Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 976 - 976

Published: March 17, 2023

Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation study medicine thanks to advancement field material science and nanomedicine. Improved drug delivery systems with proven efficacy fewer side effects made possible. Nanoformulations varied functions are being created using lipids, polymers, inorganic peptide-based nanomedicines. Therefore, thorough knowledge these intelligent nanomedicines is crucial for developing very promising systems. Polymeric micelles often simple make high solubilization characteristics; result, they seem be alternative other nanosystems. Even though recent studies provided an overview polymeric micelles, here we included discussion on “intelligent” from We also summarized state-of-the-art most micellar respect treatments. Additionally, gave significant attention clinical translation potential treatment various cancers.

Language: Английский

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A Co-Reactive Immunosensor Based on Ti₃C₂T_x MXene@TiO₂–MoS₂ Hybrids Promoting luminol@Au@Ni–Co NCs Electrochemiluminescence for CYFRA 21–1 Detection

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(4), P. 1992 - 1999

Published: March 27, 2024

The construction of assays is capable accurately detecting cytokeratin-19 (CYFRA 21–1), which critical for the rapid diagnosis nonsmall cell lung cancer. In this work, a novel electrochemiluminescence (ECL) immunosensor based on co-reaction promotion luminol@Au@Ni–Co nanocages (NCs) as ECL probe by Ti3C2Tx MXene@TiO2–MoS2 hybrids accelerator was proposed to detect CYFRA 21–1. Ni–Co NCs, derivative Prussian blue analogs, can be loaded with large quantities Au NPs, luminol, and 21–1 secondary antibodies due their high specific surface area. To further improve sensitivity developed immunosensor, were prepared in situ growth TiO2 nanosheets highly conductive MXene, MoS2 homogeneously grown MXene@TiO2 surfaces hydrothermal method. possess excellent catalytic performance electro-redox H2O2 generating more O2·– obtaining optimal intensity luminol/H2O2 system. Under appropriate experimental conditions, quantitative detection range from 0.1 pg mL–1 100 ng mL–1, limit (LOD) 0.046 mL–1. present sensor has lower LOD wider linear range, provides new analytical assay early small-cell-type cancer labels.

Language: Английский

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Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors

Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 622 - 622

Published: June 5, 2023

Electrochemistry is a genuinely interdisciplinary science that may be used in various physical, chemical, and biological domains. Moreover, using biosensors to quantify or biochemical processes critical medical, biological, biotechnological applications. Nowadays, there are several electrochemical for healthcare applications, such as the determination of glucose, lactate, catecholamines, nucleic acid, uric so on. Enzyme-based analytical techniques rely on detecting co-substrate or, more precisely, products catalyzed reaction. The glucose oxidase enzyme generally enzyme-based measure tears, blood, etc. among all nanomaterials, carbon-based nanomaterials have been utilized thanks unique properties carbon. sensitivity can up pM levels nanobiosensor, these sensors very selective, enzymes specific their substrates. Furthermore, frequently fast reaction times, allowing real-time monitoring analyses. These biosensors, however, drawbacks. Changes temperature, pH, other environmental factors influence stability activity enzymes, affecting reliability repeatability readings. Additionally, cost immobilization onto appropriate transducer surfaces might prohibitively expensive, impeding large-scale commercialization widespread use biosensors. This review discusses design, detection, nanobiosensors, recent applications studies evaluated tabulated.

Language: Английский

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Electrochemiluminescence enzyme biosensors for ultrasensitive determination of glucose using glucose dehydrogenase immobilized on vertical silica nanochannels

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 402, P. 135119 - 135119

Published: Dec. 9, 2023

Language: Английский

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Smartphone-based 3D-printed electrochemiluminescence enzyme biosensor for reagentless glucose quantification in real matrices

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 227, P. 115146 - 115146

Published: Feb. 10, 2023

Three-dimensional (3D) printed electrochemical devices are increasingly used in point-of-need and point-of-care testing. They show several advantages such as simple fabrication, low cost, fast response, excellent selectivity sensitivity small sample volumes. However, there only a few examples of analytical combining 3D-printed electrodes with electrochemiluminescence (ECL) detection, an detection principle widely employed clinical chemistry analysis. Herein, portable, miniaturized ECL biosensor for glucose has been developed, based on the luminol/H2O2 system employing two-electrode configuration carbon black-doped polylactic acid (PLA) electrodes. The emission is obtained by means 1.5V AA alkaline battery detected using smartphone camera, thus providing easy portability platform. was successfully applied sensing H2O2 and, upon coupling enzyme oxidase, detection. incorporation luminol oxidase agarose hydrogel matrix allowed to produce preloaded reagents required assay, so that analysis addition. showed ability detect up 5 mmol L−1, limit 60 μmol L−1. also analyse real samples (i.e., saline solutions artificial serum samples) satisfactory results, suggesting its suitability Coupling other oxidases could further extend applicability this

Language: Английский

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Emerging Applications of Nanobiosensors in Pathogen Detection in Water and Food

Biosensors, Journal Year: 2023, Volume and Issue: 13(10), P. 922 - 922

Published: Oct. 11, 2023

Food and waterborne illnesses are still a major concern in health food safety areas. Every year, almost 0.42 million 2.2 deaths related to illness reported worldwide, respectively. In foodborne pathogens, bacteria such as Salmonella, Shiga-toxin producer Escherichia coli, Campylobacter, Listeria monocytogenes considered be high-concern pathogens. High-concern pathogens Vibrio cholerae, leptospirosis, Schistosoma mansoni, Schistosima japonicum, among others. Despite the efforts of water quality control monitor presence these kinds sources, occurrence is high globally. For reasons, development novel faster pathogen-detection methods applicable real-time surveillance strategies required. Methods based on biosensor devices have emerged tools for detection contrast traditional that usually time-consuming unsuitable large-scale monitoring. Biosensor can summarized use biochemical reactions with biorecognition section (isolated enzymes, antibodies, tissues, genetic materials, or aptamers) detect most cases, biosensors correlation electrical, thermal, optical signals pathogen biomarkers. The application nano molecular technologies allows identification high-sensibility manner, at extremely low-pathogen concentrations. fact, integration gold, silver, iron, magnetic nanoparticles (NP) has demonstrated an improvement their functionality. present review summarizes principal nanomaterials biosensor-based samples. Additionally, it highlights through nanomaterials. Nanomaterials offer unique advantages detection. nanoscale specific surface area more effective interaction pathogenic agents, enhancing sensitivity selectivity biosensors. Finally, biosensors’ capability functionalize molecules antibodies nucleic acids facilitates target

Language: Английский

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From theory to practice: understanding the challenges in the implementation of electrogenerated chemiluminescence for analytical applications

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(6)

Published: May 31, 2024

Electrogenerated chemiluminescence (ECL) stands out as a remarkable phenomenon of light emission at electrodes initiated by electrogenerated species in solution. Characterized its exceptional sensitivity and minimal background optical signals, ECL finds applications across diverse domains, including biosensing, imaging, various analytical applications. This review aims to serve comprehensive guide the utilization Beginning with brief exposition on theory basis generation, we elucidate systems employed initiate ECL. Furthermore, delineate principal utilized for generation contexts, elucidating both advantages challenges inherent their use. Additionally, provide an overview different electrode materials novel ECL-based protocols tailored purposes, specific emphasis biosensing

Language: Английский

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Microfluidic paper-based analytical devices for cancer diagnosis

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 379, P. 133243 - 133243

Published: Dec. 28, 2022

Language: Английский

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Recent progress on nanozymes in electrochemical sensing

Journal of Electroanalytical Chemistry, Journal Year: 2023, Volume and Issue: 936, P. 117391 - 117391

Published: March 27, 2023

Language: Английский

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Self-enhanced Electrochemiluminescence Luminophore Based on Pd Nanocluster-Anchored Metal Organic Frameworks via Ion Annihilation for Sensitive Cell Assay of Human Lung Cancer

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(50), P. 18572 - 18578

Published: Dec. 8, 2023

Electrochemiluminescence (ECL) has attracted significant interest in the analysis of cancer cells, where ruthenium(II)-based emitter demonstrates urgency and feasibility to improve ECL efficiency. In this work, self-enhanced luminophore was prepared by covalent anchoring Pd nanoclusters on aminated metal organic frameworks (Pd NCs@MOFs), followed linkage with bis(2,2′-bipyridine)-5-amino-1,10-phenanthroline ruthenium(II) (RuP). The resultant showed 214-fold self-magnification efficiency over RuP alone, combined promoting interfacial photoelectron transfer. enhanced mechanism through ion annihilation critically proved controlled experiments density functional theory (DFT) calculations. Based above, a "signal off" biosensor built assembly tyrosine kinase 7 (PTK-7) aptamer (Apt) established sensing platform for human lung cells (A549). sensor lower detection limit 8 mL–1, achieving single-cell detection. This work reported strategy synthesis advanced emitters, exploring biosensing devices cancers.

Language: Английский

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