BioMed Research International,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 13
Published: Oct. 12, 2023
Introduction.
Candida
auris
is
a
relatively
novel
pathogen
first
described
in
2009
Japan.
It
has
increased
its
presence
worldwide,
becoming
public
health
concern
due
to
innate
resistance
antifungals
and
outbreak
potential.
Methods.
We
performed
query
using
the
word
“Candida
auris”
from
Scopus
database,
further
performing
bibliometric
analysis
with
open-source
R
package
Bibliometrix.
Results.
907
original
articles
were
retrieved,
allowing
us
map
principal
authors,
papers,
journals,
countries
involved
this
yeast
research,
as
well
analyze
current
future
trends
number
of
published
articles.
Conclusion.
C.
will
continue
be
pivotal
point
fungal
either
for
better
understanding
pathogenic
mechanisms
or
developing
drugs.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(9)
Published: July 2, 2024
Diabetes
mellitus
is
a
chronic
and
most
prevalent
metabolic
disorder
affecting
422
million
the
people
worldwide
causing
life-threatening
associated
conditions
including
disorders
of
kidney,
heart,
nervous
system
as
well
leg
amputation
retinopathy.
Steadily
rising
cases
from
last
few
decades
suggest
failure
currently
available
drugs
in
containment
this
disease.
α-Glucosidase
potential
target
for
effectively
tackling
disease
attracting
significant
interest
medicinal
chemists
around
globe.
Besides
having
set
side
effects,
α-glucosidase
inhibitors
(carbohydrate
mimics)
offer
better
tolerability,
safety,
synergistic
pharmacological
outcomes
with
other
antidiabetic
therefore
have
working
extensively
over
three
developing
alternative
inhibitors.
The
1,2,3-Triazole
nucleus
energetically
used
by
various
research
groups
globe
development
posing
it
an
optimum
scaffold
field
drug
development.
This
review
systematic
analysis
developed
employing
1,2,3-triazole
special
focus
on
design
strategies,
structure-activity
relationships,
mechanism
inhibitory
effect.
article
will
act
lantern
potent,
safer,
effective
desired
properties
improved
therapeutic
efficacy.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101406 - 101406
Published: Jan. 1, 2024
Candida
species
have
long
been
attributed
to
various
diseases
like
candidiasis
and
systemic
exacerbate
the
symptoms
of
immunocompromised
patients.
enzymes
that
could
function
as
drug
targets
decrease
their
pathogenicity
eradicate
fungi.
This
research
aimed
investigate
potency
new
bis-triazolothiadiazine
derivatives
contained
in
inhibiting
important
C.
albicans
an
example,
through
molecular
docking
simulation.
Thus,
a
novel
series
bis-triazolo[3,4-b][1,3,4]thiadiazines
were
designed
prepared
via
reaction
most
versatile,
hitherto
unreported
5,5′-(1,2,2-trimethylcyclopentane-1,3-diyl)bis(4-amino-2,4-dihydro-3H-1,2,4-triazole-3-thione)
with
appropriate
hydrazonoyl
halides
phenacyl
bromides.
Various
spectroscopic
techniques
used
identify
structures
synthesized
derivatives.
The
tested
against
different
spp.
effective
compound
was
6f
followed
by
6b,
6d,
6e,
where
inhibition
zone
ranged
from
45
mm
38
mm.
By
using
docking,
which
highlighted
interactions
amino
acid
residues
Lys57,
Leu77,
Glu116,
Gly114,
Phe36,
Thr58,
Glu32
at
point
binding,
it
possible
determine
binding
produced
fluconazole
target
interaction
energy
discovered
be
−6.494
kcal/mol
for
fungi
candida
(PDB
ID:
1IA2).
demonstrated
highest
efficacy,
displayed
significant
conserved
site
fungi,
conjunction
PDB
co-crystal
ligand
1IA2.
study's
results
also
revealed
dG
scores
bis-triazolo-thiadiazines
6b-f.
study
shows
good
acceptable
interactions.
Finally,
studies
lowest
activity
6e
6c
Tropical Medicine and Infectious Disease,
Journal Year:
2025,
Volume and Issue:
10(5), P. 142 - 142
Published: May 20, 2025
Parasitic
diseases
represent
a
severe
global
burden,
with
current
treatments
often
limited
by
toxicity,
drug
resistance,
and
suboptimal
efficacy
in
chronic
infections.
This
review
examines
the
emerging
role
of
triazole-based
compounds,
originally
developed
as
antifungals,
advanced
antiparasitic
therapy.
Their
unique
structural
properties,
particularly
those
1,2,3-
1,2,4-triazole
isomers,
facilitate
diverse
binding
interactions
favorable
pharmacokinetics.
By
leveraging
innovative
synthetic
approaches,
such
click
chemistry
(copper-catalyzed
azide–alkyne
cycloaddition)
structure-based
design,
researchers
have
repurposed
optimized
triazole
scaffolds
to
target
essential
parasite
pathways,
including
sterol
biosynthesis
via
CYP51
other
novel
enzymatic
routes.
Preclinical
studies
models
Chagas
disease,
leishmaniasis,
malaria,
helminth
infections
demonstrate
that
derivatives
like
posaconazole,
ravuconazole,
DSM265
exhibit
potent
vitro
vivo
activity,
although
their
primarily
static
effects
success
monotherapies
cases.
Combination
strategies
hybrid
molecules
demonstrated
potential
enhance
mitigate
resistance.
Despite
challenges
achieving
complete
clearance
managing
interdisciplinary
efforts
across
medicinal
chemistry,
parasitology,
clinical
research
highlight
significant
triazoles
components
next-generation,
patient-friendly
regimens.
These
findings
support
further
optimization
evaluation
agents
improve
for
neglected
parasitic
diseases.
Egyptian Pharmaceutical Journal,
Journal Year:
2024,
Volume and Issue:
23(2), P. 157 - 183
Published: Feb. 22, 2024
1,2,3-Triazole
is
considered
to
be
the
lead
structure
for
discovery
of
many
drug
molecules.
has
received
considerable
attention
in
field
due
its
remarkable
widespread
biological
potential.
This
work
summarizes
current
synthetic
pathways
adopted
synthesis
diverse
analogs
1,2,3-triazole.
It
also
introduces
an
overview
latest
advances
1,2,3-triazole
hybrid
models
with
various
pharmacological
activities,
their
chemical
structures,
structure–activity
relationships,
and
mechanisms
action.
PeerJ Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
6, P. e10 - e10
Published: July 25, 2024
Invasive
fungal
infections
are
increasing
worldwide
due
to
an
expanding
number
of
immunocompromised
patients
as
well
increase
in
drug-resistant
fungi.
While
resistance
has
increased,
this
not
been
accompanied
by
the
development
new
antifungals.
A
common
class
antifungal
agents
that
prescribed
azoles,
which
contain
either
a
triazole
or
imidazole
group.
Unfortunately,
current
like
fluconazole,
have
shown
be
less
effective
with
resistant
pathogens.
Therefore,
novel
azole
compounds
is
urgent
need.
The
objective
research
was
synthesize
triazole-containing
small
molecules
potent
activity.
scaffold
synthesized
contains
moiety
and
via
copper-catalyzed
azide-alkyne
click
reaction
(CuAAC)
between
appropriate
alkyne
azide
intermediates.
minimum
inhibitory
concentrations
these
were
determined
using
standard
broth
microdilution
assays
against
opportunistic
bacteria
fungi
associated
life-threatening
invasive
infections.
Although
possessed
no
antimicrobial
activity,
results
can
used
further
long-term
goal
developing
optimizing
lead
vitro
