Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 27, 2024
Language: Английский
Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Cancer-associated fibroblasts (CAFs) constitute a critical component of the tumor microenvironment (TME). CAFs can be reprogrammed by cancer cells, leading to production extracellular vesicles (EVs). These EVs serve as carriers for bioactive substances, including proteins, nucleic acids, and metabolic products, thereby facilitating progression. CAF-derived exert substantial influence on cell proliferation, invasion, metastasis, immunological environment, processes lymphangiogenesis angiogenesis. Despite their potential non-invasive biomarkers therapeutic delivery vehicles, clinical application is currently limited challenges in purification precise targeting. This review delineates diverse roles growth, immune evasion within TME.
Language: Английский
Citations
3
Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(13), P. 14468 - 14483
Published: May 15, 2023
Abstract Background Esophageal squamous cell carcinoma (ESCC), an aggressive gastrointestinal tumor, often has high early lymphatic metastatic potential. Cancer‐associated fibroblasts (CAFs) are primary components in tumor microenvironment (TME), and the impact of CAFs its derived exosomes on lymphangiogenesis remains elusive. Materials Methods microlymphatic vessel density (MLVD) ESCC was examined. Exosomes were extracted from normal fibroblast (NFs) CAFs. Subsequently, tumor‐associated endothelial cells (TLECs) treated with these exosomes, effect their biological behavior miR‐100‐5p selected as target miRNA, TLECs The predicted confirmed. IGF1R, PI3K, AKT, p‐AKT expression tumors Results A large number vessels present ESCC, leading to a poor prognosis. CAF‐derived promoted proliferation, migration, invasion, tube formation TLECs. Further, they also enhanced xenografts. levels significantly lower than NF‐derived exosomes. inhibited Mechanistic studies revealed that this inhibition mediated by miR‐100‐5p‐induced IGF1R/PI3K/AKT axis. Conclusion Taken together, our study demonstrates decreased exhibit pro‐lymphangiogenesis capacity, suggesting possibility targeting axis strategy inhibit metastasis ESCC.
Language: Английский
Citations
23
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: April 17, 2024
Cancer-associated fibroblasts (CAFs), a class of stromal cells in the tumor microenvironment (TME), play key role controlling cancer cell invasion and metastasis, immune evasion, angiogenesis, resistance to chemotherapy. CAFs mediate their activities by secreting soluble chemicals, releasing exosomes, altering extracellular matrix (ECM). Exosomes contain various biomolecules, such as nucleic acids, lipids, proteins. microRNA (miRNA), 22–26 nucleotide non-coding RNA, can regulate cellular transcription processes. Studies have shown that miRNA-loaded exosomes secreted engage regulatory communication networks with other TME constituents. This study focused on roles CAF-derived exosomal miRNAs generating malignant characteristics, including modulation, growth, migration invasion, epithelial-mesenchymal transition (EMT), treatment resistance. thoroughly examines miRNA’s dual promoting suppressing cancer. Thus, changes be used biomarkers for diagnosis prognosis patients, specificity develop newer therapies. review also discusses pressing problems require immediate attention, aiming inspire researchers explore more novel avenues this field.
Language: Английский
Citations
9
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189264 - 189264
Published: Jan. 1, 2025
Language: Английский
Citations
1
PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19188 - e19188
Published: March 27, 2025
MicroRNAs (miRNAs) are a class of non-coding RNA sequences that regulate gene expression post-transcriptionally. The miR-99 family, which is highly evolutionarily conserved, comprises three homologs: miR-99a, miR-99b, and miR-100. Its members under-expressed in most cancerous tissues, suggesting their cancer-repressing properties multiple cancers; however, some contexts, they also promote malignant lesion progression. MiR-99 family target numerous genes involved various tumor-related processes such as tumorigenesis, proliferation, cell-cycle regulation, apoptosis, invasion, metastasis. We review the recent research on this summarize its implications cancer, explore potential biomarker cancer therapeutic target. This contributes to clinical translation members.
Language: Английский
Citations
1
BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 1, 2025
MicroRNAs (miRNAs) play a key role in regulating gene expression within the tumor microenvironment, influencing cancer progression and therapy response. Cancer-associated fibroblasts (CAFs) contribute to development by secreting exosomal miRNAs that promote proliferation, invasion, resistance. This systematic review evaluates impact of CAF-derived on head neck malignancies. A search was conducted PubMed, Scopus, WOS, Google Scholar following PRISMA guidelines. Studies focusing cancers were included. Data extraction covered study characteristics, miRNA profiling methods, functional roles, clinical significance. The Scirap tool used for quality assessment. Among 921 identified articles, 21 met inclusion criteria. Findings indicate miR-21-5p, miR-106-5p, miR-196a drive oral squamous cell carcinoma (OSCC), while miR-124 miR-34a-5p act as suppressors. In esophageal (ESCC), miR-21 miR-27a/b chemotherapy resistance, whereas miR-100-5p inhibits lymphangiogenesis. (HNSCC), miR-196b may serve diagnostic biomarkers. Exosomal miR-106a-5p promotes nasopharyngeal (NPC) metastasis, miR-7 resistance (HNC). significantly influence progression, These findings highlight their potential biomarkers therapeutic targets, warranting further research personalized treatment strategies.
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 23, 2024
Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, lipids can serve as messengers for intercellular communication. They play critical roles in the exchange information between tumor cells microenvironment (TME). The TME consists mesenchymal components extracellular matrix (ECM), fibroblasts being most abundant cell type mesenchyme. Cancer-associated (CAFs) derived from normal stem that activated TME. CAFs secrete exosomes to modulate proliferation, invasion, migration, drug resistance, other biological processes tumors. Additionally, manipulate function behavior through direct cell-cell interactions. This review provides summary crosstalk GI exosomes, along potential underlying mechanisms.
Language: Английский
Citations
8
Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 17(5), P. 687 - 695
Published: Jan. 1, 2024
Review of how fibroblasts affect esophageal cancer (squamous cell carcinoma and adenocarcinoma) progression including their role
Language: Английский
Citations
5
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 22, 2024
Abstract Background Extracellular vesicles (EVs) have been revealed to facilitate the development of oral squamous cavity cell carcinoma (OCSCC), while its supporting role in lymph node metastases is under continuous investigation. This study aimed examine function cancer-associated fibroblasts (CAF)-derived EVs (CAF-EVs) during metastasis OCSCC and mechanisms. Methods CAF were isolated from tissues patients, CAF-EVs extracted identified. EdU, colony formation, wound healing, Transwell assays performed. The cells before after treatment injected into mice probe effects on tumor growth metastasis, respectively. effect transcriptome changes was analyzed. Clinical data patients with analyzed determine prognostic significance selected genes. Finally, loss-of-function conducted corroborate involvement polycomb complex protein BMI-1 (BMI1) integrin beta1 (ITGB1). Results promoted malignant behavior accelerated mice. significantly increased expression BMI1 ITGB1, ITGB1 negatively correlated overall survival relapse-free patients. Knockdown or abated promoting vitro vivo. Conclusion elicited metastasis-promoting properties by elevating suggesting that could be potential biomarkers therapeutic targets for OCSCC.
Language: Английский
Citations
5
Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111631 - 111631
Published: Jan. 1, 2025
Language: Английский
Citations
0