Advanced Engineering Materials,
Journal Year:
2024,
Volume and Issue:
26(21)
Published: Oct. 13, 2024
Advancements
in
polymers
have
made
significant
contribution
diverse
application‐oriented
fields.
The
multidisciplinary
application
of
generates
a
range
strategies,
which
is
applicable
wide
biomedicines.
Polymeric
compounds
such
as
hydrogels
been
explored
globally
potent
biomaterial
that
can
furnish
essential
attributes
due
to
their
three‐dimensional
(3D)
soft
and
highly
hydrophilic
polymeric
network.
These
used
extensively
various
applications
biocompatible,
biodegradable,
biosorption
nature.
However,
they
some
limitations,
owing
nature,
low
mechanical
properties,
unsatisfactory
degradation
profile.
Therefore,
there
need
develop
novel,
stronger,
more
durable
hybrid
with
enhanced
biocompatible
multifunctional
properties.
current
review
gives
broad
spectrum
its
importance
significance.
Further,
the
highlights
strategies
generation
reinforced
nanomaterials,
biomaterials,
nanobiocomposites
along
advantages
disadvantages.
also
features
these
field
biomedicines,
photocatalysis,
agriculture,
food
industry
over
last
5
years.
This
will
give
comprehensive
overview
researchers
working
development.
Journal of Applied Polymer Science,
Journal Year:
2022,
Volume and Issue:
140(4)
Published: Nov. 15, 2022
Abstract
There
has
been
significant
interest
in
the
recent
past
to
develop
injectable
hydrogel
scaffolds
that
follow
minimally
invasive
implantation
procedures
towards
efficient
healing
and
regeneration
of
defective
bone
tissues.
Such
offer
several
advantages,
as
they
can
be
injected
into
irregularly
shaped
defect
act
a
low‐density
aqueous
reservoir,
incorporating
necessary
components
for
tissue
repair
augmentation.
Considering
is
biocomposite
natural
biopolymer
bioapatite
nanofiller,
there
growing
trend
nanocomposite
by
combining
biopolymers
inorganic
nanofillers
biomimic
hierarchical
nanostructure
composition
bone.
Furthermore,
tailored
have
patient‐specific
properties,
which
lead
better
biological
responses.
The
present
article
begins
with
introduction,
followed
an
overview
polymer
matrices,
property
requirements,
crosslinking
techniques
employed
hydrogels.
Various
strategies
composites,
emphasis
on
hydrogels
bioinert
bioactive
discussed.
fundamental
challenges
related
development
research
efforts
directed
solving
these
problems
also
reviewed.
Finally,
future
trends
conclusions
new
generation
discussed
this
article.
International Journal of Polymeric Materials,
Journal Year:
2022,
Volume and Issue:
73(1), P. 1 - 32
Published: Sept. 13, 2022
Hydrogels
(HDG)
are
materials
exhibiting
versatile
applications
in
varying
fields
such
as
the
pharmaceutical
and
biomedical
industries.
However,
HDG
prone
to
inferior
chemical,
biological,
electrical
mechanical
features.
In
order
mitigate
these
deficiencies,
advent
of
nanotechnology
has
informed
inclusion
multifunctional
nanoparticulates
within
matrices
garnerior
superior
Thus,
polymeric
hydrogel
nanoarchitectures
(PHN)
amongst
emerging
category
new
nano-hydrogels,
fabricated
through
incorporation
nanoparticulates,
a
second
phase
HDG,
with
enhanced
enchanting
properties.
For
effective
applications,
prevalence
pores
PHN
is
outstanding
for
drug
delivery
systems
(DDS)
because
feasibility
conveying
active
entities
releasing
them
at
controlled
rate
mechanisms.
The
behavior
up-take
elevated
levels
water
transforms
immune-tolerant
nanomaterials
thereby
making
attractive
biologically
affiliated
especially
field
pharmacy
application.
Therefore,
this
paper
presents
recently
advancements
derivatives
including
macrogels
microgels,
nanogels.
Furthermore,
magnetically
responsive
"smart"
or
"intelligent"
DDS
also
presented.
They
preparation,
characterization,
properties
elaborately
elucidated
well.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(27), P. 34641 - 34655
Published: June 27, 2024
Skin
injuries
and
wounds
present
significant
clinical
challenges,
necessitating
the
development
of
advanced
wound
dressings
for
efficient
healing
tissue
regeneration.
In
this
context,
advancement
hydrogels
capable
counteracting
adverse
effects
arising
from
undesirable
reactive
oxygen
species
(ROS)
is
importance.
This
study
introduces
a
hybrid
hydrogel
with
rapid
photocuring
excellent
conformability,
tailored
to
ameliorate
hostile
microenvironment
damaged
skin
tissues.
The
hydrogel,
composed
photoresponsive
Gelatin
Methacryloyl
(GelMA)
Molybdenum-based
nanoclusters
(MNC),
exhibits
physicochemical
characteristics
conductive
vitro
studies
demonstrated
cytocompatibility
ROS-responsive
behavior
MNC/GelMA
hydrogels,
confirming
their
ability
promote
human
dermal
fibroblasts
(HDF)
functions.
incorporation
MNC
into
GelMA
not
only
enhances
HDF
adhesion,
proliferation,
migration
but
also
shields
against
oxidative
damage
induced
by
hydrogen
peroxide
(H2O2).
Notably,
in
vivo
evaluation
murine
full-thickness
defects
revealed
that
application
led
reduced
inflammation,
accelerated
closure,
enhanced
collagen
deposition
comparison
control
groups.
Significantly,
introduced
convenient
approach
develop
situ
ROS-scavenging
accelerate
process
without
need
exogenous
cytokines
or
medications.
We
consider
nanoengineering
proposed
herein
offers
potential
possibilities
therapeutic
addressing
various
skin-related
conditions.
Cell Biology and Toxicology,
Journal Year:
2024,
Volume and Issue:
40(1)
Published: Nov. 20, 2024
Gastric
cancer
(GC)
is
the
fifth
most
common
worldwide,
particularly
prevalent
in
Asia,
especially
China,
where
both
its
incidence
and
mortality
rates
are
significantly
high.
Meanwhile,
nanotechnology
has
demonstrated
great
potential
treatment
of
GC.
In
particular,
nanodrug
delivery
systems
have
improved
therapeutic
efficacy
targeting
through
various
functional
modifications,
such
as
peptides,
tumor
microenvironment
responsiveness,
instrument-based
methods.
For
instance,
silica
(SiO2)
excellent
biocompatibility
can
be
used
a
drug
carrier,
with
porous
structure
enhancing
loading
capacity.
Polymer
nanoparticles
regulate
release
mechanisms
by
altering
material
composition
preparation
Lipid
efficiently
encapsulate
hydrophilic
drugs
promote
cellular
uptake,
while
carbon-based
biosensors
delivery.
Targets
integrins,
HER2
receptors,
been
to
improve
GC
treatment.
Nanodrug
techniques
not
only
enhance
capabilities
but
also
selectively
target
cells.
Currently,
there
lack
systematic
summarization
synthesis
regarding
relationship
between
treatment,
which
some
extent
hinders
researchers
clinicians
from
searching
for
referencing
related
studies,
thereby
reducing
work
efficiency.
This
study
aims
systematically
summarize
existing
research
on
making
it
easier
professionals
search
reference,
promoting
further
role
their
clinical
applications
review
discusses
functionalized
nanocarriers
recent
years,
including
surface
modifications
targeted
markers,
combination
phototherapy,
chemotherapy,
immunotherapy,
along
advantages
challenges.
It
examines
future
prospects
nanomaterials
The
focuses
combined
application
multiple
modalities,
demonstrating
multimodal
treatments.
Furthermore,
thoroughly
explores
specific
challenges
that
face
biocompatibility,
control,
translation
issues,
providing
outlook
developments.
Additionally,
this
emphasizes
value
feasibility
applications,
contrasting
reviews
focus
basic
research.
Through
these
innovations,
we
offer
new
perspectives
directions
development
