Functionalization of 2-Mercapto-5-methyl-1,3,4-thiadiazole: 2-(ω-Haloalkylthio) Thiadiazoles vs. Symmetrical Bis-Thiadiazoles DOI Creative Commons

Zhanina S. Petkova,

Rusi Rusew, Boris Shivachev

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1938 - 1938

Published: April 24, 2024

A study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths. The experimental conditions were optimised for each class compounds by altering base used reagents’ proportions, leading to development separate protocols tailored their specific reactivity purification needs. target halogenide reagents bis-thiadiazole ligands obtained either as single products or mixtures easily separable chromatography. Characterisation was performed using 1D 2D NMR spectra in solution, complemented crystal X-ray diffraction (XRD) selected samples, elucidate structural properties.

Language: Английский

Recent advances on cross-coupling of alcohols via borrowing hydrogen catalysis DOI

Suteerna Mullick,

Adrija Ghosh, Debasis Banerjee

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(30), P. 4002 - 4014

Published: Jan. 1, 2024

This article highlights the recent advances and significance of β-alkylation reactions towards synthesis higher order alcohols.

Language: Английский

Citations

14
Ruthenium-catalyzed β-alkylation of secondary alcohols with primary alcohols: Protic N-heterocyclic carbene's promotional influence DOI
Jing Shi,

Lizhu Zhang,

Panpan Li

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1305, P. 137815 - 137815

Published: Feb. 17, 2024

Language: Английский

Citations

3
Diastereoselective Synthesis of Sulfoxide‐Functionalized N‐Heterocyclic Carbene Ruthenium Complexes: An Experimental and Computational Study DOI Creative Commons

Victoria Mechrouk,

Baptiste Leforestier,

Weighang Chen

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(46)

Published: June 12, 2024

The synthesis of sulfoxide-functionalized NHC ligand precursors were carried out by direct and mild oxidation from corresponding thioether with high selectivity. Using these salts, a series cationic [Ru(II)(η

Language: Английский

Citations

1
N‐Heterocyclic Carbene Complexes RuII(Arene) and their Application as ROMP Catalysts, Antioxidant and Anticancer Agents DOI
Rubina Troiano, Domenico Iacopetta, Assunta D’Amato

et al.

European Journal of Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 27(34)

Published: Aug. 16, 2024

Abstract N‐Heterocyclic carbenes (NHCs) play an important role in metal complex catalysis and stabilisation, providing stability under non‐inert conditions a high σ‐donor capacity. They are crucial ligands for the synthesis of organometallic compounds like Ru II ‐complexes, which can operate as very active catalysts variety chemical transformations functionalizations. RA(Ruthenium‐arene)NHC complexes, known their piano‐stool structure, stabilise Ru(II) oxidation state by occupying three ruthenium coordination sites with η 6 ‐coordinated arene ligand. The development dual‐acting ‐arene complexes has sparked increased interest catalytic biological properties. Because broad spectrum, give distinct mechanisms pharmacological action from organic drugs. This study aimed to explore impact ligand amphiphilicity counterion on bioactivity, designing family NHC bearing ester moiety switching wingtip substituent methyl benzyl units. All synthesized were tested norbornene ROMP, benchmark reaction potential anticancer antioxidant compounds.

Language: Английский

Citations

1
Synthesis and reactivity of isomeric Ru complexes with hydroxypyridyl fragment: active catalysts for β‑alkylation of secondary alcohols with primary alcohols DOI
Jing Shi, Panpan Li, Chunjian Qi

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 140159 - 140159

Published: Sept. 23, 2024

Language: Английский

Citations

1
Recent Progress in Developing Thioether-Containing Ligands for Catalysis Applications DOI
Stéphane Bellemin‐Laponnaz, Thierry Achard

Synthesis, Journal Year: 2023, Volume and Issue: 56(09), P. 1369 - 1380

Published: Oct. 17, 2023

Abstract The ligand that stabilizes the metal center is crucial to its catalytic activity. Historically dominated by phosphorus and nitrogen, sulfur has long been little considered as a hetero element for stabilizing potentially active center. However, this situation changing we are seeing more examples incorporate element. This review provides an overview of recent transition-metal-catalyzed reactions with ligands containing neutral groups, i.e. thioethers. A selection published since 2013 illustrates diversity applications thioether-containing shows should be widely used in development homogeneous catalysis. 1 Introduction 2 Phosphorus-Thioether Ligands 3 Nitrogen-Thioether 4 Oxygen-Thioether 5 NHC-Thioether 6 Cycloolefin-Thioether 7 Conclusion

Language: Английский

Citations

2
Synthesis and Crystal Structure of a Chelating N-Heterocyclic Carbene Palladium Complex Containing N-(3-Bromopropyl)-N’-thioether di-functionalized Imidazol-2-ylidene DOI
Yongmei Xiao, Yaowen Liu, Liangru Yang

et al.

Journal of Chemical Crystallography, Journal Year: 2024, Volume and Issue: 54(3), P. 197 - 202

Published: April 8, 2024

Language: Английский

Citations

0
Functionalization of 2-Mercapto-5-methyl-1,3,4-thiadiazole: 2-(ω-Haloalkylthio) Thiadiazoles vs. Symmetrical Bis-Thiadiazoles DOI Creative Commons

Zhanina S. Petkova,

Rusi Rusew, Boris Shivachev

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1938 - 1938

Published: April 24, 2024

A study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths. The experimental conditions were optimised for each class compounds by altering base used reagents’ proportions, leading to development separate protocols tailored their specific reactivity purification needs. target halogenide reagents bis-thiadiazole ligands obtained either as single products or mixtures easily separable chromatography. Characterisation was performed using 1D 2D NMR spectra in solution, complemented crystal X-ray diffraction (XRD) selected samples, elucidate structural properties.

Language: Английский

Citations

0