BMEMat,
Journal Year:
2023,
Volume and Issue:
1(4)
Published: Sept. 2, 2023
Abstract
Bone
defects
are
encountered
substantially
in
clinical
practice,
and
bionic
scaffolds
represent
a
promising
solution
for
repairing
bone
defects.
However,
it
is
difficult
to
fabricate
with
structures
reconstruct
the
microenvironment
fulfill
satisfying
repair
effects.
In
this
review
article,
we
first
discuss
various
strategies
design
construction
of
promote
defect
repair,
especially
including
structural
scaffold
integration
bioactive
substances
together
application
external
stimuli.
We
then
roles
artificial
intelligence
medical
imaging
aiding
treatment.
Finally,
point
out
challenges
future
outlooks
developing
multifunctional
scaffolds,
aiming
provide
insights
improving
regeneration
efficacy
accelerating
translation.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: March 18, 2022
With
the
gradual
demographic
shift
toward
an
aging
and
obese
society,
increasing
number
of
patients
are
suffering
from
bone
cartilage
injuries.
However,
conventional
therapies
hindered
by
defects
materials,
failing
to
adequately
stimulate
necessary
cellular
response
promote
sufficient
regeneration,
remodeling
osseointegration.
In
recent
years,
rapid
development
nanomedicine
has
initiated
a
revolution
in
orthopedics,
especially
tissue
engineering
regenerative
medicine,
due
their
capacity
effectively
responses
on
nanoscale
with
enhanced
drug
loading
efficiency,
targeted
capability,
increased
mechanical
properties
improved
uptake
rate,
resulting
therapeutic
effect.
Therefore,
comprehensive
review
advancements
for
diseases
is
timely
beneficial.
This
firstly
summarized
wide
range
existing
nanotechnology
applications
medical
field.
The
progressive
nano
delivery
systems
nanomedicine,
including
nanoparticles
biomimetic
techniques,
which
lacking
current
literature,
further
described.
More
importantly,
we
also
highlighted
research
repair
using
latest
preclinical
clinical
examples,
discussed
directions
nano-therapies
future
practice.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(4)
Published: July 12, 2023
Repairing
articular
osteochondral
defects
present
considerable
challenges
in
self-repair
due
to
the
complex
tissue
structure
and
low
proliferation
of
chondrocytes.
Conventional
clinical
therapies
have
not
shown
significant
efficacy,
including
microfracture,
autologous/allograft
transplantation,
cell-based
techniques.
Therefore,
engineering
has
been
widely
explored
repairing
by
leveraging
natural
regenerative
potential
biomaterials
control
cell
functions.
However,
is
a
gradient
with
smooth
transition
from
cartilage
subchondral
bone,
involving
changes
chondrocyte
morphologies
phenotypes,
extracellular
matrix
components,
collagen
type
orientation,
cytokines.
Bioinspired
scaffolds
developed
simulating
characteristics
heterogeneous
tissues,
such
as
pores,
osteochondrogenesis-inducing
factors,
satisfy
anisotropic
features
matrices.
repair
altering
microenvironments
growth
induce
osteochondrogenesis
promote
formation
interfaces
compared
homogeneous
scaffolds.
This
review
outlines
meaningful
strategies
for
based
on
predicts
pros
cons
prospective
translation
into
practice.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(7), P. 6466 - 6479
Published: March 30, 2023
Bone
fractures
are
often
companied
with
poor
bone
healing
and
high
rates
of
infection.
Early
recruitment
mesenchymal
stem
cells
(MSCs)
is
critical
for
initiating
efficient
repair,
mild
thermal
stimulation
can
accelerate
the
recovery
chronic
diseases.
Here,
a
bioinspired,
staged
photothermal
effect-reinforced
multifunctional
scaffold
was
fabricated
repair.
Uniaxially
aligned
electrospun
polycaprolactone
nanofibers
were
doped
black
phosphorus
nanosheets
(BP
NSs)
to
endow
excellent
near-infrared
(NIR)
responsive
capability.
Apt19S
then
decorated
on
surface
selectively
recruit
MSCs
toward
injured
site.
Afterward,
microparticles
phase
change
materials
loaded
antibacterial
drugs
also
deposited
scaffold,
which
could
undergo
solid-to-liquid
transition
above
39
°C,
triggering
release
payload
eliminate
bacteria
prevent
Under
NIR
irradiation,
photothermal-mediated
up-regulation
heat
shock
proteins
accelerated
biodegradation
BP
NSs
promote
osteogenic
differentiation
biomineralization.
Overall,
this
strategy
shows
ability
elimination,
recruitment,
regeneration
promotion
assistance
effect
in
vitro
vivo,
emphasizes
design
bioinspired
its
potential
tissue
engineering.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
16, P. 472 - 484
Published: Feb. 20, 2022
Lipid-based
boundary
layers
formed
on
liposome-containing
hydrogels
can
facilitate
lubrication.
However,
these
be
damaged
by
shear,
resulting
in
decreased
Here,
a
shear-responsive
boundary-lubricated
drug-loaded
hydrogel
is
created
incorporating
celecoxib
(CLX)-loaded
liposomes
within
dynamic
covalent
bond-based
hyaluronic
acid
(HA)
(CLX@Lipo@HA-gel).
The
cross-linked
network
enables
the
to
get
restructured
response
and
HA
matrix
allows
accumulation
of
internal
liposome
microreservoirs
sliding
surfaces,
which
results
formation
provide
stable
Moreover,
hydration
shells
surrounding
retard
degradation
process,
thus
helping
sustaining
Furthermore,
vitro
vivo
experiments
found
that
CLX@Lipo@HA-gels
maintain
anabolic-catabolic
balance,
alleviate
cartilage
wear,
attenuate
osteoarthritis
progression
delivering
CLX
Overall,
serve
as
lubricants
drug-delivery
vehicles
friction-related
diseases
like
osteoarthritis.
Small,
Journal Year:
2022,
Volume and Issue:
18(36)
Published: April 27, 2022
Abstract
Owing
to
the
development
of
nanotechnology
and
noninvasive
treatment,
thermal
therapy
in
combination
with
external
stimuli
has
been
applied
for
tissue
engineering
regenerative
medicine
(TERM),
which
attracted
more
attention
recent
years.
In
this
review,
progress
applying
a
variety
non‐invasive
therapeutic
modalities
TERM,
including
photothermal
therapy,
magnetic
thermotherapy,
ultrasound
as
well
other
therapeutics
are
discussed.
The
parameters
conditions
that
need
be
considered
regulated
realize
well‐controlled
regeneration
also
Afterwards,
current
concerns
challenges
putting
into
clinical
applications
pointed
out.
At
last,
perspectives
provided
future
directions,
aiming
providing
opportunities
novel
pathway
TERM.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Currently,
the
clinical
treatment
of
critical
bone
defects
attributed
to
various
causes
remains
a
great
challenge,
and
repairing
these
with
synthetic
substitutes
is
most
common
strategy.
In
general,
tissue
engineering
materials
that
mimic
structural,
mechanical
biological
properties
natural
have
been
extensively
applied
fill
promote
in
situ
regeneration.
Hydrogels
extracellular
matrix
(ECM)-like
are
materials,
among
which
methacrylate-based
gelatin
(GelMA)
hydrogels
widely
used
because
their
tunable
properties,
excellent
photocrosslinking
capability
good
biocompatibility.
Owing
lack
osteogenic
activity,
however,
GelMA
combined
other
types
activities
improve
current
composites.
There
three
main
aspects
consider
when
enhancing
regenerative
performance
composite
materials:
osteoconductivity,
vascularization
osteoinduction.
Bioceramics,
bioglass,
biomimetic
scaffolds,
inorganic
ions,
bionic
periosteum,
growth
factors
two-dimensional
(2D)
nanomaterials
combinations
achieve
enhanced
regeneration
activities.
Three-dimensional
(3D)-bioprinted
scaffolds
popular
research
topic
(BTE),
printed
customized
suitable
for
restoring
large
irregular
due
shape
structural
tunability,
Herein,
recent
progress
on
GelMA-based
hydrogel
as
multifunctional
platforms
plastic
or
orthopedic
clinics
systematically
reviewed
summarized.
These
strategies
pave
way
design
effective
reconstruction
biosafety.
This
review
provides
novel
insights
into
development
trends
(BTE)
correcting
defects,
contents
summarized
emphasized
from
perspectives
(osteoconductivity,
vascularization,
osteoinduction
3D-bioprinting).
addition,
advantages
deficiencies
put
forward,
corresponding
improvement
measures
presented
prior
application
near
future
(created
BioRender.com).
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(11), P. 4879 - 4903
Published: Jan. 1, 2022
In
recent
decades,
extracellular
vesicles
(EVs),
as
bioactive
cell-secreted
nanoparticles
which
are
involved
in
various
physiological
and
pathological
processes
including
cell
proliferation,
immune
regulation,
angiogenesis
tissue
repair,
have
emerged
one
of
the
most
attractive
nanotherapeutics
for
regenerative
medicine.
Herein
we
provide
a
systematic
review
latest
progress
EVs
applications.
Firstly,
will
briefly
introduce
biogenesis,
function
isolation
technology
EVs.
Then,
underlying
therapeutic
mechanisms
native
unmodified
engineering
strategies
modified
entities
be
discussed.
Subsequently,
main
focus
placed
on
repair
regeneration
applications
organs
brain,
heart,
bone
cartilage,
liver
kidney,
well
skin.
More
importantly,
current
clinical
trials
medicine
also
highlighted.
Finally,
future
challenges
insightful
perspectives
currently
developed
EV-based
biomedicine
short,
opened
new
horizons
biologists,
chemists,
nanoscientists,
pharmacists,
clinicians,
making
possible
powerful
tools
therapies
