Cancers,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2552 - 2552
Published: July 16, 2024
This
review
comprehensively
explores
the
complex
interplay
between
extracellular
vesicles
(ECVs)/exosomes
and
circadian
rhythms,
with
a
focus
on
role
of
this
interaction
in
hepatocellular
carcinoma
(HCC).
Exosomes
are
nanovesicles
derived
from
cells
that
facilitate
intercellular
communication
by
transporting
bioactive
molecules
such
as
proteins,
lipids,
RNA/DNA
species.
ECVs
implicated
range
diseases,
where
they
play
crucial
roles
signaling
their
surrounding
environment.
In
setting
cancer,
known
to
influence
cancer
initiation
progression.
The
scope
extends
all
types,
synthesizing
existing
knowledge
various
ECVs.
A
unique
aspect
is
emphasis
circadian-controlled
release
composition
exosomes,
highlighting
potential
biomarkers
for
early
detection
monitoring
metastasis.
We
also
discuss
how
rhythms
affect
multiple
cancer-related
pathways,
proposing
disruptions
clock
can
alter
tumor
development
treatment
response.
Additionally,
delves
into
components
ECV
biogenesis
impact
reshaping
microenvironment,
key
component
driving
HCC
Finally,
we
address
clinical
applications
ECVs,
particularly
use
diagnostic
tools
drug
delivery
vehicles,
while
considering
challenges
associated
implementation.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2236 - 2252
Published: Jan. 1, 2024
Plant-derived
exosomes
(PDEs)
show
promising
potential
to
be
developed
as
a
therapeutic
agent
against
cancer,
owing
their
multiple
advantages
such
low
toxicity,
biocompatibility,
availability,
affordability,
etc.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(7), P. 2576 - 2590
Published: June 14, 2023
Cancer
is
a
complex
deadly
disease
that
has
caused
global
health
crisis
in
recent
epochs.
Colorectal
cancer
(CRC)
the
third
most
common
malignant
gastrointestinal
disease.
It
led
to
high
mortality
due
early
diagnostic
failure.
Extracellular
vesicles
(EVs)
come
with
promising
solutions
for
CRC.
Exosomes
(a
subpopulation
of
EVs)
play
vital
role
as
signaling
molecules
CRC
tumor
microenvironment.
secreted
from
all
active
cells.
Exosome-based
molecular
transport
(DNA,
RNA,
proteins,
lipids,
etc.)
transforms
recipient
cell's
nature.
In
CRC,
cell-derived
exosomes
(TEXs)
regulate
multiple
events
development
and
progression
such
immunogenic
suppression,
angiogenesis,
epithelial–mesenchymal
transitions
(EMT),
physical
changes
extracellular
matrix
(ECM),
metastasis.
Biofluid-circulated
tumor-derived
are
potential
tool
liquid
biopsy.
colorectal
detection
creates
great
impact
biomarker
research.
The
exosome-associated
theranostics
approach
state-of-the-art
method.
this
review,
we
address
associated
progression,
on
screening
(diagnostic
prognostic
biomarkers),
also
highlight
several
clinical
trials,
well
future
directions
exosome-based
Hopefully,
it
will
encourage
researchers
develop
theranostic
fight
Clinical and Translational Discovery,
Journal Year:
2023,
Volume and Issue:
3(4)
Published: June 29, 2023
Abstract
Exosome
is
nanosized
tiny
membrane‐bound
vesicles
and
a
subpopulation
of
extracellular
(EVs).
In
general,
it
participates
in
intercellular
communication
acts
as
messenger
several
pathological
complications.
cancer
interlink
the
most
exciting
domain
current
research.
The
internal
molecular
cargos
(proteins,
lipids,
metabolites,
miRNA,
DNA)
tumor
derived
exosomes
(TEXs)
are
capable
transforming
normal
cells
into
phenotypes.
DNA
less
explored
area
EVs
It
involved
events
progression
such
uncontrol
cell
growth,
reprogramming
immune
cells,
metastasis,
therapeutic
resistance.
Exo‐DNA
also
epigenetic
alteration,
which
promotes
cancer.
has
great
impact
on
theranostics
(biomarker
therapeutics)
Exo‐DNA‐based
examination
supports
more
detailed
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(8), P. 8489 - 8506
Published: April 15, 2024
Cancer
is
the
most
challenging
health
complication
worldwide.
Scientific
society
has
tried
to
decode
its
complications
and
developing
a
smart
solution
for
mankind.
Extracellular
vesicles
(EVs)
are
an
emerging
frontier
in
cancer
research.
EVs
provide
fresh
insight
into
understanding
of
released
from
all
active
cells.
classified
some
major
classes,
such
as
apoptotic
bodies,
microvesicles,
exosomes.
Exosomes
among
exciting
tools
current
research
they
work
cellular
messengers
(which
reflects
cell's
healthy
or
pathological
conditional
status).
In
tumor
microenvironment,
regulate
several
complicated
events
uncontrolled
cell
growth,
immune
suppression,
angiogenesis,
extracellular
matrix
remodeling,
metastasis,
organ-specific
drug
therapeutic
resistance,
stem
development.
also
source
promising
biomarkers
involved
both
diagnosis
prognosis
performs
role.
Exosomes-based
nanomedicine
which
application
nanosize
theranostics
sensor
orientation,
supports
overcoming
management
limitations,
early
therapeutics
specific,
effective,
affordable.
this
review,
we
have
highlighted
integration
exosomes
nanotechnology
cutting-edge
approach
precision
oncology.
Clinical and Translational Discovery,
Journal Year:
2024,
Volume and Issue:
4(1)
Published: Jan. 28, 2024
Abstract
The
epithelial–mesenchymal
transition
(EMT)
represents
a
pivotal
frontier
in
oncology,
playing
central
role
the
metastatic
cascade
of
cancer—a
leading
global
health
challenge.
This
comprehensive
review
delves
into
complexities
EMT,
process
where
cancer
cells
gain
exceptional
mobility,
facilitating
their
invasion
distant
organs
and
establishment
secondary
malignancies.
We
thoroughly
examine
myriad
factors
influencing
encompassing
transcription
factors,
signalling
pathways,
metabolic
alterations,
microRNAs,
long
non‐coding
RNAs,
epigenetic
changes,
exosomal
interactions
intricate
dynamics
tumour
microenvironment.
Particularly,
emphasises
advanced
stages
crucial
for
development
highly
aggressive
phenotypes.
During
this
phase,
penetrate
vascular
barrier
exploit
bloodstream
to
propagate
life‐threatening
metastases
through
mesenchymal–epithelial
transition.
also
explore
EMT's
significant
fostering
dormancy,
senescence,
emergence
stem
formidable
challenge
therapeutic
resistance.
Our
transcends
mere
inventory
EMT‐inducing
elements;
it
critically
assesses
current
state
EMT‐focused
clinical
trials,
revealing
both
hurdles
breakthroughs.
Highlighting
potential
EMT
research,
we
project
its
transformative
impact
on
future
therapy.
exploration
is
aimed
at
paving
way
towards
an
era
effectively
managing
relentless
disease,
positioning
forefront
innovative
research
strategies.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(4), P. 2128 - 2139
Published: April 3, 2024
Cancer
research
has
made
significant
progress
in
recent
years,
and
extracellular
vesicles
(EVs)
based
cancer
investigation
reveals
several
facts
about
cancer.
Exosomes
are
a
subpopulation
of
EVs.
In
the
present
decade,
exosomes
is
mostly
highlighted
for
theranostic
research.
Tumor
cell
derived
(TEXs)
promote
but
there
multiple
sources
that
can
be
used
as
therapeutic
agents
(plant
exosomes,
stem
cell-derived
modified
or
synthetic
exosomes).
Stem
cells
regenerative
medicine
faces
numerous
challenges,
such
tumor
development,
cellular
reprogramming
etc.,
therefore
addressing
these
complications
becomes
essential.
serves
an
answer
to
problems
offers
better
solution.
Global
indicates
also
play
dual
role
system
by
either
inhibiting
promoting
Modified
which
genetically
engineered
surface
increase
efficacy
properties
considered
target
above
concerns.
However,
difficulties
associated
with
include
variations
heterogenity,
isolation
protocols,
large
scale
production,
have
managed
effectively.
this
review,
we
explore
biogenesis,
exosome
sources,
drug
delivery,
clinical
trial
related
challenges
domain
future
orientation.
This
article
may
encourage
researchers
develop
effective
affordable
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
As
we
progress
into
the
21st
century,
cancer
stands
as
one
of
most
dreaded
diseases.
With
approximately
in
every
four
individuals
facing
a
lifetime
risk
developing
cancer,
remains
serious
health
challenges
worldwide.
Its
multifaceted
nature
makes
it
an
arduous
and
tricky
problem
to
diagnose
treat.
Over
years,
researchers
have
explored
plenty
approaches
avenues
improve
management.
One
notable
strategy
includes
study
extracellular
vesicles
(EVs)
potential
biomarkers
therapeutics.
Among
these
EVs,
exosomes
emerged
particularly
promising
candidates
due
their
unique
characteristic
properties
functions.
They
are
small
membrane-bound
secreted
by
cells
carrying
cargo
biomolecules
such
proteins,
nucleic
acids,
lipids.
These
play
crucial
roles
intercellular
communication,
facilitating
transfer
biological
information
between
cell-to-cell
communication.
Exosomes
transport
cargoes
DNA,
RNA,
lipids
involved
cellular
reprogramming
promoting
cancer.
In
this
review,
explore
molecular
composition
exosomes,
significance
chemistry
development,
its
theranostic
application
well
research
complications
solutions.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
7(1), P. 44 - 58
Published: Dec. 18, 2023
Epithelial-mesenchymal
transition
(EMT)
is
a
fundamental
process
driving
cancer
metastasis,
transforming
non-motile
cells
into
motile
population
that
migrates
to
distant
organs
and
forms
secondary
tumors.
In
recent
years,
research
has
revealed
strong
connection
between
exosomes
the
EMT.
Exosomes,
subpopulation
of
extracellular
vesicles,
facilitate
cellular
communication
dynamically
regulate
various
aspects
including
immune
cell
suppression,
matrix
remodeling,
metastasis
initiation,
EMT
organ-specific
metastasis.
Tumor-derived
(TEXs)
their
molecular
cargo,
comprising
proteins,
lipids,
nucleic
acids,
carbohydrates,
are
essential
components
promote
in
cancer.
TEXs
miRNAs
play
crucial
role
reprogramming
tumor
microenvironment,
while
TEX
surface
integrins
contribute
Exosome-based
offers
deeper
understanding
about
an
effective
theranostic
platform
development.
Additionally,
therapeutic
sources
paving
way
for
innovative
treatment
this
Review,
we
spotlight
impact,
aiming
inspire
researchers
worldwide
explore
fascinating
field
more
ways.
