Chemical and Pharmaceutical Bulletin,
Journal Year:
2024,
Volume and Issue:
72(3), P. 311 - 312
Published: March 15, 2024
An
improvement
of
the
two-photon
excitation
was
achieved
using
8-azacoumarin-type
caged
compounds,
which
showed
large
values
uncaging
action
cross-section
(δu
>0.1
Goeppert–Mayer
(GM)).
In
particular,
7-hydroxy-6-iodo-8-azacoumarin
(8-aza-Ihc)-caged
compound
an
excellent
value
=
1.28
GM).
Therefore,
photolabile
protecting
groups
(PPGs)
can
be
used
as
sources.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(32), P. 17497 - 17514
Published: Aug. 3, 2023
meso-methyl
BODIPY
photocages
have
recently
emerged
as
an
exciting
new
class
of
photoremovable
protecting
groups
(PPGs)
that
release
leaving
upon
absorption
visible
to
near-infrared
light.
In
this
Perspective,
we
summarize
the
development
these
PPGs
and
highlight
their
critical
photochemical
properties
applications.
We
discuss
PPGs,
structure–photoreactivity
studies,
insights
into
photoreaction
mechanism,
scope
functional
can
be
caged,
chemical
synthesis
structures,
how
substituents
alter
water
solubility
PPG
direct
specific
subcellular
compartments.
Applications
exploit
unique
optical
are
also
discussed,
from
wavelength-selective
photoactivation
biological
studies
photoresponsive
organic
materials
photomedicine.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 15, 2024
Abstract
Photoactivatable
molecules,
with
high‐precision
spatialtemporal
control,
have
largely
promoted
bioimaging
and
phototherapy
applications
of
fluorescent
dyes.
Here,
the
first
photoactivatable
sensor
(
BI
)
is
described
that
can
be
triggered
by
broad
excitation
light
(405–660
nm),
which
further
undergoes
intersystem
crossing
H‐atom
transfer
processes
to
forming
superoxide
anion
radicals
(O
2
−•
carbon
radicals.
Particularly,
photoinduced
gain
carbon‐centered
BI•
allows
for
radical‐radical
coupling
afford
combined
crosslink
product
BI─BI
),
would
oxidized
in
presence
O
produce
an
extended
conjugate
system
near
infrared
emission
(820
nm).
Besides,
photochemically
generated
Cy─BI
possesses
ultra‐high
photothermal
conversion
efficiency
up
90.9%,
optimized
potential.
What′s
more,
Western
Blot
assay
reveals
both
photoproduct
efficiently
inhibit
expression
CHK1,
irradiation
induces
apoptosis
ultimately
enhances
phototherapeutic
effects.
Thus,
combination
cell
cycle
block
inducing
apoptosis,
photodynamic
therapy
treatments
significantly
suppress
solid
tumor
vivo
antitumor
efficacy
explorations.
This
a
novel
finding
developing
as
well
applicability
photoimaging
tumor‐related
areas.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(6), P. 2062 - 2073
Published: Jan. 1, 2024
Improving
the
efficiency
of
photocleavable
protecting
groups
is
crucial
for
their
application.
Here
we
reveal
how
fate
contact
ion
pair
intermediate
plays
a
key
role
in
defining
this
efficiency.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(12), P. 8417 - 8424
Published: March 18, 2024
Photocages
enable
scientists
to
take
full
control
over
the
activity
of
molecules
using
light
as
a
biocompatible
stimulus.
Their
emerging
applications
in
photoactivated
therapies
call
for
efficient
uncaging
near-infrared
(NIR)
window,
which
represents
fundamental
challenge.
Here,
we
report
synthetically
accessible
cyanine
photocages
that
liberate
alcohol,
phenol,
amine,
and
thiol
payloads
upon
irradiation
with
NIR
up
820
nm
aqueous
media.
The
display
unique
chameleon-like
behavior
operate
via
two
distinct
mechanisms:
photooxidation
heterolytic
bond
cleavage.
latter
process
constitutes
first
example
direct
scission
by
single
photon
ever
observed
dyes
or
at
wavelengths
exceeding
800
nm.
Modulation
beating
rates
human
cardiomyocytes
achieved
light-actuated
release
adrenergic
agonist
etilefrine
submicromolar
concentrations
low
doses
(∼12
J
cm
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(47)
Published: Oct. 4, 2023
Ultrasound,
featuring
deep
tissue
penetration
and
noninvasiveness,
offers
a
new
opportunity
to
activate
functional
materials
in
tumor-selective
manner.
However,
very
few
direct
ultrasound-responsive
redox
systems
are
applicable
under
therapeutic
ultrasound
(1
MHz).
Herein,
the
investigations
on
nanoprodrug
of
DHE@PEG-SS-DSPE
reported,
which
exhibit
glutathione-activated
release
dihydroethidium
(DHE)
tumor
cells.
DHE
is
stable
with
good
biosafety
transformed
into
cytotoxic
ethidium
induce
DNA
damage
medical
irradiation,
accompanied
by
generation
reactive
oxygen
species.
Further,
could
effectively
ferroptosis
through
glutathione
depletion,
lipid
peroxide
accumulation,
downregulation
peroxidase
4.
In
vivo
studies
confirmed
that
nanoparticles
inhibit
both
growth
solid
tumors
expression
metastasis-related
proteins
mice,
thus
inhibiting
lung
metastasis.
This
DHE-based
prodrug
nanosystem
lay
foundation
for
design
ultrasound-driven
agents.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: April 13, 2024
The
emerging
field
of
photopharmacology
is
a
promising
chemobiological
methodology
for
optical
control
drug
activities
that
could
ultimately
solve
the
off-target
toxicity
outside
disease
location
many
drugs
treatment
given
pathology.
use
photolytic
reactions
looks
very
attractive
light-activated
release
but
requires
to
develop
sensitive
red
or
near-infrared
light
excitation
better
tissue
penetration.
This
review
will
present
concepts
triplet-triplet
annihilation
upconversion-based
photolysis
and
their
recent
in
vivo
applications
light-induced
delivery
using
photoactivatable
nanoparticles.
