Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: June 12, 2024
Abstract
Photoresponsive
drug
delivery
systems
(PDDSs)
have
emerged
as
a
promising
toolbox
for
delivery,
offering
precise
control
over
the
site,
duration,
and
dosage
of
light‐triggered
medication.
It
allows
controlled
release,
photo‐triggered
targeting,
diagnosis,
treatment,
improving
precision
efficacy
therapies
various
diseases.
Despite
progress
in
designing
different
PDDSs,
clinical
translation
has
been
limited
due
to
obstacles.
Herein,
this
review
article
focuses
on
three
critical
challenges
PDDSs:
1)
accumulation
at
diseased
lesions,
2)
light
irradiation,
3)
penetration
tissues.
Also,
summarizes
discusses
current
advancements
strategies
address
these
challenges.
Overall,
it
emphasizes
need
clarify
from
bench
bedside
develop
enhance
therapeutic
outcomes,
increase
compatibility
patient
compliance,
unlock
possibilities
therapies.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(16), P. 5607 - 5651
Published: Jan. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2699 - 2804
Published: Feb. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
63, P. 102754 - 102754
Published: May 18, 2023
Oxidative
stress
(OS),
defined
as
redox
imbalance
in
favor
of
oxidant
burden,
is
one
the
most
significant
biological
events
cancer
progression.
Cancer
cells
generally
represent
a
higher
level,
which
suggests
dual
therapeutic
strategy
by
regulating
status
(i.e.,
pro-oxidant
therapy
and/or
antioxidant
therapy).
Indeed,
exhibits
great
anti-cancer
capability,
attributing
to
accumulation
within
cells,
whereas
restore
homeostasis
has
been
claimed
fail
several
clinical
practices.
Targeting
vulnerability
pro-oxidants
capable
generating
excessive
reactive
oxygen
species
(ROS)
surfaced
an
important
strategy.
However,
multiple
adverse
effects
caused
indiscriminate
attacks
uncontrolled
drug-induced
OS
on
normal
tissues
and
drug-tolerant
capacity
some
certain
greatly
limit
their
further
applications.
Herein,
we
review
representative
oxidative
drugs
summarize
side
organs,
emphasizing
that
seeking
balance
between
damage
value
exploiting
next-generation
OS-based
chemotherapeutics.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: Sept. 25, 2023
Unsatisfied
tumor
accumulation
of
chemotherapeutic
drugs
and
a
complicated
immunosuppressive
microenvironment
diminish
the
immune
response
rate
therapeutic
effect.
Surface
modification
these
with
target
ligands
can
promote
their
cellular
internalization,
but
modified
may
be
subjected
to
unexpected
recognition
clearance.
Herein,
phenylboronic
acid
(PBA)
group-shieldable
dendritic
nanomedicine
that
integrates
an
immunogenic
cell
death
(ICD)-inducing
agent
(epirubicin,
Epi)
indoleamine
2,3-dioxgenase
1
(IDO1)
inhibitor
(NLG919)
is
reported
for
chemo-immunotherapy.
This
NLG919-loaded
Epi-conjugated
PEGylated
dendrimers
bridged
boronate
bonds
(NLG919@Epi-DBP)
maintains
stable
nanostructure
during
circulation.
Under
moderate
acidic
condition,
PBA
group
exposes
sialic
residue
on
membrane
enhance
internalization
penetration
NLG919@Epi-DBP.
At
pH
5.0,
NLG919@Epi-DBP
rapidly
disassembles
release
incorporated
Epi
NLG919.
triggers
robust
ICD
cells
evokes
strong
response.
In
addition,
inhibition
IDO1
activity
downregulates
metabolism
L-tryptophan
kynurenine,
leading
reduction
in
recruitment
modulation
microenvironment.
Collectively,
this
promising
strategy
has
been
demonstrated
evoke
as
well
remodel
enhanced
chemo-immunotherapeutic
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(13), P. 5747 - 5753
Published: March 23, 2023
Drug-induced
liver
injury
(DILI)
is
a
major
clinical
issue
associated
with
the
majority
of
commercial
drugs.
During
DILI,
peroxynitrite
(ONOO-)
level
upregulated
in
liver.
However,
traditional
methods
are
unable
to
timely
monitor
dynamic
changes
ONOO-
during
DILI
vivo.
Therefore,
ONOO--activated
near-infrared
(NIR)
fluorescent
probes
high
sensitivity
and
selectivity
key
early
diagnosis
situ.
Herein,
we
report
novel
ONOO--responsive
NIR
probe,
QCy7-DP,
which
incorporates
donor-dual-acceptor
π-electron
cyanine
skeleton
diphenyl
phosphinate.
The
ONOO--mediated
highly
selective
hydrolytic
cleavage
via
an
addition-elimination
pathway
phosphinate
produced
deprotonated
form
QCy7
physiological
conditions
distinctive
extended
conjugated
system
∼200-fold
enhancement
fluorescence
emission
at
710
nm.
Moreover,
probe
QCy7-DP
was
successfully
used
for
imaging
endogenous
exogenous
concentration
living
cells.
Importantly,
vivo
tests
demonstrated
that
can
effectively
detect
generation
acetaminophen
(APAP)-induced
mouse
model.
This
study
provides
insight
into
design
suitable
spatiotemporal
monitoring
under
different
pathological
conditions.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(4)
Published: March 10, 2024
Abstract
Aggregate‐level
photodynamic
therapy
(PDT)
has
attracted
significant
interest
and
driven
substantial
advances
in
multifunction
phototheranostic
platforms.
As
exemplified
by
two
typical
instances
of
aggregation‐caused
quenching
reactive
oxygen
species
(ROS)
aggregation‐induced
generation
ROS,
the
aggregation
effect
plays
a
role
on
ROS
photosensitizers
(PSs),
which
is
worthy
in‐depth
exploration
full
utilization.
However,
contrast
to
well‐developed
researches
luminescence,
studies
concerning
are
currently
relatively
nascent
disjointed
stage,
lacking
guidance
from
firmly
established
research
paradigm.
To
advance
this
regard,
review
aims
at
providing
consolidated
overview
fundamental
principles
status
effects
generation.
Here,
can
be
organized
into
main
facets.
One
involves
comparison
between
isolated
state
aggregated
state,
mainly
conducted
methods
changing
solvent
environments
adding
adjuvants
given
solvent.
The
other
underscores
distinctions
different
aggregate
states,
consisting
three
parts,
namely
within
same
or
categories
based
classification
single‐component
multicomponent
aggregates.
In
endeavor,
we
will
present
our
views
current
methodologies
that
explore
how
affects
highlight
design
strategies
leverage
optimize
PS
regiments.
We
aspire
propel
advancement
platforms
accelerate
clinical
implementation
precision
medicine,
inspire
more
contributions
aggregate‐level
photophysics
photochemistry,
pushing
science
materials
forward.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 12, 2024
Abstract
The
dense
extracellular
matrix
(ECM)
in
solid
tumors,
contributed
by
cancer‐associated
fibroblasts
(CAFs),
hinders
penetration
of
drugs
and
diminishes
their
therapeutic
outcomes.
A
sequential
treatment
strategy
remodeling
the
ECM
via
a
CAF
modifier
(dasatinib,
DAS)
is
proposed
to
promote
an
immunogenic
cell
death
(ICD)
inducer
(epirubicin,
Epi)
apoptotic
vesicles,
ultimately
enhancing
efficacy
against
breast
cancer.
Dendritic
poly(oligo(ethylene
glycol)
methyl
ether
methacrylate)
(POEGMA)‐based
nanomedicines
(poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS]
(P‐DAS)
poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi]
(P‐Epi))
are
developed
for
delivery
DAS
Epi,
respectively.
P‐DAS
reprograms
CAFs
reduce
collagen
downregulating
anabolism
energy
metabolism,
thereby
reducing
deposition.
regulated
can
enhance
tumor
P‐Epi
strengthen
its
ICD
effect,
leading
amplified
antitumor
immune
response.
In
cancer‐bearing
mice,
this
approach
alleviates
barrier,
resulting
reduced
burden
increased
cytotoxic
T
lymphocyte
infiltration,
more
encouragingly,
synergizes
effectively
with
anti‐programmed
1
(PD‐1)
therapy,
significantly
inhibiting
growth
preventing
lung
metastasis.
Furthermore,
systemic
toxicity
barely
detectable
after
P‐Epi.
This
opens
new
avenue
treating
desmoplastic
tumors
metabolically
targeting
overcome
barrier.
