Riding the metal wave: A review of the latest developments in metal-based anticancer agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215579 - 215579

Published: Nov. 28, 2023

Language: Английский

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Manganese(II) complexes of thiophenyl imino-ligand with synergistic behavior in biological systems, ct-DNA interactions, and catalytic oxidative performance of benzyl alcohol

Polyhedron, Journal Year: 2025, Volume and Issue: unknown, P. 117441 - 117441

Published: Feb. 1, 2025

Language: Английский

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Biological and Catalytic Evaluation for Nickel (II) and Oxyvanadium (II) Chelates of tri‐Dentate Hydrazone‐Quinoxalyl Ligand

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 25, 2025

ABSTRACT Formation of a tridentate mono‐basic hydrazone‐quinoxalyl ligand was done through condensation quinoxalyl‐2‐carbohydrazide with 2‐hydroxy‐1‐naphthaldehyde (H 2 dip). The coordination capability H dip Ni (II) and V (IV) ions examined at molar ratios 1:1 leading to the synthesis two distinct complexes, Ni(dip) VO(dip), respectively. chemical structure validated by many spectroscopic techniques. characterization included carbon, hydrogen, nitrogen elemental analyses assessments magnetic properties conductivity behavior. inhibited effects (organic molecules) its chelating agents on constrained proliferation three specific bacterial/fungal types, beside established human cancer cell lines, have been evaluated in relation structural impact VO(dip) compared their free research aimed determine nature influence metal chelates binding affinity dip, Ni(dip), for ct‐DNA, that is, calf thymus DNA, depending viscometric/spectrophotometric alterations characters. Furthermore, assessment constants (13.12, 15.19, 14.88 × 10 7 mol −1 dm 3 ), Gibbs energy (−40.21, −44.51, −45.01 kJ chromism modes respectively, used examine interaction mechanisms attributing increased ct‐DNA comparison dip. antioxidant potential within SOD (superoxide dismutase) DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) assays, reporting respectable reactivity. catalysts represented superior catalytic oxidative activity 1,2‐cyclooctene (unsaturated hydrocarbons, CyO) using hydrogen peroxide homogenous manner. At 80°C, yield percentage selective epoxy‐cyclooctane (CyOO) 90% after h 93% acetonitrile (the best solvent) disparity optimum actions these pertained differences electronegativity Lewis's acidity, suggested mechanistic pathway.

Language: Английский

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Harnessing the power of gold: advancements in anticancer gold complexes and their functionalized nanoparticles

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(3), P. 552 - 576

Published: Dec. 11, 2023

Captivating anticancer properties of gold complexes and functionalized nanoparticles.

Language: Английский

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Dioxomolybdenum(VI) and oxovanadium(IV) organo-complexes of tartrato-dihydrazone ligand as reactive antitumor and antimicrobial agents. ctDNA interactive nature

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 407, P. 125161 - 125161

Published: May 31, 2024

Language: Английский

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Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1729 - 1729

Published: Dec. 15, 2023

Poor responses to medical care and the failure of pharmacological treatment for many high-frequency diseases, such as cancer viral infections, have been widely documented. In this context, numerous metal-based substances, including cisplatin, auranofin, various gold metallodrugs, ruthenium complexes, are under study possible anticancer antiviral agents. The two Ru(III) Ru(II) namely, BOLD-100 RAPTA-C, presently being studied in a clinical trial preclinical studies evaluation, respectively, Interestingly, has also recently demonstrated activity against SARS-CoV-2, which is virus responsible COVID-19 pandemic. Over last years, much effort dedicated discovering new dual anticancer-antiviral Ru-based complexes could be very suitable respect. Thus, review focuses on most recent regarding newly synthesized use and/or

Language: Английский

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Coordinated metal complexes with curcumin Schiff base: Synthesis, investigation, antibacterial screening, antioxidant studies, molecular docking and density function theory calculations

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(3)

Published: Jan. 7, 2024

Condensation of curcumin with furfuryl amine led to the synthesis H 2 L Schiff base in a 1:1 Molar ratio. Subsequently, complexes this several transition metal ions were prepared also one‐to‐one molar Multiple characterization techniques employed identify structure all compounds. Infrared, UV, proton magnetic resonance spectroscopic tests, elemental analysis, mass spectrometry, thermal conductivity, and density function theory (DFT) calculations utilized gain comprehensive understanding their structures. Except for nickel (II) complex, which exhibits non‐electrolyte behavior, found exhibit electrolytic behavior based on conductivity studies. Additionally, thermogravimetric analysis was learn more about complexes' breakdown ligand's behavior. From DFT studies, some parameters obtained as bond angles lengths, chemical hardness, softness, energy levels highest occupied molecular orbital lowest unoccupied orbital, electrophilic index, dipole moment, electronegativity, other variables. Against one or bacterial species, it discovered that antibacterial activity superior free base. Furthermore, exhibited notable antioxidant according results using DPPH scavenging. Overall, detailed synthesized compounds performed, revealing structural features, functional properties, potential applications. Lastly, research docking investigated toward against 3C1L protein receptor.

Language: Английский

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Can Mn coordination compounds be good candidates for medical applications?

Frontiers in Chemical Biology, Journal Year: 2024, Volume and Issue: 3

Published: Jan. 31, 2024

Metal centres provide unique foci for varied biological modes of action that often but not exclusively involve redox or metal-ligand reactions. complexes offer alternative and flexible coordination geometries, electron proton transfer sites, inner outer sphere reactivities, sites redox-active, hemi-labile, non-innocent ligands, a variety potentially controllable properties exploitation in therapeutic context. The discovery the first anticancer, metal-based compound cisplatin 1965 by Barnett Rosenberg was historical outstanding breakthrough led to new area metal-drug discovery. Some compounds have FDA approval clinical use, while some undergo trials various medical therapies. This mini-review focuses on recent progress Mn-based with potential antibacterial, antifungal activities.

Language: Английский

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(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 420 - 420

Published: March 30, 2024

The (pentamethylcyclopentadienyl)chloridoiridium(III) complex bearing a κP,κS-bonded Ph2PCH2CH2SPh ligand ([Ir(η5-C5Me5)Cl(Ph2P(CH2)2SPh-κP,κS)]PF6, (1)] was synthesized and characterized. Multinuclear (1H, 13C 31P) NMR spectroscopy employed for the determination of structure. Moreover, SC-XRD confirmed proposed structure belongs to “piano stool” type. Hirshfeld surface analysis outlined most important intermolecular interactions in crystallographic optimized at B3LYP-D3BJ/6-311++G(d,p)(H,C,P,S,Cl)/LanL2DZ(Ir) level theory. applicability this verified through comparison experimental theoretical bond lengths angles, 1H chemical shifts. Natural Bond Orbital theory used identify quantify intramolecular stabilization interactions, especially those between donor atoms Ir(III) ions. Complex 1 tested on antitumor activity against five human tumor cell lines: MCF-7 breast adenocarcinoma, SW480 colon 518A2 melanoma, 8505C thyroid carcinoma A253 submandibular carcinoma. showed superior cisplatin-resistant MCF-7, lines. mechanism tumoricidal action cells indicates involvement caspase-induced apoptosis, accompanied by considerable reduction ROS/RNS proliferation potential treated cells.

Language: Английский

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Applications of Biodegradable Polymers in the Encapsulation of Anticancer Metal Complexes

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: May 7, 2024

Abstract Metal complexes have recently attracted a lot of attention, particularly as anticancer and antibacterial agents, owing to their versatile mechanisms easily tunable characteristics. However, the application such compounds in medical context, especially cancer treatment, has been hampered due limited solubility stability water aqueous solutions, well lack selectivity. To address these limitations, several approaches developed improve targeted delivery solubility. The first strategy involves physical encapsulation metal within carriers facilitate controlled drug release. second covalently linking polymers, creating prodrugs that can be converted active drugs at more controllable rate. Despite increasing variety polymers available, need develop those able metabolized by body, producing non‐toxic residues, remains crucial for effective area diseases cancer. In this perspective article, an overview recent developments using biodegradable therapy is provided. It specifically highlighting how formed nanoparticles (NPs) enhance selectivity toxicity toward cells compared parent complex, while simultaneously reducing harmful side effects traditional chemotherapies, opening door them combination therapies (PDT, PTT).

Language: Английский

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