ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(8), P. 7733 - 7749
Published: April 10, 2023
As
adjuvants
or
antigens,
bacterial
membranes
have
been
widely
used
in
recent
antibacterial
and
antitumor
research,
but
they
are
often
injected
multiple
times
to
achieve
therapeutic
outcomes,
with
limitations
biosafety
clinical
application.
Herein,
we
leverage
the
biocompatibility
immune
activation
capacity
of
Salmonella
strain
VNP20009
produce
double-layered
membrane
vesicles
(DMVs)
for
enhanced
systemic
safety
immunity.
Considering
photothermal
effect
polydopamine
upon
irradiation,
VNP20009-derived
DMVs
prepared
coat
surface
mesoporous
(MPD)
nanoparticles,
leading
potential
synergies
between
therapy
mediated
by
MPD
immunotherapy
magnified
DMVs.
The
single
dose
MPD@DMV
can
passively
target
tumors
activate
system
upregulated
T
cell
infiltration
secretion
levels
pro-inflammatory
factors
as
well
related
cytokines.
All
these
promoted
responses
result
malignant
melanoma
tumor
regression
extended
survival
time
on
local
distant
tumor-bearing
mouse
models.
Importantly,
further
explore
advantages
intravenous
injection
agent
compared
its
intratumoral
injection,
former
demonstrates
better
long-term
effects
animal
bodies.
Overall,
this
formulation
design
brings
broader
prospects
autologous
vaccine
adjuvant
cancer
therapy.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
21, P. 358 - 380
Published: Sept. 14, 2022
Nanomedicines
for
drug
delivery
and
imaging-guided
cancer
therapy
is
a
rapidly
growing
research
area.
The
unique
properties
of
nanomedicines
have
massive
potential
in
solving
longstanding
challenges
existing
drugs,
such
as
poor
localization
at
the
tumor
site,
high
doses
toxicity,
recurrence,
immune
response.
However,
inadequate
biocompatibility
restricts
their
clinical
translation.
Therefore,
advanced
nanomaterials
with
enhanced
therapeutic
efficiency
are
highly
desired
to
fast-track
translation
nanomedicines.
Intrinsic
nanoscale
covalent
organic
frameworks
(nCOFs),
suitable
size,
modular
pore
geometry
porosity,
straightforward
post-synthetic
modification
via
simple
transformations,
make
them
incredibly
attractive
future
ability
COFs
disintegrate
slightly
acidic
microenvironment
also
gives
competitive
advantage
targeted
delivery.
This
review
summarizes
recently
published
applications
delivery,
photo-immuno
therapy,
sonodynamic
photothermal
chemotherapy,
pyroptosis,
combination
therapy.
Herein
we
mainly
focused
on
modifications
enhance
biocompatibility,
efficacy
will
provide
fundamental
knowledge
designing
biocompatible
nCOFs-based
help
rapid
development
carriers
theranostics.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Plant Stress,
Journal Year:
2023,
Volume and Issue:
10, P. 100253 - 100253
Published: Oct. 10, 2023
The
world's
climate
shifts
rapidly,
leading
to
increasingly
severe
and
volatile
weather,
negatively
impacting
crop
yields.
To
produce
long-lasting
crops,
cutting-edge
nanotechnology
is
applied
agriculture
called
agri-nanotechnology
(ANT),
a
relatively
fresh
field
of
research.
ANT
aims
help
agricultural
systems
meet
the
demands
for
sustainable
food
production.
inclusion
could
transform
conventional
farming
practices
by
enabling
targeted
delivery
biomolecules
controlled
liberation
agrochemicals.
Increasing
yields
requires
vaster
understanding
interactions
between
plants
nanoparticles
(NPs)
make
them
more
resistant
environmental
stresses
maximize
their
utilization.
Furthermore,
well-known
highly
praised
tool
that
provides
various
solutions
build
modern
practices.
In
summation,
stands
as
vanguard
in
harnessing
nanoscale
innovations
optimize
protection
production
way.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(44)
Published: March 14, 2023
Proteins
and
enzymes
are
versatile
biomaterials
for
a
wide
range
of
medical
applications
due
to
their
high
specificity
receptors
substrates,
degradability,
low
toxicity,
overall
good
biocompatibility.
Protein
nanoparticles
formed
by
the
arrangement
several
native
or
modified
proteins
into
nanometer-sized
assemblies.
In
this
review,
we
will
focus
on
artificial
nanoparticle
systems,
where
main
structural
element
not
just
an
encapsulated
payload.
While
under
natural
conditions,
only
certain
form
defined
aggregates
nanoparticles,
chemical
modifications
change
in
physical
environment
can
further
extend
pool
available
building
blocks.
This
allows
assembly
many
globular
even
enzymes.
These
advances
preparation
methods
led
emergence
new
generations
nanosystems
that
beyond
transport
vehicles
diverse
applications,
from
multifunctional
drug
delivery
imaging,
nanocatalysis
protein
therapy.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(3)
Published: May 9, 2023
Cancer
is
one
of
the
fatal
diseases
in
history
humankind.
In
this
regard,
cancer
immunotherapeutic
strategies
have
revolutionized
traditional
mode
treatment.
Silica
based
nano-platforms
been
extensively
applied
nanomedicine
including
immunotherapy.
Mesoporous
silica
nanoparticles
(MSN)
and
mesoporous
organosilica
(MON)
are
attractive
candidates
due
to
ease
controlling
structural
parameters
as
needed
for
targeted
applications.
Especially,
MON
provide
an
additional
advantage
composition
modulating
biological
functions
actively
synergize
with
other
strategies.
review,
applications
MSN,
MON,
metal-doped
MSN/MON
field
immunotherapy
tumor
microenvironment
regulation
comprehensively
summarized
by
highlighting
compositional
attributes
silica-based
nanoplatforms.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(22), P. 7707 - 7736
Published: Jan. 1, 2023
This
review
summarizes
the
strategies
to
engineer
CDT
nanocatalysts
based
on
diverse
nanocarriers,
especially
those
with
intrinsic
therapeutic
activities.
