Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis DOI Creative Commons
Weidong Zhang, Yong Zhao, Fuli Li

et al.

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Jan. 30, 2018

Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, prophylactic drugs. However, they have also been found to adversely affect organisms; previously we that ZnO NPs disrupt pubertal ovarian development, inhibit embryonic development by upsetting -H2AX NF-B pathways, even disturb skin stem cells. Non-targeted metabolomic analysis of biological organisms has suggested an unbiased tool the investigation perturbations response underlying mechanisms. Although metabolomics nanotoxicological studies, very few reports it investigate effects exposure. In current investigation, through a metabolomics-based approach, discovered caused changes plasma metabolites involved anti-oxidative mechanisms, energy metabolism, lipid metabolism hen livers. These results line with earlier findings perturb TCA cycle turn result use alternative sources. We disturbed liver consequently impacted blood balance. Changes metabolomes were correlated hepatic steatosis. Therefore, might be potential biomarkers evaluate metabolic toxicity NP

Language: Английский

Sex and gender analysis improves science and engineering DOI Open Access
Cara Tannenbaum, Robert P. Ellis, Friederike Eyssel

et al.

Nature, Journal Year: 2019, Volume and Issue: 575(7781), P. 137 - 146

Published: Nov. 6, 2019

Language: Английский

Citations

472
Microbial Biodiversity and Bioremediation Assessment Through Omics Approaches DOI Creative Commons

Hema Chandran,

Mukesh Meena, Kanika Sharma

et al.

Frontiers in Environmental Chemistry, Journal Year: 2020, Volume and Issue: 1

Published: Sept. 25, 2020

Industrialization, population burst, and changing lifestyles have resulted in the genesis of non-degradable pollutants languishing environment human health. Biological approaches using microorganisms are gaining importance as an eco-friendly cost-effective substitute to mitigate pollution load. Microorganisms can survive a divergent produce metabolites that degrade transform making it possible revive contaminated sites naturally. Modern omics technologies like metagenomics, transcriptomics, proteomics, etc. been used nowadays design strategies study ecology diversity their application environmental monitoring bioremediation. The present article will focus on techniques reportedly tackle

Language: Английский

Citations

147
Pesticide pestilence: Global scenario and recent advances in detection and degradation methods DOI
Aman Raj, Anamika Dubey, Muneer Ahmad Malla

et al.

Journal of Environmental Management, Journal Year: 2023, Volume and Issue: 338, P. 117680 - 117680

Published: April 1, 2023

Language: Английский

Citations

44
Soil metabolomics - current challenges and future perspectives DOI Creative Commons
Robert W. Brown, Michaela Reay, Florian Centler

et al.

Soil Biology and Biochemistry, Journal Year: 2024, Volume and Issue: 193, P. 109382 - 109382

Published: March 12, 2024

Soil is an extremely complex and dynamic matrix, in part, due to the wide diversity of organisms living within it. organic matter (SOM) fundamental substrate on which delivery ecosystem services depends, providing metabolic fuel drive soil function. As such, studying metabolome (the concentration low molecular weight metabolites), as a subset SOM, holds potential greatly expand our understanding behaviour, fate, interaction functional significance small molecules soil. Encompassing range chemical classes (including amino acids, peptides, lipids carbohydrates) large number individual (ca. n = 105 106), resultant (indirect) output several layers biological hierarchy, namely metagenome, metatranscriptome metaproteome. it may also provide support validation for these "multi-omics" datasets. We present case increased use untargeted metabolomics biochemistry, particularly furthering functions driving SOM composition biogeochemical cycling. Further, we discuss scale challenge terms metabolite extraction, analysis interpretation plant-soil-microbial systems. Lastly, highlight key knowledge gaps currently limit metabolomic approaches better understand processes, including: (i) datasets; (ii) source, emission fate soil-derived volatile compounds (VOCs), (iii) assessing temporal fluxes metabolites, (iv) monitoring ecological interactions rhizosphere. While application science still its relative infancy, importance biochemical system relation regulation, management underpinning further elucidating links between organisms, well ability community process cycle nutrients.

Language: Английский

Citations

20
A Bigger Toolbox: Biotechnology in Biodiversity Conservation DOI
Richard T. Corlett

Trends in biotechnology, Journal Year: 2016, Volume and Issue: 35(1), P. 55 - 65

Published: July 14, 2016

Language: Английский

Citations

122
Ecotoxicoproteomics: A decade of progress in our understanding of anthropogenic impact on the environment DOI Creative Commons
Duarte Gouveia, Christine Almunia,

Yannick Cogne

et al.

Journal of Proteomics, Journal Year: 2018, Volume and Issue: 198, P. 66 - 77

Published: Dec. 6, 2018

Anthropogenic pollutants are found worldwide. Their fate and effects on human ecosystem health must be appropriately monitored. Today, ecotoxicology is focused the development of new methods to assess impact pollutant toxicity living organisms ecosystems. In situ biomonitoring often uses sentinel animals for which, ideally, molecular biomarkers have been defined thanks which environmental quality can assessed. this context, high-throughput proteomics offer an attractive approach study early responses stressors. This used identify pathways, quantify more precisely novel biomarkers, draw possible adverse outcome pathways. review, we discuss major advances in ecotoxicoproteomics made over last decade present current state knowledge, emphasizing technological conceptual advancements that allowed breakthroughs field, aims "make our planet great again". Ecotoxicoproteomics a protein-centric methodology useful could future applications as part chemical risk assessment monitoring. Ecotoxicology employing non-model with highly divergent phylogenetic backgrounds preserve functioning ecosystems overall range biological species supporting them. The classical workflow involves protein identification, functional annotation, extrapolation across species. Thus, it essential develop multi-omics approaches order unravel information construct most suitable databases identification pathway analysis Current instrumentation available software allow relevant combined transcriptomic/proteomic studies performed almost any review summarizes these illustrates how they implemented routine biomonitoring.

Language: Английский

Citations

82
Integrated assessment of toxic effects of maghemite (γ-Fe2O3) nanoparticles in zebrafish DOI
Rolando André Rios Villacis,

José Sousa Filho,

Benjamı́n Piña

et al.

Aquatic Toxicology, Journal Year: 2017, Volume and Issue: 191, P. 219 - 225

Published: Aug. 8, 2017

Language: Английский

Citations

62
Immunological Responses of Marine Bivalves to Contaminant Exposure: Contribution of the -Omics Approach DOI Creative Commons
Teresa Balbi, Manon Auguste, Caterina Ciacci

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 18, 2021

The increasing number of data studies on the biological impact anthropogenic chemicals in marine environment, together with great development invertebrate immunology, has identified bivalves as a key group for immunological responses to pollutant exposure. Available effects contaminants bivalve immunity, evaluated different functional and molecular endpoints, underline that individual parameters (cellular or humoral) expression selected immune-related genes can distinctly react depending conditions Therefore, measurement suite immune biomarkers hemocytes hemolymph is needed correct evaluation overall contaminant exposure organism's immunocompetence. Recent advances -omics technologies are revealing complexity players response species. Although represent extremely powerful tools understanding pollutants physiological function such defense, approach only been utilized this area investigation last few years. In work, available information obtained from application evaluate immunity summarized. shows knowledge subject still quite limited understand environmental relevance any change homeostasis induced by contaminants, combination both assays cutting-edge technology (transcriptomics, proteomics, metabolomics) required. addition, utilization metagenomics may explain how complex interplay between system its associated bacterial communities be modulated pollutants, turn affect homeostatic processes host, host-pathogen interactions, increased susceptibility disease. Integrating approaches will contribute mechanism responsible dysfunction ecologically economically relevant species further their sensitivity multiple stressors, thus resulting health

Language: Английский

Citations

56
Emerging contaminants and biological effects in Arctic wildlife DOI
Christian Sonne, Runé Dietz, Bjørn Munro Jenssen

et al.

Trends in Ecology & Evolution, Journal Year: 2021, Volume and Issue: 36(5), P. 421 - 429

Published: Feb. 16, 2021

Language: Английский

Citations

39
Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent DOI Creative Commons
Gustaf Ekelund Ugge, Annie Jonsson, Olof Berglund

et al.

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 29(2), P. 2158 - 2170

Published: Aug. 7, 2021

Abstract Using a selection of molecular biomarkers, we evaluated responses in freshwater mussels ( Anodonta anatina ) exposed to effluent from an industrial wastewater treatment facility. The aims this work were (1) assess biomarkers general toxicity under sublethal exposure anthropogenic mixture chemicals, represented by arbitrary effluent, and (2) evaluate the potential A. as bioindicator pollution. Adult n = total 32; 24 males 8 females) (96 h) laboratory fixed dilution or control standardized freshwater. Metal concentrations higher order magnitude more, compared control. Toxic unit estimates used proxies chemical stress, Cu, Ni, Zn identified major contributors (Cu> Ni > Zn). Six transcriptional cat , gst hsp70 hsp90 mt sod two biochemical (AChE, GST) analyzed tissues, gills, digestive glands. Out 16 (eight × tissues), 14 effect sizes small (within ± 28 % control) differences non-significant p 0.05). Results did however show that AChE activity increased 40% gills control, expression was 100% female (3) three marker signals (AChE both gills) differed between sexes, independent treatment. highlight need for further investigation biomarker variability robustness .

Language: Английский

Citations

34