Delivering the power of nanomedicine to patients today

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 326, P. 164 - 171

Published: July 15, 2020

The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified diagnostic technologies suitable for use in field and delivering targeted therapeutics. From our perspective nanotechnology is revealed as a vital resource this, generic platform technical tackle complex medical challenges. It towards this focusing on nanomedicine take issue with Prof Park's recent editorial published Journal Controlled Release. Prof. Park argued last 15 years failed deliver promised innovative patients (Park, K. beginning end hype. Release, 2019; 305, 221-222 [1]. We, ETPN (European Technology Platform Nanomedicine) [2], respectfully disagree. In fact, more than 50 formulations currently market, approval 3 key products (e. g. Onpattro, Hensify Vyxeos), have demonstrated concretely able design overcome critical barriers conventional medicine unique manner, but also within cells new drug-free therapeutic effects by using pure physical modes action, therefore make difference lives. Furthermore, >400 trials are expecting bring novel (e.g. platforms nucleic acid delivery), alone or combination other enabling biotechnologies, microfluidics, advanced materials, biomaterials, smart systems, photonics, robotics, textiles, Big Data ICT (information & communication technologies) generally. However, agree " it time examine sources difficulty translation move forward ". But reaching goal, investments support promising should increase, not decrease. As recently encouraged EMA its roadmap 2025, create unity through common knowledge hub linking academia, industry, healthcare providers hopefully policy makers reduce current fragmentation standardization regulatory body landscape. We promote strategy cross-technology innovation, development high value low-cost solution answer unmet help most projects get better faster clinic. This global vision one chose encourage fifteen years. All actions be taken clear view mind, without any fanfare", focus "on what matters real life", which patient his/her quality life. overview achievements serves reinforce drive further expanding growing maturity healthcare, accelerating pace transformation great potential into tangible breakthroughs.

Language: Английский

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Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(4), P. 282 - 300

Published: Jan. 19, 2023

Language: Английский

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Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(3), P. 3459 - 3636

Published: Jan. 7, 2022

Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, fast-responding sensors that are applicable biofluids (urine, blood, saliva). Particularly, metabolites, neurotransmitters, drugs, inorganic ions is highly desirable due to a lack suitable biosensors. In addition, monitoring analysis metabolic signaling networks cells organisms by optical probes chemosensors becoming increasingly important biology medicine. Thus, new perspectives personalized diagnostics, theranostics, biochemical/medical research will be unlocked when standing limitations artificial binders receptors overcome. this review, we survey synthetic sensing systems have promising (future) application detection small molecules, cations, anions aqueous media biofluids. Special attention was given provide readily measurable signal through dynamic covalent chemistry, supramolecular host-guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable reader evaluate current performance terms sensitivity selectivity respect practical requirement, thereby inspiring ideas further advanced systems.

Language: Английский

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Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

Advanced Science, Journal Year: 2021, Volume and Issue: 8(10)

Published: March 7, 2021

Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs their delivery efficacy the is severely hampered by presence of blood-brain barrier (BBB). Drug systems have been extensively explored in recent decades aiming circumvent this barrier. In particular, polymeric nanoparticles shown enormous potentials owing unique properties, high tunability, ease synthesis, control over drug release profile. However, careful analysis performance effective transport across BBB should be performed using clinically relevant testing models. review, nanoparticle for central nervous system discussed an emphasis on effects particle size, shape, surface modifications penetration. Moreover, authors critically analyze vitro vivo models used evaluate penetration efficacy, including latest developments BBB-on-a-chip Finally, challenges future perspectives development combat neurological discussed.

Language: Английский

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Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(13), P. 5365 - 5451

Published: Jan. 1, 2022

The present review details a chronological description of the events that took place during development mesoporous materials, their different synthetic routes and use as drug delivery systems. outstanding textural properties these materials quickly inspired translation to nanoscale dimension leading silica nanoparticles (MSNs). aspects introducing pharmaceutical agents into pores nanocarriers, together with possible biodistribution clearance routes, would be described here. smart nanocarriers are able release high local concentration therapeutic cargo on-demand after application certain stimuli reviewed here, ability deliver precise locations in body. huge progress design MSNs for biomedical applications, including potential treatment diseases, last 20 years will collated required work still needs done achieve clinical materials. This was conceived stand out from past reports since it aims tell story systems by some makers, who could considered among pioneers this area.

Language: Английский

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