PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review) DOI Creative Commons
Xinyu Gao,

Cuixue Ma,

Shan Liang

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(3)

Published: July 4, 2024

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that widely reported cancer, infectious diseases neurological disorders. Cardiovascular (CVDs) are important global health problem, posing serious threat to individuals' lives. An increasing body research shows inflammation pivotal role CVDs, which provides theoretical basis for PANoptosis promote the progression CVDs. To date, only sporadic studies on CVDs have its field not fully explored. Elucidating various modes cardiomyocyte specific molecular mechanisms links among death under stressful stimuli is notable clinical significance deeper understanding pathophysiology The present review summarizes pyroptosis, necroptosis their prospects

Language: Английский

Scutellarin inhibits inflammatory PANoptosis by diminishing mitochondrial ROS generation and blocking PANoptosome formation DOI

Tao Yuan,

Haiyan Yang, Yaping Li

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112710 - 112710

Published: July 18, 2024

Language: Английский

Citations

6
Exploration and breakthrough in the mode of chondrocyte death - A potential new mechanism for osteoarthritis DOI Creative Commons
Bo Chen, Ling Wang,

Dongke Xie

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115990 - 115990

Published: Dec. 6, 2023

Osteoarthritis (OA) is a frequent chronic joint disease in orthopedics that effects individuals and society significantly. Obesity, aging, genetic susceptibility, misalignment are all known risk factors for OA, but its pathomechanism still poorly understood. Researches have revealed OA much complex process related to inflammation, metabolic chondrocyte death. It can affect parts of the characterized by causing death extracellular matrix descent. Previously, was thought develop from excessive mechanical loading leading destruction articular cartilage. Since some programmed cell deaths share pattern destruction, it likely also involves Even though apoptosis pyroptosis been investigated clarifing solely conventional pathways insufficient understand pathophysiology osteoarthritis. With more researches, has discovered osteoarthritis other new processes, including PANoptosis, ferroptosis, senescence, strongly associated. Among these, PANoptosis combines key traits pyroptosis, apoptosis, necrotic into highly coordinated dynamically balanced inflammatory mechanism. Furthermore, we think PANopotosis might obstruct necroptosis senescence. Therefore, order offer direction therapeutic treatment, evaluate development research on multiple chondrocytes OA.

Language: Английский

Citations

14
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome DOI
Yaping Li,

Zhi-ya Zhou,

Yan Liang

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(4), P. 597 - 617

Published: Feb. 14, 2024

Language: Английский

Citations

5
LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation DOI Creative Commons
Yuhang Wang,

Joyce Z. Gao,

Taylor Sakaguchi

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(7), P. 565 - 565

Published: March 23, 2024

Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein belonging to the ROCO family. Within domain of LRRK2, point mutation known as LRRK2 G2019S has emerged most prevalent variant associated with Parkinson’s disease. Recent clinical studies have indicated that carriers an elevated risk cancers, including colon cancer. Despite this observation, underlying mechanisms linking cancer remain elusive. In study, employing colitis-associated (CAC) model and knock-in (KI) mouse model, we demonstrate promotes pathogenesis cancer, characterized by increased tumor number size in KI mice. Furthermore, enhances intestinal epithelial cell proliferation inflammation within microenvironment. Mechanistically, mice exhibit heightened susceptibility DSS-induced colitis, inhibition activity ameliorating colitis severity CAC progression. Our investigation also reveals inflammasome activation exacerbates gut epithelium necrosis model. Notably, GSDMD inhibitors attenuate Taken together, our findings offer experimental evidence indicating gain-of-kinase colorectal tumorigenesis, suggesting potential therapeutic target patients exhibiting hyper activity.

Language: Английский

Citations

5
PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review) DOI Creative Commons
Xinyu Gao,

Cuixue Ma,

Shan Liang

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(3)

Published: July 4, 2024

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that widely reported cancer, infectious diseases neurological disorders. Cardiovascular (CVDs) are important global health problem, posing serious threat to individuals' lives. An increasing body research shows inflammation pivotal role CVDs, which provides theoretical basis for PANoptosis promote the progression CVDs. To date, only sporadic studies on CVDs have its field not fully explored. Elucidating various modes cardiomyocyte specific molecular mechanisms links among death under stressful stimuli is notable clinical significance deeper understanding pathophysiology The present review summarizes pyroptosis, necroptosis their prospects

Language: Английский

Citations

5