Green synthesis of collagen nanoparticles by Streptomyces xinghaiensis NEAA-1, statistical optimization, characterization, and evaluation of their anticancer potential

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 8, 2024

Abstract Collagen nanoparticles (collagen-NPs) are promising biopolymeric due to their superior biodegradability and biocompatibility. The low immunogenicity non-toxicity of collagen-NPs makes it preferable for a wide range applications. A total eight morphologically distinct actinomycetes strains were newly isolated from various soil samples in Egypt. cell-free supernatants these tested ability. These strains' ability synthesize collagen-NPs. Five isolates had the biosynthesize Among these, potential culture, Streptomyces sp. NEAA-1, was chosen identified as xinghaiensis NEAA-1 based on 16S rRNA sequence analysis well morphological, cultural physiological properties. data has been deposited at GenBank database under accession No. OQ652077.1. Face-centered central composite design (FCCD) conducted maximize biosynthesis. Maximum 8.92 mg/mL condition 10 collagen concentration, initial pH 7, incubation time 48 h temperature 35 °C. yield obtained via FCCD optimization (8.92 mg/mL) 3.32-fold compared non-optimized conditions (2.5 mg/mL). TEM showed hollow sphere nanoscale particles with mean 32.63 ± 14.59 nm diameter. FTIR spectra major peaks amide I, II III also supernatant involved effective capping biosynthesized exhibited anti-hemolytic, antioxidant cytotoxic activities. inhibitory concentrations (IC 50 ) against MCF-7, HeP-G2 HCT116 cell lines 11.62 0.8, 19.60 1.2 41.67 2.2 µg/mL; respectively. in-vivo investigation that can suppress Ehrlich ascites carcinoma (EAC) growth mice. collagen-NPs/DOX combination treatment considerable tumor suppression (95.58%). Collagen-NPs evaluated nanocarrier chemotherapeutic agent, methotrexate (MTX). average size MTX loaded 42.73 3.5 nm. Encapsulation efficiency percentage (EE %) 48.91% drug loading (DL 24.45%.

Language: Английский

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Visible Light‐ and Heat‐Promoted C−O Coupling Reaction of Phenols and Aryl Halides

Asian Journal of Organic Chemistry, Journal Year: 2019, Volume and Issue: 9(1), P. 116 - 120

Published: Dec. 21, 2019

Abstract A visible light‐ and heat‐promoted C‐O coupling reaction of phenols aryl halides has been described. Compared to the traditional reactions promoted by light, this strategy avoids use transition metals, photocatalysts ligands. Moreover, good substrate universality, suitable for substituted phenol, naphthol heterocyclic phenol derivatives.

Language: Английский

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Iridium/Acid Cocatalyzed Direct Access to Fused Indoles via Transfer Hydrogenative Annulation of Quinolines and 1,2-Diketones

Organic Letters, Journal Year: 2020, Volume and Issue: 22(6), P. 2308 - 2312

Published: Feb. 28, 2020

Herein, we present an unprecedented iridium/acid cocatalyzed construction of fused indoles via transfer hydrogenative annulation nonactivated quinolines and 1,2-diketones. The products are assembled initial reduction followed by selective coupling 1,2-diketones with the N C8 sites quinolyl skeleton. developed synthetic method features operational simplicity, readily available feedstocks, applicability for streamline synthesis functional molecules, high step atom efficiency, generation water as byproduct.

Language: Английский

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Selective reductive annulation reaction for direct synthesis of functionalized quinolines by a cobalt nanocatalyst

Journal of Catalysis, Journal Year: 2020, Volume and Issue: 383, P. 239 - 243

Published: Feb. 13, 2020

Language: Английский

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Mg–Al hydrotalcite-based catalysts for one-pot synthesis of quinoline derivatives

Tetrahedron Green Chem, Journal Year: 2023, Volume and Issue: 1, P. 100004 - 100004

Published: Jan. 1, 2023

This mini-review discusses Mg–Al hydrotalcite-based catalyst systems used for modified Friedländer quinoline synthesis. The metal-grafted hydrotalcites consist of both active metal species and base sites capable advancing catalytic activity. Ru-grafted catalysts are the oxidative dehydrogenation 2-aminobenzyl alcohol to 2-aminobenzaldehyde, followed by base-catalyzed condensation with ketones 2-substituted quinolines. Fe-grafted also act as heterogeneous one-pot synthesis at a slightly higher reaction temperature. For pure hydrotalcite, hydrogen transfer reactions occur afford 2-aminobenzaldehyde intermediate an alcohol, resulting in consequent production corresponding mechanism substrate scope each system discussed.

Language: Английский

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Porous FeO(OH) Dispersed on Mg‐Al Hydrotalcite Surface for One‐Pot Synthesis of Quinoline Derivatives

ChemCatChem, Journal Year: 2021, Volume and Issue: 13(12), P. 2915 - 2921

Published: March 29, 2021

Abstract The use of ubiquities elements such as iron instead expensive precious metals catalysts is one goal toward realizing environmentally benign synthetic chemistry. Here, we report that porous FeO(OH) dispersed on Mg−Al hydrotalcite acts a bifunctional heterogeneous catalyst in the one‐pot synthesis 2‐substituted quinoline derivatives through dehydrogenative oxidation‐cyclization reactions. was prepared by simple grafting method using FeCl 3 and hydrotalcite. possesses higher surface area than those previously reported for α‐FeO(OH) particles. proceeded effectively under non‐noble‐metal catalysis air without requiring additional homogeneous bases or solvents.

Language: Английский

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Click reactions catalyzed by Cu(I) complexes supported with dihydrobis(2-mercapto-benzimidazolyl)borate and phosphine ligands

Inorganica Chimica Acta, Journal Year: 2020, Volume and Issue: 506, P. 119470 - 119470

Published: Jan. 31, 2020

Language: Английский

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Practical Synthesis of Isoindolines Yields Potent Colistin Potentiators in Multidrug-Resistant Acinetobacter baumannii

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(20), P. 4057 - 4061

Published: Jan. 1, 2024

An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing an isoindole umpolung strategy. A variety were prepared with good to excellent yields. Biological screens these identified compounds demonstrated that they are potent potentiators colistin for multi-drug resistant

Language: Английский

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Investigation of Structures, FTIR, FT-Raman, In Vivo Anti-Inflammatory, Molecular Docking and Molecular Characteristics of 2-Amino-3-Pyridine Carboxaldehyde and Its Copper(II) Complex Using Experimental and Theoretical Approach

Polycyclic aromatic compounds, Journal Year: 2020, Volume and Issue: 42(1), P. 226 - 248

Published: Feb. 11, 2020

In this work, the FT-Raman and FTIR spectra of synthesized molecules, 2-amino-3-pyridine carboxaldehyde (APC) Cu(II) complex (Cu(II)APC) were characterized by using density functional theory (DFT). The optimized structural parameters such as harmonic vibrational frequencies, general valence force field, infrared Raman intensities, frontier molecular orbital parameters, NLO properties, NBO MESP calculated B3LYP with 6-311++G(d,p) basis set. Employing MOLVIB 7.0 program, scaling process was engaged to reach a good agreement between experimental computed frequencies. rms error scaled frequencies found at 9.1 10.3 cm–1 J. Liang, Y. Wang, Yu, Li, R. Xu, "Synthesis Structure New Layered Zinc Phosphite (C5H6N2)Zn(HPO3) Containing Helical Chains," Chemical Communications 7, no. 7 (2003): 882–3.[Crossref], [Web Science ®] , [Google Scholar]. Unambiguous assignments reported potential energy distribution (PED) eigenvectors. APC Cu(II)APC evaluated for their anti-inflammatory activity carrageenan-induced paw oedema method. exhibited significant compared standard drug. Molecular docking results support title compounds against target protein cyclooxygenase-2 (COX-2) possess binding values –4.50 –7.67 kcal/mol, respectively.

Language: Английский

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Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Jan. 22, 2021

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious scalable approach to synthesize biologically interesting isoxazoline derivatives with good excellent yields.

Language: Английский

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