes various aspects objectives, underscoring broad utilization.
Language: Английский
Citations
4
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Sea buckthorn (SB) offers remarkable health benefits through the synergistic actions of its bioactive compounds. High levels vitamin C, carotenoids and flavonoids enhance neurogenesis, reduce neuroinflammation support collagen synthesis. This synergy extends to gut health, fostering beneficial bacteria reducing oxidative stress. SB’s balanced profile essential fatty acids further amplifies bioavailability effectiveness fat-soluble vitamins. Omega-7, for example, works in concert with E promote skin regeneration damage, while omega-3 omega-6 modulate inflammatory responses antioxidant functions vitamins A E. Rich antioxidants like polyphenols lycopene, SB combats damage supports cardiovascular solidifying status as a functional superfood.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1027 - 1027
Published: March 14, 2025
Background: This study investigates the neuroprotective effects of 1,8-cineole (1,8-CH), against hippocampal oxidative stress in a chronic unpredictable mild (CUMS) mice model depression, focusing on underlying molecular mechanisms. Methods: The CUMS exposure were assessed by measuring markers, antioxidant activity, and neuronal damage hippocampus using histopathology, network pharmacology, Western blot analysis, small interfering RNA (siRNA) knockdown experiments. Results: 1,8-CH significantly alleviated depression-like behaviors mice. induced hippocampus, evidenced elevated MDA levels, decreased damage. DHE staining revealed ROS accumulation. Treatment with reducing MDA, restoring lowering while improving structure. Network pharmacology identified PI3K/Akt/Nrf2 pathway as key mediator 1,8-CH’s neuroprotection, which was supported results, demonstrating PI3K/Akt activation potential enhancement Nrf2 nuclear translocation. Furthermore, corticosterone-induced PC12 cells, abolished inhibition siRNA knockdown, confirming Nrf2’s role. Conclusions: These findings suggest that alleviates CUMS-induced depression via pathway, highlighting its health supplement for managing depression.
Language: Английский
Citations
0