NNT-AS1 in CAFs-derived exosomes promotes progression and glucose metabolism through miR-889-3p/HIF-1α in pancreatic adenocarcinoma DOI Creative Commons
Ping Zhang, Qun Wang, Weijun Lu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 24, 2024

Abstract It is metabolic and signaling crosstalk between stromal cells tumors in the tumor microenvironment, which influences several aspects of formation drug resistance, including reprogramming. Despite considerable findings linking lncRNAs HIF-1-related regulatory networks to cancer cell, little emphasis has been given role communication cancer-associated fibroblasts (CAFs) cells. Previously, we observed that NNT-AS1 was substantially expressed CAFs exosomes, subsequently investigated influence exosomal on glucose metabolism, proliferation, metastasis pancreatic ductal adenocarcinoma (PDAC) Transmission electron microscopy used examine exosomes secreted by PDAC patient-derived CAFs. qRT-PCR evaluate expression NNT-AS1, miR-889-3p, HIF-1. The CAFs-derived cell progression metabolism have identified. Dual luciferase reporter assays examined binding After co-culture CAFs, found they alter metastasis. In cells, CAF-derived lncRNA acted as a molecular sponge for miR-889-3p. Furthermore, HIF-1 could be targeted miR-889-3p controlled NNT-AS1. This study explores mechanism interaction glycolytic remodeling, through regulating miR-889-3p/HIF-1α, also helps discover new clinical treatment targets PDAC.

Language: Английский

Circulating miRNAs and lncRNAs serve as biomarkers for early colorectal cancer diagnosis DOI
Ehsan Lotfi,

Azam Kholghi,

Fereshteh Golab

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155187 - 155187

Published: Feb. 7, 2024

Language: Английский

Citations

11
Wnt/β-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target DOI Creative Commons

Zekun Zhao,

Tenglu Cui,

Fengxian Wei

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 2, 2024

Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and one of leading causes cancer-related deaths worldwide. The Wnt/β-Catenin signaling pathway a highly conserved involved in several biological processes, including improper regulation that leads to tumorigenesis progression cancer. New studies have found abnormal activation major cause HCC tumorigenesis, progression, resistance therapy. perspectives approaches treating will arise from understanding this pathway. This article offers thorough analysis pathway’s function its therapeutic implications HCC.

Language: Английский

Citations

11
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications DOI Creative Commons

Shiliang Xu,

Lingxia Wang,

Yuexin Zhao

et al.

Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 31(1)

Published: Feb. 26, 2024

Abstract Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming energy metabolism major feature malignant transformation breast cancer. Compared normal cells, tumor cells reprogram metabolic processes more efficiently, converting nutrient supplies into glucose, amino acid and lipid required for proliferation progression. Non-coding RNAs(ncRNAs) are class functional RNA molecules not translated proteins but regulate expression target genes. NcRNAs have been demonstrated be involved in various aspects metabolism, including glycolysis, glutaminolysis, fatty synthesis. This review focuses on regulatory mechanisms clinical applications metabolism-regulating ncRNAs We summarize vital roles played by endocrine therapy, targeted chemotherapy, immunotherapy, radiotherapy resistance cancer, as well their potential therapeutic targets biomarkers. Difficulties perspectives current non-coding strategies discussed.

Language: Английский

Citations

10
The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy DOI
Peng Huang,

Feng Wen,

YiShan Li

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 344, P. 122576 - 122576

Published: March 14, 2024

Language: Английский

Citations

9
NNT-AS1 in CAFs-derived exosomes promotes progression and glucose metabolism through miR-889-3p/HIF-1α in pancreatic adenocarcinoma DOI Creative Commons
Ping Zhang, Qun Wang, Weijun Lu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 24, 2024

Abstract It is metabolic and signaling crosstalk between stromal cells tumors in the tumor microenvironment, which influences several aspects of formation drug resistance, including reprogramming. Despite considerable findings linking lncRNAs HIF-1-related regulatory networks to cancer cell, little emphasis has been given role communication cancer-associated fibroblasts (CAFs) cells. Previously, we observed that NNT-AS1 was substantially expressed CAFs exosomes, subsequently investigated influence exosomal on glucose metabolism, proliferation, metastasis pancreatic ductal adenocarcinoma (PDAC) Transmission electron microscopy used examine exosomes secreted by PDAC patient-derived CAFs. qRT-PCR evaluate expression NNT-AS1, miR-889-3p, HIF-1. The CAFs-derived cell progression metabolism have identified. Dual luciferase reporter assays examined binding After co-culture CAFs, found they alter metastasis. In cells, CAF-derived lncRNA acted as a molecular sponge for miR-889-3p. Furthermore, HIF-1 could be targeted miR-889-3p controlled NNT-AS1. This study explores mechanism interaction glycolytic remodeling, through regulating miR-889-3p/HIF-1α, also helps discover new clinical treatment targets PDAC.

Language: Английский

Citations

9