All-photonic kinase inhibitors: light-controlled release-and-report inhibition DOI Creative Commons
Cassandra L. Fleming, Carlos Benitez‐Martin, Elin Bernson

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(18), P. 6897 - 6905

Published: Jan. 1, 2024

An all-photonic method is described, in which (i) the release of an active kinase inhibitor controlled externally with light; and (ii) fluorescence employed to report both binding its corresponding target.

Language: Английский

Molecular photoswitches in aqueous environments DOI Creative Commons
Jana Volarić, Wiktor Szymański, Nadja A. Simeth

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(22), P. 12377 - 12449

Published: Jan. 1, 2021

Molecular photoswitches are inherently lipophilic and do not spontaneously dissolve in water. We describe the effect of water on photochemical properties strategies to solubilize organic apply them aqueous media.

Language: Английский

Citations

276
The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy DOI Creative Commons
Hai‐Hao Han, Han-Min Wang, Paramesh Jangili

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 879 - 920

Published: Jan. 1, 2023

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables development improved therapies.

Language: Английский

Citations

153
Wavelength-selective light-matter interactions in polymer science DOI Creative Commons
Pengtao Lu, Dowon Ahn, Ruhamah Yunis

et al.

Matter, Journal Year: 2021, Volume and Issue: 4(7), P. 2172 - 2229

Published: July 1, 2021

Language: Английский

Citations

72
In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M DOI Creative Commons
Li Gao, Joyce C. M. Meiring,

Adam Varady

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(12), P. 5614 - 5628

Published: March 15, 2022

Photoswitchable reagents are powerful tools for high-precision studies in cell biology. When these globally administered yet locally photoactivated two-dimensional (2D) cultures, they can exert micron- and millisecond-scale biological control. This gives them great potential use biologically more relevant three-dimensional (3D) models

Language: Английский

Citations

40
Photo-controllable biochemistry: Exploiting the photocages in phototherapeutic window DOI Creative Commons
Hao Xiong, Yunjie Xu,

Byungkook Kim

et al.

Chem, Journal Year: 2022, Volume and Issue: 9(1), P. 29 - 64

Published: Dec. 1, 2022

Language: Английский

Citations

39
Advanced near‐infrared light approaches for neuroimaging and neuromodulation DOI Creative Commons

Hongqiang Yin,

Wuqiao Jiang,

Yongyang Liu

et al.

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: May 5, 2023

Abstract Almost all physiological processes of animals are controlled by the brain, including language, cognitive, memory, learning, emotion and so forth. Minor brain dysfunction usually leads to diseases disorders. Therefore, it' is greatly meaningful urgent for scientists have a better understanding structure function. Optical approaches can provide powerful tools imaging modulating brain. In particular, optical in near‐infrared (NIR) window (700–1700 nm) exhibit excellent prosperities deep tissue penetration low scattering absorption compared with those visible windows (400–700 nm), which provides promising approach develop desired methods neuroimaging neuromodulation tissues. this review, variable types NIR light neural ions, membrane potential, neurotransmitters, other critical molecules functions summarized. latest breakthrough research regulation NIR‐II (1000–1700 highlighted. Finally, we conclude challenges prospects light‐based both basic further clinical translation.

Language: Английский

Citations

33
Turning Red without Feeling Embarrassed─Xanthenium-Based Photocages for Red-Light-Activated Phototherapeutics DOI Creative Commons

Alexandra Egyed,

Krisztina Németh,

Tibor Á. Molnár

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4026 - 4034

Published: Feb. 8, 2023

Herein, we present high-yielding, concise access to a set of xanthenium-derived, water-soluble, low-molecular-weight photocages allowing light-controlled cargo release in the green red region. Very importantly, these new allow installation various payloads through ester, carbamate, or carbonate linkages even at last stage synthesis. Payloads were uncaged with high efficiency upon green, orange, light irradiation, leading carboxylic acids, phenols, and amines. The near-ideal properties carboxanthenium derivative further evaluated context drug using camptothecin-derived chemotherapeutic drug, SN38. Notably, caged showed orders magnitude lower cellulo, which was reinstated after irradiation. presented offer that facilitate translation photoactivated chemotherapy toward clinical applications.

Language: Английский

Citations

29
Photochemistry in Medicinal Chemistry and Chemical Biology DOI
Wenyong Zhu, Claire Empel, Sveva Pelliccia

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(6), P. 4322 - 4345

Published: March 8, 2024

Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced reactions enable efficient synthesis of intricate structures and have found applications throughout different stages drug discovery development processes. Moreover, photochemical techniques provide innovative solutions biology, allowing precise spatiotemporal activation targeted delivery. In this Perspective, we highlight already numerous remarkable even more promising future photochemistry chemistry biology.

Language: Английский

Citations

12
BODIPY-based photocages: rational design and their biomedical application DOI
Heng Li, Jun Wang, Lijuan Jiao

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(45), P. 5770 - 5789

Published: Jan. 1, 2024

This highlight reviews various strategies for constructing BODIPY-based photocages, their photodecaging mechanisms, and applications in the biomedical field.

Language: Английский

Citations

8
Advances in BODIPY photocleavable protecting groups DOI
Praveen Kumar Singh, Poulomi Majumdar, Surya Prakash Singh

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 449, P. 214193 - 214193

Published: Sept. 20, 2021

Language: Английский

Citations

48