Where Chemocatalysis Meets Biocatalysis: In Water

Chemical Reviews, Journal Year: 2022, Volume and Issue: 123(9), P. 5262 - 5296

Published: Dec. 6, 2022

Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major challenge, solution to which, however, is associated with numerous advantages, run such one-pot processes water: majority enzyme-catalyzed take place water as Nature's medium, thus enabling broad synthetic diversity when due option use virtually all types enzymes. Furthermore, cheap, abundantly available, environmentally friendly, making it, principle, an ideal medium. On other hand, most routinely performed today organic solvents (which might deactivate enzymes), appearing make it difficult combine biocatalysis toward cascades water. Several creative approaches solutions that enable combinations chemo- be realized applied problems are presented herein, reflecting state-of-the-art this blossoming field. Coverage has been sectioned into three parts, after introductory remarks: (1) Chapter 2 focuses on historical developments initiated area research; (2) 3 describes key post-initial discoveries have advanced field; (3) 4 highlights latest achievements provide attractive main question compatibility between (used predominantly aqueous media) (that remains solvents), Chapters covering mainly literature from ca. 2018 present. 5 6 brief overview where field stands, challenges lie ahead, ultimately, prognosis looking future chemoenzymatic catalysis synthesis.

Language: Английский

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Palladium-catalyzed micellar cross-couplings: An outlook

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 488, P. 215158 - 215158

Published: May 2, 2023

Language: Английский

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Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Chemical Communications, Journal Year: 2021, Volume and Issue: 57(89), P. 11847 - 11850

Published: Jan. 1, 2021

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis water can be greatly enhanced by the presence of nanomicelles derived from surfactant TPGS-750-M. Transformations are provided that illustrate variety sequences now possible 1-pot as representative examples this environmentally attractive approach to organic synthesis.

Language: Английский

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Is Micellar Catalysis Green Chemistry?

Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4809 - 4809

Published: June 16, 2023

Many years ago, twelve principles were defined for carrying out chemical reactions and processes from a green chemistry perspective. It is everyone’s endeavor to take these points into account as far possible when developing new or improving existing ones. Especially in the field of organic synthesis, area research has thus been established: micellar catalysis. This review article addresses question whether catalysis by applying reaction media. The shows that many can be transferred an solvent medium, but surfactant also crucial role solubilizer. Thus, carried much more environmentally friendly manner with less risk. Moreover, surfactants are being reformulated their design, degradation add extra advantages match all chemistry.

Language: Английский

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“TPG-lite”: A new, simplified “designer” surfactant for general use in synthesis under micellar catalysis conditions in recyclable water

Tetrahedron, Journal Year: 2021, Volume and Issue: 87, P. 132090 - 132090

Published: March 27, 2021

Language: Английский

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Illuminating a Path4914. Copyright 2016 Wiley for Organic Synthesis Towards Sustainability. No One Said It Would Be Easy…

Synlett, Journal Year: 2021, Volume and Issue: 32(16), P. 1588 - 1605

Published: April 15, 2021

Abstract A personalized account is presented describing some of the stories behind scenes in efforts to convert organic chemistry into a more sustainable discipline. These are part group ‘crusade’ started almost 15 years ago aimed at providing technologies illustrative how key reactions used today can be ‘faster, better, cheaper’ when run recyclable water. Hence, option now exists do synthesis far environmentally responsible fashion. By contrast, most developed over past 200 that relies on solvents continues generate enormous amounts pollution, while depleting finite petroleum reserves and our supplies many precious base metals. Making switch water, Nature’s chosen reaction medium, akin which bio-catalysis typically performed, inevitable. 1 The Story Begins: Different Type Prejudice 2 Are We up Challenge? Too Late Now… 3 ‘Impossible’ Reactive Metal Chemistry Water 4 Didn’t I Once Say: ‘It’s All about Ligand’? 5 What Happens When Our Supply Palladium Runs Out? 6 Implications from Tales for Today Tomorrow? 7 Is ‘Broader Impact’ This Work? 8 Bottom Line…

Language: Английский

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Recent advances in the synthesis of active pharmaceutical and agrochemical ingredients in micellar media

Current Opinion in Green and Sustainable Chemistry, Journal Year: 2022, Volume and Issue: 39, P. 100729 - 100729

Published: Nov. 26, 2022

Language: Английский

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Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(7), P. 2853 - 2858

Published: Jan. 1, 2022

Palladium-catalyzed dehydration of primary amides to the corresponding nitriles can be performed in aqueous micelles, without need significant volumes organic co-solvent.

Language: Английский

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Reducing the cost of making drugs for low/limited-income countries by going green

Trends in Chemistry, Journal Year: 2024, Volume and Issue: 6(4), P. 173 - 185

Published: March 28, 2024

In efforts to improve the affordability of drugs in regions world where they are most needed, synthetic sequences described that apply green and sustainable technologies partial or total syntheses several target molecules. Here, focus is on routes to: (i) three antimalarial drugs, key portions thereof; (ii) a targeted polypeptide (as found Paxlovid) used extensively treatment COVID-19; (iii) two subsections potent, timely, anti-HIV agent. Each highlighted by its adherence Principles Green Chemistry, leading more environmentally responsible, hence potentially cost-effective, route associated with their manufacture. Such approaches may impact health well-being millions, while dramatically reducing overall environmental impact.

Language: Английский

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On-Demand Access to Palladium Oxidative Addition Complexes (OACs) from a Stable Organopalladate Salt

Organometallics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Palladium oxidative addition complexes (OACs) are state-of-the-art catalysts for many C–C and C-heteroatom cross-coupling reactions, but altering the ancillary ligand identity (i.e., phosphine, N-heterocyclic carbene) often requires a bespoke synthesis. This has limited modularity accessibility of these ideal catalysts. We report simple admixture approach combining bench-stable organopalladate salt with mono- or bidentate to generate OACs within minutes at room temperature. High yields across suite canonical reactions demonstrate "on-demand" Pd OAC strategy can function as drop-in replacement isolated well several other contemporary precatalysts. Characterization previously unknown coordinated by single NHC also highlights how this circumvent decomposition thermally sensitive that difficult access directly from oxidation reactions.

Language: Английский

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