Zooming in and Out of Programmed Cell Death in Osteoarthritis: A Scientometric and Visualized Analysis

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 2479 - 2498

Published: April 1, 2024

During the past decade, mounting evidence has increasingly linked programmed cell death (PCD) to progression and development of osteoarthritis (OA).There is a significant need for thorough scientometric analysis that recapitulates relationship between PCD OA.This study aimed collect articles reviews focusing on in OA, extracting data from January 1st, 2013, October 31st, 2023, using Web Science.Various tools, including VOSviewer, CiteSpace, Pajek, Scimago Graphica, R package, were employed visualization analyses.Notably, China, USA, South Korea emerged as major contributors, collectively responsible more than 85% published papers significantly influencing research this field.Among different institutions, Shanghai Jiao Tong University, Xi'an Zhejiang University exhibited highest productivity.Prolific authors included Wang Wei, Jing, Zhang Li

Language: Английский

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Quercetin Modulates Ferroptosis via the SIRT1/Nrf−2/HO−1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7461 - 7461

Published: July 7, 2024

Osteoarthritis (OA) is the most common joint disease, causing symptoms such as pain, swelling, and deformity, which severely affect patients' quality of life. Despite advances in medical treatment, OA management remains challenging, necessitating development safe effective drugs. Quercetin (QUE), a natural flavonoid widely found fruits vegetables, shows promise due to its broad range pharmacological effects, particularly various degenerative diseases. However, role preventing progression underlying mechanisms remain unclear. In this study, we demonstrated that QUE has protective effect against both vivo vitro, elucidated molecular mechanisms. inhibited expression IL-1β-induced chondrocyte matrix metalloproteinases (MMP3 MMP13) inflammatory mediators INOS COX-2. It also promoted collagen II, thereby extracellular (ECM). Mechanistically, exerts on chondrocytes by activating SIRT1/Nrf-2/HO-1 inhibiting ferroptosis. Similarly, an rat model induced anterior cruciate ligament transection (ACLT), treatment improved articular cartilage damage, reduced normalized abnormal subchondral bone remodeling. serum IL-1β, TNF-α, MMP3, CTX-II, COMP, slowing OA. chondroprotective effects oxidative damage ferroptosis through pathway, effectively alleviating rats.

Language: Английский

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Inflammatory burden index: associations between osteoarthritis and all-cause mortality among individuals with osteoarthritis

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 13, 2024

The newly described inflammatory burden index (IBI) reflects a patient's burden. This study aimed to estimate the association between IBI, osteoarthritis (OA), and all-cause mortality in patients with OA. We extracted data of adults from National Health Nutrition Examination Survey database 1999 2018. After using appropriate survey weights correct for sample bias, we conducted multivariate logistic regression analyses explore IBI OA across three models: unadjusted model, partially adjusted model (adjusting age, sex, race, education level, marital status, PIR, BMI, smoking drinking stroke, CVD, DM, hypertension) fully (which included additional variables: HBA1C, ALT, AST, BUN, TC, HDL). And odds ratios (OR) 95% confidence intervals (CI) were calculated. Similarly, comparable covariates adjustments, employed Cox proportional hazards analysis investigate other 3 models. models fitted calculate hazard (HR) CI mortality. A restricted cubic spline (RCS) was used nonlinear relationships effects. Subgroup performed validate reliability their In total, 22,343 eligible participants included. Multiple revealed that highest had 2.54 times (95%CI, 2.23, 2.90)) higher risk than those lowest Model 1, whereas OR 1.21 1.03, 1.42) 2 1.23 (95%CI,1.05, 1.45) 3. showed 186% 1.50, 2.31) developing death 1. trend remained stable Models (HR,1.54; 95%CI,1.22, 1.95) (HR, 1.41; 95%CI, 1.10, 1.80). RCS significant positive risk. With respect mortality, slight decrease observed quartile second increased increasing IBI. cardiovascular disease, hypertension pivotal after stratification by factors such as marital, smoking, hypertension, most serological indices. provides evidence OA, may be promising signature assessing which, turn, is conducive precise references high-risk population recognition, anti-inflammatory guidance, reducing intervention.

Language: Английский

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Protective effect of clusterin against interleukin‐1β‐induced apoptosis and inflammation in human knee osteoarthritis chondrocytes

Clinical and Translational Science, Journal Year: 2024, Volume and Issue: 17(7)

Published: July 1, 2024

Chondrocyte apoptosis is recognized as one of the pathological features involved in cartilage degeneration driving onset and progression knee osteoarthritis (OA). This study aimed to determine molecular mechanism underlying effect clusterin (CLU), anti-apoptotic molecule, human OA chondrocytes. Primary chondrocytes were isolated from patients divided into five groups: (1) cells treated with interleukin (IL)-1β, (2) CLU alone, (3) a combination IL-1β CLU, (4) LY294002 (PI3K inhibitor) along (5) untreated cells. Production apoptotic, inflammatory, anabolic, catabolic mediators was determined after treatment for 24 h. Our vitro uncovered that significantly suppressed production inflammatory [nitric oxide (NO), IL6, tumor necrosis factor (TNF)-α] apoptotic molecule (caspase-3, CASP3). upregulated messenger ribonucleic acid (mRNA) expressions anabolic factors [SRY-box transcription factor-9 (SOX9) aggrecan (ACAN)], but downregulated mRNA nuclear kappa-B (NF-κB), CASP3, matrix metalloproteinase-13 (MMP13). Anti-apoptotic anti-inflammatory effects mediated through activating PI3K/Akt signaling pathway. The findings suggest might have beneficial on by exerting functions via pathway, making promising target potential therapeutic interventions OA.

Language: Английский

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Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species–mediated activation of the NLRP3 inflammasome

Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: March 4, 2025

This study investigated the role of magnoflorine (MAG) on cartilage protection in osteoarthritis. In vitro studies showed that MAG decreased expression inflammatory factors and inhibited extracellular matrix degradation lipopolysaccharide- ATP-stimulated C28/I2 cells. Importantly, reduced levels pyroptosis-related proteins, including NLRP3, ASC, cleaved-caspase 1, GSDMD-N, IL-18, IL-1β. Mechanistically, mtROS production activation NF-κB signaling pathway. vivo demonstrated sodium iodoacetate-induced factor release were reversed by MAG. Overall, could inhibit mtROS-mediated NLRP3 inflammasome suppressing mitochondrial dysfunction to ameliorate

Language: Английский

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Unravelling changes in single-cell osteoarthritic chondrocytes through coupling of Raman spectroscopy and multivariate curve resolution-alternating least square (MCR-ALS) algorithm

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113264 - 113264

Published: March 1, 2025

Language: Английский

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Sodium alginate microspheres loaded with Quercetin/Mg nanoparticles as novel drug delivery systems for osteoarthritis therapy

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 20, 2025

Osteoarthritis (OA) is the most prevalent arthritic disease characterized by cartilage degradation and low-grade inflammation, for which there remains a lack of efficacious therapeutic interventions. Notably, mitigating impact oxidative stress (OS) inflammatory factors could help alleviate or hinder advancement OA. Given benefits both quercetin (Que) Magnesium ion (Mg2+) in OA treatment, coupled with structural properties Que, we have innovatively developed Que-Mg2+ nanoparticles (NPs), aiming to deliver Que Mg2+ simultaneously achieve enhanced outcomes Moreover, avoid adverse reactions linked frequent injections, sodium alginate (SA) microspheres encapsulating NPs (Que-Mg@SA) were designed treat H2O2-induced cell model. Que-Mg@SA synthesized using ionotropic gelation technique, calcium chloride acting as cross-linking agent. Comprehensive characterization was conducted through transmission electron microscope (TEM), dynamic light scattering (DLS), optical microscope, scanning (SEM), provided detailed insights into their size, zeta potential, morphology, micromorphology. Additionally, microsphere swelling rate release evaluated. The biocompatibility microspheres, along on chondrocyte viability, detected CCK-8 assay live/dead staining. Furthermore, antioxidant anti-inflammatory evaluated examining ROS scavenging ability pro-inflammatory levels, respectively. Finally, regulatory influence extracellular matrix (ECM) metabolism assessed immunofluorescence staining Western blot. Characterization results revealed that Que-Mg exhibit nanoscale diameter, exceptional stability, good dispersibility, while possesses high entrapment efficiency (EE%) loading (LE%), pronounced hygroscopic properties, sustained drug-release capabilities. vitro cellular assays biocompatible significantly restored scavenged excessive ROS, reduced levels cytokines, upregulated anabolic gene expression, downregulated catabolic protease maintained metabolic balance tissue. functionalized our study hold great promise drug delivery system potentially other biomedical applications. Not applicable.

Language: Английский

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Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy

Frontiers in Surgery, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

This study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative comprehensive overview current research status emerging trends in this field. Relevant publications were retrieved from Web Science Core Collection database search query TS = ("chondrocyte* hypertroph*" OR "hypertrophic chondrocyte*" "cartilage hypertroph*") AND ("osteoarthriti*" "OA" "degenerative arthritis"). Several tools, including Vosviewer, CiteSpace, R package (bibliometrix), Excel 2021, utilized on OA. A total 639 publications, published between 1995 2025, identified. The findings indicate a steady global increase hypertrophy, with increasing number studies being high-impact journals, suggesting promising developmental trajectory. China United States are leading OSTEOARTHRITIS CARTILAGE is identified as core journal area, while ANNALS OF THE RHEUMATIC DISEASES has highest impact factor among top publishing journals. Keyword analysis reveals that hotspots primarily focus stem cells, tissue engineering, cartilage repair, inflammation, oxidative stress, autophagy, apoptosis, senescence, related bioactive factors. elucidates at crucial references for future research. Future should continue these potential therapeutic approaches, key phenotypes, regulatory mechanisms, enhance international cooperation develop more effective strategies treatments

Language: Английский

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Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131259 - 131259

Published: April 3, 2024

Language: Английский

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Critical signaling molecules in the temporomandibular joint osteoarthritis under different magnitudes of mechanical stimulation

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 11, 2024

The mechanical stress environment in the temporomandibular joint (TMJ) is constantly changing due to daily mandibular movements. Therefore, TMJ tissues, such as condylar cartilage, synovial membrane and discs, are influenced by different magnitudes of stimulation. Moderate stimulation beneficial for maintaining homeostasis, whereas abnormal leads degeneration ultimately contributes development osteoarthritis (TMJOA), which involves changes critical signaling molecules. Under stimulation, compensatory molecules may prevent degenerative while decompensatory aggravate. In this review, we summarize that stimulated moderate or loading mainly cartilage. Furthermore, classify stimulation-induced into Our aim understand pathophysiological mechanism dysfunction more deeply ever-changing environment, then provide new ideas discovering effective diagnostic therapeutic targets TMJOA.

Language: Английский

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