Journal of Clinical Research and Clinical Trials,
Journal Year:
2023,
Volume and Issue:
2(3), P. 1 - 4
Published: Nov. 7, 2023
Compromised
immune
function
and
environment
in
cancer
patients
create
a
situation
where
the
system
is
unable
to
effectively
detect
eliminate
cells.
This
allows
tumors
grow
evade
surveillance,
leading
disease
progression.
Understanding
these
immune-related
challenges
crucial
for
developing
effective
treatments,
such
as
immunotherapies,
that
aim
boost
response
against
cancer.
Except
conventional
dietary
interventions
have
been
found
help
by
potentially
improving
their
nutritional
support,
boost,
gut
microbiome
influence,
etc.
Also,
it’s
indispensable
notice
should
be
personalized,
taking
into
account
specific
needs,
preferences,
tolerances
of
each
patient.
review
aims
emphasize
importance
applying
well
modified
proper
anti-cancer
immunity
patients.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: July 18, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
highly
aggressive
cancer
characterized
by
late
diagnosis,
rapid
progression,
and
high
mortality
rate.
Its
complex
biology,
dense,
stromal
tumor
environment
with
an
immunosuppressive
milieu,
contributes
to
resistance
against
standard
treatments
like
chemotherapy
radiation.
This
comprehensive
review
explores
the
dynamic
role
of
microbiome
in
modulating
efficacy
outcomes
PDAC.
It
delves
into
microbiome's
impact
on
drug
metabolism
resistance,
interaction
between
microbial
elements,
drugs,
human
biology.
We
also
highlight
significance
specific
bacterial
species
enzymes
influencing
action
immune
response
microenvironment.
Cutting-edge
methodologies,
including
artificial
intelligence,
low-biomass
analysis
patient-derived
organoid
models,
are
discussed,
offering
insights
nuanced
interactions
microbes
cells.
The
potential
microbiome-based
interventions
as
adjuncts
conventional
PDAC
paving
way
for
personalized
therapy
approaches.
synthesizes
recent
research
provide
in-depth
understanding
how
affects
efficacy.
focuses
elucidating
key
mechanisms
identifying
existing
knowledge
gaps.
Addressing
these
gaps
crucial
enhancing
medicine
refining
treatment
strategies,
ultimately
improving
patient
outcomes.
Cancer Reports,
Journal Year:
2023,
Volume and Issue:
6(11)
Published: July 17, 2023
Abstract
Background
Prebiotics
is
a
relatively
neglected
area
in
cancer
research,
despite
evidence
suggesting
that
it
plays
key
role
suppressing
tumour
growth
and
improving
immune
function.
Recent
Findings
Including
prebiotics
the
diet
has
been
shown
to
strengthen
system
can
better
slow
down
or
prevent
of
tumours.
It
also
strongly
indicated
various
scientific
studies
contribute
sustenance
healthy
microbiome,
which
turn
an
important
increasing
effectiveness
reducing
side
effects
treatments.
Conclusion
In
present
review
article
we
highlight
mechanisms
by
like
inulin,
fructooligosaccharide
(FOS),
β‐glucan,
pectin,
xylooligosaccharide
(XOS)
Furthermore,
beneficial
effect
incorporating
during
therapy
improvise
gut
health
prevent/reverse
damage
caused
patients
due
chemotherapy
elaborated.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 19, 2024
Abstract
Mild
and
persisting
gastrointestinal
symptoms
(MPGS)
as
bloating,
constipation
or
diarrhea
are
widespread
in
older
adults
often
accompanied
by
gut
microbiota
dysbiosis.
Nutritional
interventions
help
to
regulate
restore
function.
In
this
non-randomized
continuous
prospective
cohort
study,
we
evaluated
the
effects
of
a
21-day
intervention
using
dietary
dairy-based
supplement
(AGIJOY™)
on
self-reported
(GI)
symptoms,
fecal
composition
short
chain
fatty
acids
(SCFA)
levels
Chinese
(N
=
46,
age
27–73)
suffering
from
MPGS.
Questionnaire
data
samples
were
collected
at
baseline
(D0),
day
7
21
(D7
D21).
The
results
showed
significant
improvement
GI
D21
gradual
shift
composition.
first
week
intervention,
relative
abundance
(RA)
bifidobacteria
significantly
increased
RA
Bacteroides
Helicobacter
decreased
(
p
<
0.05).
SCFA
remained
unchanged
during
study.
To
our
knowledge,
is
study
testing
effect
prebiotic
postbiotic
containing
milk-based
blend
MPGS
among
population
under
real
living
environment.
Cancer Reports,
Journal Year:
2023,
Volume and Issue:
6(11)
Published: Nov. 1, 2023
Cancer,
a
multifactorial
culmination,
is
one
of
the
leading
causes
death
in
men
and
women
globally.
Exposure
to
or
more
cancer-causing
agents,
such
as
smoking,
alcohol,
alkylating
radiations,
secondary
risk
factors,
obesity
certain
infections,
work
together
promote
cancer
development.
Our
current
mechanistic
understanding
development
suggests
that
environmental
including
atypical
microbiota,
influence
susceptibility,
particularly
individuals
who
are
genetically
predisposed
Approximately
15%–20%
human
cancers
causally
linked
with
microbial
pathogens.
Recent
findings
from
taxonomic
metabolomics
analyses
gut
microbiota
communities
residing
within
tumors
have
enhanced
our
microbiome-dependent
regulation
carcinogenesis.
The
potential
modulate
efficacy
toxicity
anticancer
drugs
further
expands
significance
prevention
therapy,
warranting
in-depth
discussion.
“Cancer
Microbiome”
special
issue
encompasses
original
research
review
articles
provide
insights
into
recent
role
cancer,
promises
microbiome-based
therapies
for
treatment.
This
also
emphasizes
products
host
metabolism
circulation
metabolites
may
incidence
progression.
complex
ecosystem
trillions
bacteria,
archaea,
viruses,
fungi
reside
digestive
tract.
These
microbes
been
known
help
metabolize
food
materials
pharmaceutical
drugs.
Moreover,
balanced
functional
community
trains
fine-tunes
immunological
cellular
responses
kill
invading
pathogens
initiate
cancer-fighting
immune
response.
Therefore,
disruption
this
intricate
relationship
has
implicated
variety
neoplasms.
Unsurprisingly,
arising
gastrointestinal
tract
thought
close
association
gut.
Beneficial
modulation
through
intake
dietary
fibers—nondigestible
carbohydrates—has
gained
enormous
attention.
A
group
led
by
Dr.
Bhisham
Narayan
Singh
Ashwini
Kumar
reviewed
benefits
prebiotics—fermentable
fibers
stimulate
growth
beneficial
bacteria
gut—for
overall
health
tract.1
authors
elaborated
on
interactions
between
prebiotics,
how
these
improve
functions
system.
They
described
effects
individual
combined
prebiotics
cancers,
wherein
components
inulin
health.
In
contrast,
Vishal
observed
refined
fiber
inulin,
commonly
present
processed
foods,
abnormal
accumulation
succinate
gut,
which
leads
colon
inflammation
tumorigenesis
mouse
model.2
previously
shown
inclusion
inulin-enriched
high-fat
diet
promotes
hepatocellular
carcinoma
mice.
Here,
discuss
selectively
enrich
particular
bacterial
groups
enhance
colonic
inflammation.
Thus,
studies
highlight
necessity
thoroughly
evaluate
claimed
health-promoting
effects.
Further,
Indranil
Chattopadhyay
landscape
associated
gastric
cancer.3
roles
virulence
factors
secreted
several
Escherichia
coli,
Lactobacillus,
Streptococcus,
so
on,
addition
Helicobacter
pylori,
lead
cancer.
they
explained
possibility
using
future
biomarkers
diagnosis
prognosis
Breast
most
heterogeneous
amongst
frequently
diagnosed
worldwide.
change
lifestyle,
along
genetic
physiological
predisposition,
increased
propensity
breast
mortality
disease.
Interestingly,
despite
being
distant
seemingly
unrelated
breast,
alterations
composition
profound
breasts
women,
progression
article
Sneha
Joshi
Rupa
Mishra
explains
differences
tissue
occurrence
subtypes.4
emphasized
responses.
highlighted
artificial
intelligence
machine
learning
dysbiosis
biomarker.
Mukul
S.
Godbole
importance
microbiome
levels
circulating
estrogen
progesterone
cancer.5
While
previous
progesterone,
provides
thorough
investigation
confer
effect
humans
via
metabolic
activities
microbiome.
Their
describes
interindividual
response
conferred
microbiome,
highlighting
diverse
complete
chemo-,
immune-,
hormonal-therapy.
Efficient
form
basis
counteracting
pathogenic
invasions.
especially
helps
maintain
an
intact
immunity.
However,
chronic
diversity
immensely
impact
responses,
thus
diseased
conditions.
Asmita
Das
phenomenon
emphasis
immune-related
receptors,
toll-like
receptors
NOD-like
receptors.6
An
alteration
correlated
incidence.
propose
it
imperative
ensure
healthy,
prevent
infections.
Tobacco
papillomavirus
(HPV)
infection
were
considered
among
primary
head
neck
region.
investigations
elucidated
strong
oral
cancers.
compositions
minimal,
can
alter
key
carcinogenic
substances
cause
infections
regions
formation
articulated
Sanket
Desai
genomic
epigenomic
induced
comprising
fungi,
various
HPV,
Epstein–Barr
virus,
hepatitis
B
C
viruses.7
changes
include
somatic
copy
number
changes,
expression
deletions,
global
hypomethylation.
Previously,
Fusobacterium
HPV-negative
largely
grouped
HPV-positive
groups,
efforts
like
should
enable
rectify
binary
groupism
elaborate
distribution
All
published
limitations
Articles
express
need
develop
strategies
counterbalance
dysbiotic
conditions
cells,
causal
remains
be
established
majority
microorganisms,
warrant
focused
elucidating
We
sincerely
hope
will
advance
microbiome's
involvement
therapeutics,
well
increase
awareness
clinicians,
researchers,
general
public.
interaction
treatment
clinical
outcomes
future.
Godbole:
Writing–original
draft,
writing–review
editing;
Singh:
editing.
acknowledges
support
emoluments
Vishwanath
Karad
MIT
World
Peace
University.
Both
read
approved
final
version
manuscript.
stated
explicitly
there
no
conflicts
interest
connection
article.
Not
applicable.
Data
sharing
not
applicable
datasets
generated
analyzed
during
study.
Advances in chemical and materials engineering book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 275 - 316
Published: June 30, 2024
Nanotechnology
has
emerged
as
a
revolutionary
field
with
the
potential
to
transform
various
aspects
of
science
and
technology.
Nanomaterials,
defined
materials
at
least
one
dimension
in
nanometer
range
(typically
1-100
nanometers),
exhibit
properties
distinct
from
their
bulk
counterparts.
Their
large
surface
area
unique
arising
nanoscale
dimensions,
quantum
effects,
tunable
behavior
make
them
invaluable
tools
biomedicine.
These
offer
exciting
opportunities
for
diagnostics,
drug
delivery,
tissue
engineering,
more.
In
this
chapter,
we
delve
into
comprehensive
analysis
synthesis
techniques
highlights
innovative
applications
nanomaterials
biomedicine,
emphasizing
impact
on
advancing
research
healthcare.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(42), P. 56580 - 56598
Published: Oct. 14, 2024
mRNA-based
nonviral
gene
therapy
has
played
an
important
role
in
cancer
therapy,
however,
the
limited
delivery
efficiency
and
therapeutic
capacity
still
require
further
exploration
enhancement.
Immunogene
provides
a
strategy
for
treatment.
Bacteria
are
tiny
single-celled
living
organisms,
many
of
which
can
be
found
on
human
body
beneficial
to
humans.
Lactobacillus
reuteri
is
bacterial
member
gut
flora,
recent
research
shown
that
it
reduce
intestinal
inflammation
by
stimulating
immunomodulatory
response.
L.
lysate
represents
ideal
resource
constructing
advanced
mRNA
systems
with
immune
stimulation
potential.
Here,
we
prepared
bifunctional
system
DMP-Lac
(DOTAP-mPEG–PCL-L.
lysate),
successfully
codelivered
IL-23A
mRNA,
exhibited
high
75.56%
±
0.85%,
strongly
promoted
maturation
activation
vivo.
Both
CT26
abdominal
metastasis
model
lung
also
good
effect,
tumor
inhibition
rate
DMP-Lac/IL-23A
group
reached
97.92%.
Protein
chip
technology
verified
DMP
acted
as
adjuvant,
demonstrating
could
regulate
related
cells,
while
IL-23
caused
changes
downstream
factors,
thus
producing
corresponding
treatment
effect.
The
complex
strong
anticancer
immunotherapeutic
effects.
Our
results
demonstrated
this
formulation
served
tumor-specific
nanomedicine,
providing
colon
immunogene
therapy.
