Royal Society Open Science,
Journal Year:
2024,
Volume and Issue:
11(6)
Published: June 1, 2024
Macrocyclic
polyamines
constitute
a
significant
class
of
macrocyclic
compounds
that
play
pivotal
role
in
the
realm
supramolecular
chemistry.
They
find
extensive
applications
across
diverse
domains
including
industrial
and
agricultural
production,
clinical
diagnostics,
environmental
protection
other
multidisciplinary
fields.
possess
distinctive
cavity
structure
with
varying
sizes,
depths,
electron-richness
degrees
flexibilities.
This
unique
feature
enables
them
to
form
specific
structures
through
complexation
objects,
thereby
attracting
considerable
attention
from
chemists,
biologists
materials
scientists
alike.
However,
there
is
currently
lack
comprehensive
summaries
on
synthesis
methods
for
polyamines.
In
this
review
article,
we
provide
an
in-depth
introduction
while
analysing
their
respective
advantages
disadvantages.
Furthermore,
also
present
overview
recent
5-year
advancements
using
as
non-viral
gene
vectors,
fluorescent
probes,
diagnostic
therapeutic
reagents
well
catalysts.
Looking
ahead
future
research
directions
application
various
fields
will
hopefully
inspire
new
ideas
use.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(11), P. 7106 - 7164
Published: May 17, 2024
The
identification
and
detection
of
disease-related
biomarkers
is
essential
for
early
clinical
diagnosis,
evaluating
disease
progression,
the
development
therapeutics.
Possessing
advantages
high
sensitivity
selectivity,
fluorescent
probes
have
become
effective
tools
monitoring
active
molecules
at
cellular
level
in
vivo.
In
this
review,
we
describe
current
designed
quantification
key
bioactive
associated
with
common
diseases,
such
as
organ
damage,
inflammation,
cancers,
cardiovascular
brain
disorders.
We
emphasize
strategies
behind
design
capable
biomarker
diagnosis
cover
some
aspects
combined
diagnostic/therapeutic
based
on
regulating
molecules.
This
review
concludes
a
discussion
challenges
outlook
probes,
highlighting
future
avenues
research
that
should
enable
these
to
achieve
accurate
biomedical
applications.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
53(3), P. 1354 - 1374
Published: Dec. 20, 2023
A
database
of
over
2000
different
ligands
that
bind
amyloid
fibrils
(Aβ,
tau,
or
αSyn)
has
been
compiled
and
used
to
investigate
the
factors
influence
binding
affinity
selectivity.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(12), P. 13556 - 13591
Published: March 11, 2024
Alzheimer's
disease
(AD)
is
the
most
common
form
of
neurodegenerative
dementia
that
rapidly
becoming
a
major
health
problem,
especially
in
developed
countries
because
their
increasing
life
expectancy.
Two
main
problems
are
often
associated
with
disease:
(i)
absence
widely
accessible
"gold-standard"
for
early
diagnosis
and
(ii)
lack
effective
therapies
disease-modifying
effects.
The
recent
success
monoclonal
antibody
lecanemab
played
an
important
role
not
only
clarifying
possible
druggable
pathway
but
also
spelling
revival
small
molecule
drug
discovery.
Unlike
bulky
biologics,
molecules
structurally
less
complex,
generally
cheaper,
compatible
at-home
oral
consumption,
making
it
feasible
people
to
start
regimen
stay
on
longer.
In
this
sense,
small-molecule
near-infrared
fluorescent
theranostics
have
been
gaining
more
attention
from
scientific
community,
as
they
potential
simultaneously
provide
diagnostic
outputs
deliver
therapeutic
action,
paving
way
toward
personalized
medicine
AD
patients.
They
shift
"status-quo"
expensive
limited-access
PET
radiotracers
inexpensive
handy
imaging
tools
available
primary
patient
screening
preclinical
animal
studies.
Herein,
we
review
advances
field
disease,
detailing
design
strategies,
synthetic
approaches
properties
vitro
vivo.
With
Review,
intend
milestone
acquired
knowledge
theranostics,
encouraging
future
development
properly
designed
theranostic
compounds
improved
chances
reach
clinical
applications.
Analytical Methods,
Journal Year:
2023,
Volume and Issue:
16(2), P. 293 - 300
Published: Nov. 19, 2023
Viscosity,
an
essential
parameter
of
the
cellular
microenvironment,
has
ability
to
indicate
condition
living
cells.
It
is
closely
linked
numerous
diseases
like
Alzheimer's
disease,
diabetes,
and
cardiovascular
disorders.
Therefore,
it
necessary
design
tools
effectively
monitor
viscosity
changes,
which
could
provide
promising
avenues
for
therapeutic
interventions
in
these
diseases.
Herein,
we
report
a
novel
mitochondria-targeting
fluorescent
probe
GX-VS
was
suitable
detection
changes
